| Literature DB >> 27918536 |
Min-Tzu Lo1, David A Hinds2, Joyce Y Tung2, Carol Franz3, Chun-Chieh Fan1,4, Yunpeng Wang5,6,7, Olav B Smeland6,7, Andrew Schork1,4, Dominic Holland5, Karolina Kauppi1,8, Nilotpal Sanyal1, Valentina Escott-Price9, Daniel J Smith10, Michael O'Donovan9, Hreinn Stefansson11, Gyda Bjornsdottir11, Thorgeir E Thorgeirsson11, Kari Stefansson11, Linda K McEvoy1, Anders M Dale1,3,5, Ole A Andreassen6,7, Chi-Hua Chen1.
Abstract
Personality is influenced by genetic and environmental factors and associated with mental health. However, the underlying genetic determinants are largely unknown. We identified six genetic loci, including five novel loci, significantly associated with personality traits in a meta-analysis of genome-wide association studies (N = 123,132-260,861). Of these genome-wide significant loci, extraversion was associated with variants in WSCD2 and near PCDH15, and neuroticism with variants on chromosome 8p23.1 and in L3MBTL2. We performed a principal component analysis to extract major dimensions underlying genetic variations among five personality traits and six psychiatric disorders (N = 5,422-18,759). The first genetic dimension separated personality traits and psychiatric disorders, except that neuroticism and openness to experience were clustered with the disorders. High genetic correlations were found between extraversion and attention-deficit-hyperactivity disorder (ADHD) and between openness and schizophrenia and bipolar disorder. The second genetic dimension was closely aligned with extraversion-introversion and grouped neuroticism with internalizing psychopathology (e.g., depression or anxiety).Entities:
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Year: 2016 PMID： 27918536 PMCID： PMC5278898 DOI： 10.1038/ng.3736
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330