Literature DB >> 34616863

The concerted action of oncogenic driver mutations directs global translation in intestinal epithelial cells.

Wouter Smit1, Jarom Heijmans1,2.   

Abstract

Oncogenic transformation of colorectal cancer cells is driven by a set of mutations that cause aberrant signaling of growth factor-receptor pathways. Using organoids, we demonstrate that the most frequent driver mutations in APC, KRAS, SMAD4, and TP53 are enhancers of the global mRNA translational capacity, which is linked to intestinal cell growth in an mTOR-dependent manner.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Colorectal cancer; driver mutations; global translation; mTOR signaling; protein synthesis

Year:  2021        PMID： 34616863      PMCID： PMC8489902          DOI： 10.1080/23723556.2021.1879614

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Translational control in cancer.

Authors:  Deborah Silvera; Silvia C Formenti; Robert J Schneider
Journal:  Nat Rev Cancer       Date:  2010-04       Impact factor: 60.716

Review 2.  A genetic model for colorectal tumorigenesis.

Authors:  E R Fearon; B Vogelstein
Journal:  Cell       Date:  1990-06-01       Impact factor: 41.582

3.  Global quantification of mammalian gene expression control.

Authors:  Björn Schwanhäusser; Dorothea Busse; Na Li; Gunnar Dittmar; Johannes Schuchhardt; Jana Wolf; Wei Chen; Matthias Selbach
Journal:  Nature       Date:  2011-05-19       Impact factor: 49.962

4.  Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation.

Authors:  Jooske F van Lidth de Jeude; Claudia N Spaan; Bartolomeus J Meijer; Wouter L Smit; Tanya T D Soeratram; Mattheus C B Wielenga; B Florien Westendorp; Amy S Lee; Sander Meisner; Jacqueline L M Vermeulen; Manon E Wildenberg; Gijs R van den Brink; Vanesa Muncan; Jarom Heijmans
Journal:  Cancer Res       Date:  2018-09-19       Impact factor: 12.701

5.  Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.

Authors:  Alex Kentsis; Ivan Topisirovic; Biljana Culjkovic; Ling Shao; Katherine L B Borden
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-15       Impact factor: 11.205

6.  4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation.

Authors:  Rania Azar; Amandine Alard; Christiane Susini; Corinne Bousquet; Stéphane Pyronnet
Journal:  EMBO J       Date:  2009-10-15       Impact factor: 11.598

7.  An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Authors:  Carson C Thoreen; Seong A Kang; Jae Won Chang; Qingsong Liu; Jianming Zhang; Yi Gao; Laurie J Reichling; Taebo Sim; David M Sabatini; Nathanael S Gray
Journal:  J Biol Chem       Date:  2009-01-15       Impact factor: 5.157

8.  mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

Authors:  Thomas J Jackson; John Rp Knight; William J Faller; Rachel A Ridgway; Thomas Jamieson; Saadia A Karim; Carolyn Jones; Sorina Radulescu; David J Huels; Kevin B Myant; Kate M Dudek; Helen A Casey; Alessandro Scopelliti; Julia B Cordero; Marcos Vidal; Mario Pende; Alexey G Ryazanov; Nahum Sonenberg; Oded Meyuhas; Michael N Hall; Martin Bushell; Anne E Willis; Owen J Sansom
Journal:  Nature       Date:  2014-11-05       Impact factor: 49.962

9.  BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes.

Authors:  Zhen Qi; Yehua Li; Bing Zhao; Chi Xu; Yuan Liu; Haonan Li; Bingjie Zhang; Xinquan Wang; Xiao Yang; Wei Xie; Baojie Li; Jing-Dong Jackie Han; Ye-Guang Chen
Journal:  Nat Commun       Date:  2017-01-06       Impact factor: 14.919
  10 in total

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