Literature DB >> 34663551

Ragulator-Rag and ROS TORment gasdermin D pore formation.

Venkat Giri Magupalli1, Pietro Fontana2, Hao Wu3.   

Abstract

Upon cleavage, the Gasdermin D (GSDMD) N-terminal fragment assembles into pores on the plasma membrane to orchestrate the lytic cell death known as pyroptosis. In a recent article, Evavold et al. showed that the Ragulator-Rag-mTORC1-ROS pathway controls the transition from cleavage and membrane localization to oligomerization and pore formation.
Copyright © 2021 Elsevier Ltd. All rights reserved.

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Year:  2021        PMID： 34663551      PMCID： PMC8643276          DOI： 10.1016/j.it.2021.09.014

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  11 in total

1.  Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

Authors:  Jianjin Shi; Yue Zhao; Kun Wang; Xuyan Shi; Yue Wang; Huanwei Huang; Yinghua Zhuang; Tao Cai; Fengchao Wang; Feng Shao
Journal:  Nature       Date:  2015-09-16       Impact factor: 49.962

2.  Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

Authors:  Nobuhiko Kayagaki; Irma B Stowe; Bettina L Lee; Karen O'Rourke; Keith Anderson; Søren Warming; Trinna Cuellar; Benjamin Haley; Merone Roose-Girma; Qui T Phung; Peter S Liu; Jennie R Lill; Hong Li; Jiansheng Wu; Sarah Kummerfeld; Juan Zhang; Wyne P Lee; Scott J Snipas; Guy S Salvesen; Lucy X Morris; Linda Fitzgerald; Yafei Zhang; Edward M Bertram; Christopher C Goodnow; Vishva M Dixit
Journal:  Nature       Date:  2015-09-16       Impact factor: 49.962

3.  Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis.

Authors:  Joseph K Rathkey; Junjie Zhao; Zhonghua Liu; Yinghua Chen; Jie Yang; Hannah C Kondolf; Bryan L Benson; Steven M Chirieleison; Alex Y Huang; George R Dubyak; Tsan S Xiao; Xiaoxia Li; Derek W Abbott
Journal:  Sci Immunol       Date:  2018-08-24

4.  Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.

Authors:  Xing Liu; Zhibin Zhang; Jianbin Ruan; Youdong Pan; Venkat Giri Magupalli; Hao Wu; Judy Lieberman
Journal:  Nature       Date:  2016-07-07       Impact factor: 49.962

5.  Succination inactivates gasdermin D and blocks pyroptosis.

Authors:  Fiachra Humphries; Liraz Shmuel-Galia; Natalia Ketelut-Carneiro; Sheng Li; Bingwei Wang; Venkatesh V Nemmara; Ruth Wilson; Zhaozhao Jiang; Farnaz Khalighinejad; Khaja Muneeruddin; Scott A Shaffer; Ranjan Dutta; Carolina Ionete; Scott Pesiridis; Shuo Yang; Paul R Thompson; Katherine A Fitzgerald
Journal:  Science       Date:  2020-08-20       Impact factor: 47.728

6.  Gasdermin D pore structure reveals preferential release of mature interleukin-1.

Authors:  Shiyu Xia; Zhibin Zhang; Venkat Giri Magupalli; Juan Lorenzo Pablo; Ying Dong; Setu M Vora; Longfei Wang; Tian-Min Fu; Matthew P Jacobson; Anna Greka; Judy Lieberman; Jianbin Ruan; Hao Wu
Journal:  Nature       Date:  2021-04-21       Impact factor: 49.962

7.  Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.

Authors:  Kendall J Condon; Jose M Orozco; Charles H Adelmann; Jessica B Spinelli; Pim W van der Helm; Justin M Roberts; Tenzin Kunchok; David M Sabatini
Journal:  Proc Natl Acad Sci U S A       Date:  2021-01-26       Impact factor: 12.779

8.  A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system.

Authors:  Martin W LaFleur; Thao H Nguyen; Matthew A Coxe; Kathleen B Yates; Justin D Trombley; Sarah A Weiss; Flavian D Brown; Jacob E Gillis; Daniel J Coxe; John G Doench; W Nicholas Haining; Arlene H Sharpe
Journal:  Nat Commun       Date:  2019-04-10       Impact factor: 14.919

9.  Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.

Authors:  Charles L Evavold; Iva Hafner-Bratkovič; Pascal Devant; Jasmin M D'Andrea; Elsy M Ngwa; Elvira Boršić; John G Doench; Martin W LaFleur; Arlene H Sharpe; Jay R Thiagarajah; Jonathan C Kagan
Journal:  Cell       Date:  2021-07-21       Impact factor: 66.850

Review 10.  Channelling inflammation: gasdermins in physiology and disease.

Authors:  Xing Liu; Shiyu Xia; Zhibin Zhang; Hao Wu; Judy Lieberman
Journal:  Nat Rev Drug Discov       Date:  2021-03-10       Impact factor: 112.288
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  1 in total

Review 1.  Pyroptosis and Its Role in SARS-CoV-2 Infection.

Authors:  Zsofia Agnes Bittner; Markus Schrader; Shilpa Elizabeth George; Ralf Amann
Journal:  Cells       Date:  2022-05-23       Impact factor: 7.666
  1 in total

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