BACKGROUND: Endocrine disruptors are ubiquitous chemicals contaminants in the environment, wildlife, and humans. Their adverse effects on reproduction are well-documented. There is growing evidence that they can contribute to the current emergence of chronic diseases. OBJECTIVES: Our aim is to assess the relationships between endocrine disruptors and the neonatal health outcomes. METHODS: Two persons have independently reviewed Medline and Toxline databases about the following pollutants: bisphenol A, phthalates, parabens, brominated flame retardants and perfluorinated compounds. Only the human epidemiological studies, in general population with an abstract available, published between 2007 January the 1st and 2011 December the 31st, were analysed. The quality of each study was assessed with the Strobe score. RESULTS: Twenty-five out of 680 studies were included in the analysis. All pollutants were widely detected in maternal and new borns samples. Most of the studies have shown associations between bisphenol A, brominated flame retardants and perfluorinated compounds and lower birth weight. The effects on gestational age were less documented and have shown no clear connection. Results for phthalates were more ambiguous. Only one non-instructive study was found on parabens. DISCUSSION: Due to the inherent methological bias on endocrine disruptors research, further additional studies on environmental health must be investigated. It seems necessary to adopt preventive health measures first for vulnerable population.
BACKGROUND: Endocrine disruptors are ubiquitous chemicals contaminants in the environment, wildlife, and humans. Their adverse effects on reproduction are well-documented. There is growing evidence that they can contribute to the current emergence of chronic diseases. OBJECTIVES: Our aim is to assess the relationships between endocrine disruptors and the neonatal health outcomes. METHODS: Two persons have independently reviewed Medline and Toxline databases about the following pollutants: bisphenol A, phthalates, parabens, brominated flame retardants and perfluorinated compounds. Only the human epidemiological studies, in general population with an abstract available, published between 2007 January the 1st and 2011 December the 31st, were analysed. The quality of each study was assessed with the Strobe score. RESULTS: Twenty-five out of 680 studies were included in the analysis. All pollutants were widely detected in maternal and new borns samples. Most of the studies have shown associations between bisphenol A, brominated flame retardants and perfluorinated compounds and lower birth weight. The effects on gestational age were less documented and have shown no clear connection. Results for phthalates were more ambiguous. Only one non-instructive study was found on parabens. DISCUSSION: Due to the inherent methological bias on endocrine disruptors research, further additional studies on environmental health must be investigated. It seems necessary to adopt preventive health measures first for vulnerable population.
Authors: Jason F Ohlstein; Amy L Strong; John A McLachlan; Jeffrey M Gimble; Matthew E Burow; Bruce A Bunnell Journal: J Mol Endocrinol Date: 2014-08-20 Impact factor: 5.098
Authors: Joël Spiroux de Vendômois; Jean-Paul Bourdineaud; Arnaud Apoteker; Nicolas Defarge; Emilie Gaillard; Corinne Lepage; Jacques Testart; Christian Vélot Journal: Toxicol Res Date: 2021-01-25
Authors: Laura Birks; Maribel Casas; Ana M Garcia; Jan Alexander; Henrique Barros; Anna Bergström; Jens Peter Bonde; Alex Burdorf; Nathalie Costet; Asta Danileviciute; Merete Eggesbø; Mariana F Fernández; M Carmen González-Galarzo; Wojciech Hanke; Vincent Jaddoe; Manolis Kogevinas; Inger Kull; Aitana Lertxundi; Vasiliki Melaki; Anne-Marie Nybo Andersen; Nicolás Olea; Kinga Polanska; Franca Rusconi; Loreto Santa-Marina; Ana Cristina Santos; Tanja Vrijkotte; Daniela Zugna; Mark Nieuwenhuijsen; Sylvaine Cordier; Martine Vrijheid Journal: Environ Health Perspect Date: 2016-05-06 Impact factor: 9.031
Authors: C Polevoy; T E Arbuckle; Y Oulhote; B P Lanphear; K A Cockell; G Muckle; D Saint-Amour Journal: Environ Health Date: 2020-02-07 Impact factor: 5.984
Authors: Amin Salehpour; Farzad Shidfar; Mehdi Hedayati; Asal Neshatbini Tehrani; Ali Asghar Farshad; Saeed Mohammadi Journal: Genes Environ Date: 2020-03-11