| Literature DB >> 34655926 |
Wenhao Jiang1, Kelly Rootes-Murdy2, Jiayu Chen3, Nora I Perrone- Bizzozero4, Vince D Calhoun3, Theo G M van Erp5, Stefan Ehrlich6, Ingrid Agartz7, Erik G Jönsson8, Ole A Andreassen9, Lei Wang10, Godfrey D Pearlson11, David C Glahn12, Elliot Hong13, Jingyu Liu3, Jessica A Turner14.
Abstract
The direct effect of genetic variations on clinical phenotypes within schizophrenia (SZ) remains elusive. We examined the previously identified association of reduced gray matter concentration in the insula - medial prefrontal cortex and a quantitative trait locus located in 12q24 in a SZ dataset. The main analysis was performed on 1461 SNPs and 830 participants. The highest contributing SNPs were localized in five genes including TMEM119, which encodes a microglial marker, that is associated with neuroinflammation and Alzheimer's disease. The gene set in 12q4 may partially explain brain alterations in SZ, but they may also relate to other psychiatric and developmental disorders.Entities:
Keywords: Insula; QTL; Schizophrenia
Mesh：
Year: 2021 PMID： 34655926 PMCID： PMC8643340 DOI： 10.1016/j.psychres.2021.114237
Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222