Jong Kyu Park1, Kyu Chan Huh2, Joong Goo Kwon3, Kee Wook Jung4, Jung Hwan Oh5, Kyung Ho Song2, Kyoungwon Jung6, Ki Bae Bang7, Ju Yup Lee8, Chung Hyun Tae9, Cheol Min Shin10, Jong Wook Kim11, Hyuk Lee12. 1. Department of Gastroenterology, Ulsan University College of Medicine, Gangneung Asan Hospital, Gangneung, South Korea. 2. Department of Gastroenterology, Konyang University Hospital, Daejeon, South Korea. 3. Department of Gastroenterology, College of Medicine, Catholic University of Daegu, Daegu, South Korea. 4. Department of Gastroenterology, Ulsan University College of Medicine, Asan Medical Center, Seoul, South Korea. 5. Department of Gastroenterology, College of Medicine, Eunpyeong St. Mary's Hospital, Catholic University of Korea, Seoul, South Korea. 6. Department of Gastroenterology, College of Medicine, Kosin University, Pusan, South Korea. 7. Department of Gastroenterology, College of Medicine, Dankook University, Cheonan, South Korea. 8. Department of Gastroenterology, College of Medicine, Keimyung University, Daegu, South Korea. 9. Department of Gastroenterology, College of Medicine, Ewha Woman's University, Seoul, South Korea. 10. Department of Gastroenterology, Seoul National University, Bundang Seoul University Hospital, Seongnam, South Korea. 11. Department of Gastroenterology, Inje University Ilsan Paik Hospital, Goyang, South Korea. 12. Department of Gastroenterology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
Abstract
BACKGROUND AND AIM: The few studies concerning the association between sleep disorders and functional dyspepsia (FD) have yielded inconsistent results. We compared the prevalence of sleep disorders in patients with FD and healthy controls, and evaluated whether FD was independently associated with sleep disorders, and the risk factors for sleep disorders in patients with FD. METHODS: This prospective, multicenter, cross-sectional study was conducted from August 2014 to December 2017 at 12 hospitals in South Korea. The inclusion criterion was the presence of FD (for ≥18 years) according to the Rome III criteria. Healthy controls were recruited from among patients who visited the Health Examination Center for check-ups. RESULTS: In total, 526 subjects were prospectively enrolled in this study (201 with FD and 325 healthy controls). The prevalence of sleep disorders was significantly higher among the patients with FD than among the healthy controls (41.8% vs 18.8%, P = 0.000). In a multivariate analysis, FD (odds ratio [OR] = 1.851; 95% confidence interval [CI] 1.194-2.870; P = 0.006), female sex (OR = 1.672; 95% CI 1.063-2.628; P = 0.026), and anxiety (OR = 3.325; 95% CI 2.140-5.166; P = 0.000) were independent risk factors for sleep disorders in the overall cohorts. In patients with FD only, low body mass index, heartburn, and anxiety were independent risk factors for sleep disorders in a further multivariate analysis. CONCLUSION: Sleep disorders were common in patients with FD. FD was significantly associated with sleep disorders in our patient population, irrespective of the presence of heartburn or psychiatric disorders.
BACKGROUND AND AIM: The few studies concerning the association between sleep disorders and functional dyspepsia (FD) have yielded inconsistent results. We compared the prevalence of sleep disorders in patients with FD and healthy controls, and evaluated whether FD was independently associated with sleep disorders, and the risk factors for sleep disorders in patients with FD. METHODS: This prospective, multicenter, cross-sectional study was conducted from August 2014 to December 2017 at 12 hospitals in South Korea. The inclusion criterion was the presence of FD (for ≥18 years) according to the Rome III criteria. Healthy controls were recruited from among patients who visited the Health Examination Center for check-ups. RESULTS: In total, 526 subjects were prospectively enrolled in this study (201 with FD and 325 healthy controls). The prevalence of sleep disorders was significantly higher among the patients with FD than among the healthy controls (41.8% vs 18.8%, P = 0.000). In a multivariate analysis, FD (odds ratio [OR] = 1.851; 95% confidence interval [CI] 1.194-2.870; P = 0.006), female sex (OR = 1.672; 95% CI 1.063-2.628; P = 0.026), and anxiety (OR = 3.325; 95% CI 2.140-5.166; P = 0.000) were independent risk factors for sleep disorders in the overall cohorts. In patients with FD only, low body mass index, heartburn, and anxiety were independent risk factors for sleep disorders in a further multivariate analysis. CONCLUSION:Sleep disorders were common in patients with FD. FD was significantly associated with sleep disorders in our patient population, irrespective of the presence of heartburn or psychiatric disorders.