| Literature DB >> 16428025 |
B Weniger1, C Vonthron-Sénécheau, M Kaiser, R Brun, R Anton.
Abstract
The antiplasmodial, leishmanicidal and antitrypanosomal activities of eight natural biflavonoids were estimated in vitro on a chloroquine-resistant strain of Plasmodium falciparum, axenically grown Leishmania donovani amastigotes and Trypanosoma cruzi trypomastigotes and Trypanosoma brucei rhodesiense bloodstream forms. Lanaroflavone showed the highest antiplasmodial activity (IC(50) = 0.48 microM), isoginkgetin was the most active leishmanicidal compound (IC(50) = 1.9 microM), whereas ginkgetin (IC(50) = 11 microM) and isoginkgetin (IC(50) = 13 microM) showed the best antitrypanosomal activity in our assays. The cytotoxicity and the selectivity indices for the most active compounds were also estimated. Lanaroflavone exhibited a high selectivity index value (SI = 159), indicating selective antiplasmodial activity.Entities:
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Year: 2005 PMID： 16428025 DOI： 10.1016/j.phymed.2004.10.008
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340