Pei-Kang Liu1,2,3,4, Yo-Chen Chang1,2, Nan-Kai Wang4, Joseph Ryu4, Rong-Kung Tsai5,6, Shiuh-Liang Hsu1,2, Jen-Yu Hung2,7,8, Chung-Yao Hsu2,9,10, Ming-Hong Tai3,11,12, Ming-Ju Tsai2,7,8,10,13. 1. Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. 2. School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. 3. Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan. 4. Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University, New York, New York. 5. Institute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. 6. Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. 7. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. 8. Department of Respiratory Care, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. 9. Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. 10. Sleep Disorders Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. 11. Center for Neuroscience, National Sun Yat-sen University, Kaohsiung, Taiwan. 12. Graduate Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung, Taiwan. 13. Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Abstract
STUDY OBJECTIVES: The association between sleep apnea (SA) and cataract was confirmed in a comprehensive large-scale study. This study aimed to investigate whether SA was associated with increased risk of cataract. METHODS: The 18-year nationwide retrospective population-based cohort study used data retrieved from the Taiwan National Health Insurance Database. We selected adult patients with a diagnosis of SA, based on diagnostic codes (suspected SA cohort) or on presence of diagnosis after polysomnography (SA cohort), and matched each of them to 5 randomly selected, and age- and sex-matched control participants. The incidence rate of cataract was compared between patients with SA and the controls. The effect of SA on incident cataract was assessed using multivariable Poisson regression and Cox regression analyses. RESULTS: A total of 6,438 patients in the suspected SA cohort were matched with 32,190 controls (control A cohort), including 3,616 patients in the SA cohort matched with 18,080 controls (control B cohort). After adjusting for age, sex, residency, income level, and comorbidities, the incidence rates of cataract were significantly higher in the SA cohorts than in the corresponding control cohorts. SA was an independent risk factor for incident cataract (adjusted hazard ratio [95% confidence interval]: 1.4 [1.2-1.6]). In patients with SA, elder age, heart disease, chronic pulmonary disease, and diabetes mellitus were independent risk factors for incident cataract. CONCLUSIONS: Our study revealed a significantly higher risk for developing cataract in patients with SA. Physicians caring for patients with SA should be aware of this ophthalmic complication. CITATION: Liu P-K, Chang Y-C, Wang N-K, et al. The association between cataract and sleep apnea: a nationwide population-based cohort study. J Clin Sleep Med. 2022;18(3):769-777.
STUDY OBJECTIVES: The association between sleep apnea (SA) and cataract was confirmed in a comprehensive large-scale study. This study aimed to investigate whether SA was associated with increased risk of cataract. METHODS: The 18-year nationwide retrospective population-based cohort study used data retrieved from the Taiwan National Health Insurance Database. We selected adult patients with a diagnosis of SA, based on diagnostic codes (suspected SA cohort) or on presence of diagnosis after polysomnography (SA cohort), and matched each of them to 5 randomly selected, and age- and sex-matched control participants. The incidence rate of cataract was compared between patients with SA and the controls. The effect of SA on incident cataract was assessed using multivariable Poisson regression and Cox regression analyses. RESULTS: A total of 6,438 patients in the suspected SA cohort were matched with 32,190 controls (control A cohort), including 3,616 patients in the SA cohort matched with 18,080 controls (control B cohort). After adjusting for age, sex, residency, income level, and comorbidities, the incidence rates of cataract were significantly higher in the SA cohorts than in the corresponding control cohorts. SA was an independent risk factor for incident cataract (adjusted hazard ratio [95% confidence interval]: 1.4 [1.2-1.6]). In patients with SA, elder age, heart disease, chronic pulmonary disease, and diabetes mellitus were independent risk factors for incident cataract. CONCLUSIONS: Our study revealed a significantly higher risk for developing cataract in patients with SA. Physicians caring for patients with SA should be aware of this ophthalmic complication. CITATION: Liu P-K, Chang Y-C, Wang N-K, et al. The association between cataract and sleep apnea: a nationwide population-based cohort study. J Clin Sleep Med. 2022;18(3):769-777.
Authors: Ava Grace Tan; Yih Chung Tham; Miao Li Chee; Paul Mitchell; Robert G Cumming; Charumathi Sabanayagam; Tien Y Wong; Jie Jin Wang; Ching-Yu Cheng Journal: Clin Exp Ophthalmol Date: 2020-05-04 Impact factor: 4.207
Authors: Joan Sweeney; Chris C Patterson; Andrew Menzies-Gow; Rob M Niven; Adel H Mansur; Christine Bucknall; Rekha Chaudhuri; David Price; Chris E Brightling; Liam G Heaney Journal: Thorax Date: 2016-01-27 Impact factor: 9.139