Literature DB >> 34672693

Impact of neurodegenerative diseases on human adult hippocampal neurogenesis.

J Terreros-Roncal1,2,3, E P Moreno-Jiménez1,2,3, M Flor-García1,2,3, C B Rodríguez-Moreno1,3, M F Trinchero4, F Cafini5, A Rábano6, M Llorens-Martín1,3.   

Abstract

Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease, dementia with Lewy bodies, and frontotemporal dementia, we studied postmortem human samples. We found that adult-born dentate granule cells showed abnormal morphological development and changes in the expression of differentiation markers. The ratio of quiescent to proliferating hippocampal neural stem cells shifted, and the homeostasis of the neurogenic niche was altered. Aging and neurodegenerative diseases reduced the phagocytic capacity of microglia, triggered astrogliosis, and altered the microvasculature of the dentate gyrus. Thus, enhanced vulnerability of AHN to neurodegeneration might underlie hippocampal dysfunction during physiological and pathological aging in humans.

Entities:  

Mesh：

Year:  2021        PMID： 34672693      PMCID： PMC7613437          DOI： 10.1126/science.abl5163

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   63.714


  34 in total

1.  Human Hippocampal Neurogenesis Persists throughout Aging.

Authors:  Maura Boldrini; Camille A Fulmore; Alexandria N Tartt; Laika R Simeon; Ina Pavlova; Verica Poposka; Gorazd B Rosoklija; Aleksandar Stankov; Victoria Arango; Andrew J Dwork; René Hen; J John Mann
Journal:  Cell Stem Cell       Date:  2018-04-05       Impact factor: 24.633

Review 2.  Staging of Alzheimer's disease-related neurofibrillary changes.

Authors:  H Braak; E Braak
Journal:  Neurobiol Aging       Date:  1995 May-Jun       Impact factor: 4.673

3.  Dopamine depletion impairs precursor cell proliferation in Parkinson disease.

Authors:  Günter U Höglinger; Pamela Rizk; Marie P Muriel; Charles Duyckaerts; Wolfgang H Oertel; Isabelle Caille; Etienne C Hirsch
Journal:  Nat Neurosci       Date:  2004-06-13       Impact factor: 24.884

4.  Hippocampal pathology in amyotrophic lateral sclerosis: selective vulnerability of subfields and their associated projections.

Authors:  Foteini Christidi; Efstratios Karavasilis; Michail Rentzos; Georgios Velonakis; Vasiliki Zouvelou; Sofia Xirou; Georgios Argyropoulos; Ioannis Papatriantafyllou; Varvara Pantolewn; Panagiotis Ferentinos; Nikolaos Kelekis; Ioannis Seimenis; Ioannis Evdokimidis; Peter Bede
Journal:  Neurobiol Aging       Date:  2019-09-23       Impact factor: 4.673

5.  Unraveling human adult hippocampal neurogenesis.

Authors:  Miguel Flor-García; Julia Terreros-Roncal; Elena P Moreno-Jiménez; Jesús Ávila; Alberto Rábano; María Llorens-Martín
Journal:  Nat Protoc       Date:  2020-01-08       Impact factor: 13.491

6.  Resolving cellular and molecular diversity along the hippocampal anterior-to-posterior axis in humans.

Authors:  Fatma Ayhan; Ashwinikumar Kulkarni; Stefano Berto; Karthigayini Sivaprakasam; Connor Douglas; Bradley C Lega; Genevieve Konopka
Journal:  Neuron       Date:  2021-05-28       Impact factor: 18.688

7.  Absence of CX3CR1 impairs the internalization of Tau by microglia.

Authors:  Marta Bolós; María Llorens-Martín; Juan Ramón Perea; Jerónimo Jurado-Arjona; Alberto Rábano; Félix Hernández; Jesús Avila
Journal:  Mol Neurodegener       Date:  2017-08-15       Impact factor: 14.195

8.  Huntington's disease patients display progressive deficits in hippocampal-dependent cognition during a task of spatial memory.

Authors:  Kate L Harris; Matthew Armstrong; Rachel Swain; Sharon Erzinclioglu; Tilak Das; Neil Burgess; Roger A Barker; Sarah L Mason
Journal:  Cortex       Date:  2019-08-13       Impact factor: 4.027

9.  Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.

