Yasunori Yamamoto1, Shinya Furukawa2, Junichi Watanabe3, Aki Kato4, Katsunori Kusumoto4, Teruki Miyake5, Eiji Takeshita6, Yoshio Ikeda1, Naofumi Yamamoto7, Katsutoshi Okada8, Katsuhiko Kohara9, Syuichi Saheki4, Yuka Saeki4,10, Yoichi Hiasa5. 1. Endoscopy Center, Ehime University Hospital, Toon, Ehime, Japan. 2. Health Services Center, Ehime University, Matsuyama, Ehime, 790-8577, Japan. shinya.furukawa@gmail.com. 3. Department of Rehabilitation, Ehime Prefectural Central Hospital, Matsuyama, Ehime, Japan. 4. Health Services Center, Ehime University, Matsuyama, Ehime, 790-8577, Japan. 5. Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan. 6. Department of Inflammatory Bowel Diseases and Therapeutics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. 7. Faculty of Collaborative Regional Innovation, Ehime University, Matsuyama, Ehime, Japan. 8. Shikokuchuo Public Health Center, Shikokuchuo, Ehime, Japan. 9. Department of Internal Medicine, Ibusuki Kozenkai Hospital, Ibusuki, Kagoshima, Japan. 10. Community Health Systems for Nursing, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
Abstract
BACKGROUND: Evidence regarding the association between sleep disturbance and functional dyspepsia (FD) remains limited in the young population. AIMS: This study aimed to investigate the association between sleep disturbance and FD including subgroups among Japanese young people. METHODS: Study subjects were 8923 university students. FD was defined according to the Rome III criteria. Subjects with FD were further categorized as having postprandial distress syndrome (PDS) or epigastric pain syndrome (EPS). Subjects completed a self-reported questionnaire assessing self-reported sleep duration, sleep disturbance, difficulty falling asleep, deep sleep disorder, nocturnal awakening, early awakening, and daytime sleepiness. RESULTS: The prevalence of FD was 1.9%. After adjustment, all types of sleep disturbances were independently positively associated with FD (total sleep disturbance: OR 4.11 [95% CI: 2.89-5.78], difficulty falling asleep: OR 3.97 [95% CI: 2.53-6.01], deep sleep disorder: OR 4.85 [95% CI: 3.06-7.40], nocturnal awakening: OR 4.35 [95% CI: 1.90-8.67], early awakening: OR 4.50 [95% CI: 1.97-8.97], and daytime sleepiness: OR 2.83 [95% CI: 1.25-5.56]). While nocturnal awakening and daytime sleepiness were not associated with EPS, the other types of sleep disturbance were independently positively associated with EPS and PDS. No association between self-reported sleep duration and FD was found. CONCLUSIONS: Sleep disturbance may be independently positively associated with the prevalence of FD among Japanese young people. Nocturnal awakening and daytime sleepiness were not associated with EPS; the other types of sleep disturbance were independently positively associated with EPS and PDS.
BACKGROUND: Evidence regarding the association between sleep disturbance and functional dyspepsia (FD) remains limited in the young population. AIMS: This study aimed to investigate the association between sleep disturbance and FD including subgroups among Japanese young people. METHODS: Study subjects were 8923 university students. FD was defined according to the Rome III criteria. Subjects with FD were further categorized as having postprandial distress syndrome (PDS) or epigastric pain syndrome (EPS). Subjects completed a self-reported questionnaire assessing self-reported sleep duration, sleep disturbance, difficulty falling asleep, deep sleep disorder, nocturnal awakening, early awakening, and daytime sleepiness. RESULTS: The prevalence of FD was 1.9%. After adjustment, all types of sleep disturbances were independently positively associated with FD (total sleep disturbance: OR 4.11 [95% CI: 2.89-5.78], difficulty falling asleep: OR 3.97 [95% CI: 2.53-6.01], deep sleep disorder: OR 4.85 [95% CI: 3.06-7.40], nocturnal awakening: OR 4.35 [95% CI: 1.90-8.67], early awakening: OR 4.50 [95% CI: 1.97-8.97], and daytime sleepiness: OR 2.83 [95% CI: 1.25-5.56]). While nocturnal awakening and daytime sleepiness were not associated with EPS, the other types of sleep disturbance were independently positively associated with EPS and PDS. No association between self-reported sleep duration and FD was found. CONCLUSIONS: Sleep disturbance may be independently positively associated with the prevalence of FD among Japanese young people. Nocturnal awakening and daytime sleepiness were not associated with EPS; the other types of sleep disturbance were independently positively associated with EPS and PDS.
Authors: Santhi Swaroop Vege; G Richard Locke; Amy L Weaver; Sara A Farmer; L Joseph Melton; Nicholas J Talley Journal: Mayo Clin Proc Date: 2004-12 Impact factor: 7.616