Literature DB >> 34631497

Trans-disciplinary diagnosis for an in-depth reform of regulatory expertise in the field of environmental toxicology and security.

Joël Spiroux de Vendômois1, Jean-Paul Bourdineaud2, Arnaud Apoteker1, Nicolas Defarge1,3, Emilie Gaillard1,4, Corinne Lepage1, Jacques Testart1,5, Christian Vélot1,5,6,7.   

Abstract

Repeated health and environmental scandals, the loss of biodiversity and the recent burst of chronic diseases constantly remind us the inability of public authorities and risk assessment agencies to protect health and the environment. After reviewing the main shortcomings of our evaluation system of chemicals and new technologies, supported by some concrete examples, we develop a number of proposals to reform both the risk assessment agencies and the evaluation processes. We especially propose the establishment of an independent structure, a High Authority of Expertise, supervising, either at European level or at national level, all the evaluation agencies, and ensuring the transparency, the methodology and the deontology of the expertise. In addition to modifying the evaluation protocols, both in their nature and in their content, especially in order to adapt them to current pollutants such as endocrine disruptors, we propose a reform of the expertise processes based on transparency, contradiction, and greater democracy, including close collaboration between the institutional and scientific parties on the one hand and the whole civil society on the other. All the proposals we make are inspired by the desire to prevent, through appropriate mechanisms, the human, health, ecological, but also economic consequences of contemporary technological choices. © Korean Society of Toxicology 2021.

Entities:  

Keywords:  Conflict of interest; Deontology; Endocrine disrupter; High Authority of Expertise; Pesticide; Regulatory evaluation

Year:  2021        PMID: 34631497      PMCID: PMC8476664          DOI: 10.1007/s43188-020-00075-w

Source DB:  PubMed          Journal:  Toxicol Res        ISSN: 1976-8257


  98 in total

1.  Incidence and Mortality and Epidemiology of Breast Cancer in the World.

Authors:  Mahshid Ghoncheh; Zahra Pournamdar; Hamid Salehiniya
Journal:  Asian Pac J Cancer Prev       Date:  2016

Review 2.  [Impact of endocrine disrupting chemicals on birth outcomes].

Authors:  E Chen Zee; P Cornet; G Lazimi; C Rondet; M Lochard; A M Magnier; G Ibanez
Journal:  Gynecol Obstet Fertil       Date:  2013-10-09

3.  Is Hypospadias Associated with Prenatal Exposure to Endocrine Disruptors? A French Collaborative Controlled Study of a Cohort of 300 Consecutive Children Without Genetic Defect.

Authors:  Nicolas Kalfa; Françoise Paris; Pascal Philibert; Mattea Orsini; Sylvie Broussous; Nadège Fauconnet-Servant; Françoise Audran; Laura Gaspari; Hélène Lehors; Myriam Haddad; Jean-Michel Guys; Rachel Reynaud; Pierre Alessandrini; Thierry Merrot; Kathy Wagner; Jean-Yves Kurzenne; Florence Bastiani; Jean Bréaud; Jean-Stéphane Valla; Gérard Morisson Lacombe; Eric Dobremez; Amel Zahhaf; Jean-Pierre Daures; Charles Sultan
Journal:  Eur Urol       Date:  2015-05-23       Impact factor: 20.096

4.  Male reproductive disorders, diseases, and costs of exposure to endocrine-disrupting chemicals in the European Union.

Authors:  Russ Hauser; Niels E Skakkebaek; Ulla Hass; Jorma Toppari; Anders Juul; Anna Maria Andersson; Andreas Kortenkamp; Jerrold J Heindel; Leonardo Trasande
Journal:  J Clin Endocrinol Metab       Date:  2015-03-05       Impact factor: 5.958

Review 5.  Roundup litigation discovery documents: implications for public health and journal ethics.

Authors:  Sheldon Krimsky; Carey Gillam
Journal:  J Public Health Policy       Date:  2018-08       Impact factor: 2.222

6.  Altered gut microbiota and activity in a murine model of autism spectrum disorders.

Authors:  Caroline G M de Theije; Harm Wopereis; Mohamed Ramadan; Tiemen van Eijndthoven; Jolanda Lambert; Jan Knol; Johan Garssen; Aletta D Kraneveld; Raish Oozeer
Journal:  Brain Behav Immun       Date:  2013-12-11       Impact factor: 7.217

7.  Neurobehavioral deficits, diseases, and associated costs of exposure to endocrine-disrupting chemicals in the European Union.

Authors:  Martine Bellanger; Barbara Demeneix; Philippe Grandjean; R Thomas Zoeller; Leonardo Trasande
Journal:  J Clin Endocrinol Metab       Date:  2015-03-05       Impact factor: 5.958

Review 8.  Epigenetics and the Developmental Origins of Health and Disease: Parental environment signalling to the epigenome, critical time windows and sculpting the adult phenotype.

Authors:  Sofiane Safi-Stibler; Anne Gabory
Journal:  Semin Cell Dev Biol       Date:  2019-10-04       Impact factor: 7.727

9.  Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.

Authors:  Brittany M Angle; Rylee Phuong Do; Davide Ponzi; Richard W Stahlhut; Bertram E Drury; Susan C Nagel; Wade V Welshons; Cynthia L Besch-Williford; Paola Palanza; Stefano Parmigiani; Frederick S vom Saal; Julia A Taylor
Journal:  Reprod Toxicol       Date:  2013-07-25       Impact factor: 3.143

Review 10.  Literature review of the burden of prostate cancer in Germany, France, the United Kingdom and Canada.

Authors:  J Smith-Palmer; C Takizawa; W Valentine
Journal:  BMC Urol       Date:  2019-03-18       Impact factor: 2.264

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