Authors:  Hiroyuki Konishi; Takayuki Okamoto; Yuichiro Hara; Okiru Komine; Hiromi Tamada; Mitsuyo Maeda; Fumika Osako; Masaaki Kobayashi; Akira Nishiyama; Yosky Kataoka; Toshiyuki Takai; Nobuyuki Udagawa; Steffen Jung; Keiko Ozato; Tomohiko Tamura; Makoto Tsuda; Koji Yamanaka; Tomoo Ogi; Katsuaki Sato; Hiroshi Kiyama
Journal:  EMBO J       Date:  2020-09-22       Impact factor: 11.598
View more
  27 in total

1.  Neurogenesis altered in multiple neurodegenerative diseases.

Authors:  Ian Fyfe
Journal:  Nat Rev Neurol       Date:  2021-12       Impact factor: 42.937

Review 2.  Ageing and rejuvenation of tissue stem cells and their niches.

Authors:  Anne Brunet; Margaret A Goodell; Thomas A Rando
Journal:  Nat Rev Mol Cell Biol       Date:  2022-07-20       Impact factor: 113.915

3.  Human adult hippocampal neurogenesis is back, again?

Authors:  Hai-Kun Liu
Journal:  Cell Res       Date:  2022-09       Impact factor: 46.297

4.  Molecular landscapes of human hippocampal immature neurons across lifespan.

Authors:  Yi Zhou; Yijing Su; Shiying Li; Benjamin C Kennedy; Daniel Y Zhang; Allison M Bond; Yusha Sun; Fadi Jacob; Lu Lu; Peng Hu; Angela N Viaene; Ingo Helbig; Sudha K Kessler; Timothy Lucas; Ryan D Salinas; Xiaosong Gu; H Isaac Chen; Hao Wu; Joel E Kleinman; Thomas M Hyde; David W Nauen; Daniel R Weinberger; Guo-Li Ming; Hongjun Song
Journal:  Nature       Date:  2022-07-06       Impact factor: 69.504

5.  Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".

Authors:  J Terreros-Roncal; E P Moreno-Jiménez; M Flor-García; C B Rodríguez-Moreno; M F Trinchero; B Márquez-Valadez; F Cafini; A Rábano; M Llorens-Martín
Journal:  Science       Date:  2022-04-15       Impact factor: 63.714

6.  Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations.

Authors:  Zhao-Zhe Hao; Jia-Ru Wei; Dongchang Xiao; Ruifeng Liu; Nana Xu; Lei Tang; Mengyao Huang; Yuhui Shen; Changsheng Xing; Wanjing Huang; Xialin Liu; Mengqing Xiang; Yizhi Liu; Zhichao Miao; Sheng Liu
Journal:  Nat Neurosci       Date:  2022-05-30       Impact factor: 28.771

7.  Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis.

Authors:  Yuan-Hung Lin King; Chao Chen; John V Lin King; Jeffrey Simms; Edward Glasscock; Shi-Bing Yang; Yuh-Nung Jan; Lily Y Jan
Journal:  Proc Natl Acad Sci U S A       Date:  2022-05-25       Impact factor: 12.779

8.  Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".

Authors:  J Terreros-Roncal; E P Moreno-Jiménez; M Flor-García; C B Rodríguez-Moreno; M F Trinchero; B Márquez-Valadez; F Cafini; A Rábano; M Llorens-Martín
Journal:  Science       Date:  2022-04-15       Impact factor: 63.714

Review 9.  Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications.

Authors:  Alexandria N Tartt; Madeline B Mariani; Rene Hen; J John Mann; Maura Boldrini
Journal:  Mol Psychiatry       Date:  2022-03-30       Impact factor: 13.437

Review 10.  Chemotherapy-Induced Cognitive Impairment and Hippocampal Neurogenesis: A Review of Physiological Mechanisms and Interventions.

Authors:  Melanie J Sekeres; Meenakshie Bradley-Garcia; Alonso Martinez-Canabal; Gordon Winocur
Journal:  Int J Mol Sci       Date:  2021-11-24       Impact factor: 5.923
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.