| Literature DB >> 34627874 |
Stanislovas S Jankauskas1, Urna Kansakar1, Fahimeh Varzideh1, Scott Wilson2, Pasquale Mone2, Angela Lombardi2, Jessica Gambardella3, Gaetano Santulli4.
Abstract
Heart failure and cardiovascular disorders represent the leading cause of death in diabetic patients. Here we present a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect the mechanisms of this complex disease, we conclude with a section on the most recent updates of the literature on clinical management.Entities:
Keywords: Adrenergic receptors; Aging; BHB; Bioenergetics; Cardiomyocytes; Cardiovascular endocrinology; Diabetes mellitus; Diabetic cardiomyopathy; Diastolic dysfunction; Endothelium; FOXO1; Fibroblasts; Fibrosis; HFpEF; Heart failure; Mitochondria; NADH; Oxidative stress; ROS; Senescence; T1DM; T2DM; VSMC
Mesh：
Year: 2021 PMID： 34627874 PMCID： PMC8941799 DOI： 10.1016/j.metabol.2021.154910
Source DB: PubMed Journal: Metabolism ISSN： 0026-0495 Impact factor: 8.694