| Literature DB >> 34631977 |
Tiago S Salles1, Marcelo D F Meneses1, Kristie A Yamamoto1, Thayane E Sá-Guimarães1, Lucio Ayres Caldas2,3, Jessica H S Silva4, Polianna da Silva Ferreira5, Ana Claudia F Amaral6, José A Ventura7, Renata Campos Azevedo1, Ricardo M Kuster4,5, Márcia R Soares8, Davis F Ferreira1,2,9.
Abstract
Brazilian traditional medicine has explored the antiviral properties of many plant extracts, including those from the Brazilian pepper tree, Schinus terebinthifolius. In the present study, we investigated the chemical composition and anti-mayaro virus (MAYV) activity of S. terebinthifolius fruit. Extensive virucidal activity (more than 95%) was detected for the ethyl acetate extract and the isolated biflavonoids. From the ethyl acetate extract of Schinus terebinthifolius fruits, two bioflavonoids were isolated ((2S, 2″S)-2,3,2″,3″-tetrahydroamentoflavone and agathisflavone), which showed strong virucidal activity against Mayaro virus. Furthermore, several other compounds like terpenes and phenolics were identified by hyphenated techniques (GC-MS, LC-MS and HPLC-UV), as well as by mass spectrometry. Immunofluorescence assay confirmed antiviral activity and transmission electron microscopy revealed damage in viral particles treated with biflavonoids. The data suggest the direct action of the extract and the biflavonoids on the virus particles. The biflavonoids tetrahydroamentoflavone and agathisflavone had strong virucidal activity and reduced MAYV infection. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13337-021-00698-z. © Indian Virological Society 2021.Entities:
Keywords: Antiviral; Biflavonoids; Schinus terebinthifolius; Virus mayaro
Year: 2021 PMID： 34631977 PMCID： PMC8473526 DOI： 10.1007/s13337-021-00698-z
Source DB: PubMed Journal: Virusdisease ISSN： 2347-3584