Literature DB >> 20332778

Translational control in cancer.

Deborah Silvera1, Silvia C Formenti, Robert J Schneider.   

Abstract

Remarkable progress has been made in defining a new understanding of the role of mRNA translation and protein synthesis in human cancer. Translational control is a crucial component of cancer development and progression, directing both global control of protein synthesis and selective translation of specific mRNAs that promote tumour cell survival, angiogenesis, transformation, invasion and metastasis. Translational control of cancer is multifaceted, involving alterations in translation factor levels and activities unique to different types of cancers, disease stages and the tumour microenvironment. Several clinical efforts are underway to target specific components of the translation apparatus or unique mRNA translation elements for cancer therapeutics.

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Year:  2010        PMID： 20332778     DOI： 10.1038/nrc2824

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  143 in total

1.  Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.

Authors:  A E Koromilas; S Roy; G N Barber; M G Katze; N Sonenberg
Journal:  Science       Date:  1992-09-18       Impact factor: 47.728

2.  The nucleoli of cultured human lymphocytes. I. Nucleolar morphology in relation to transformation and the DNA cycle.

Authors:  R Gani
Journal:  Exp Cell Res       Date:  1976-02       Impact factor: 3.905

Review 3.  Current development of mTOR inhibitors as anticancer agents.

Authors:  Sandrine Faivre; Guido Kroemer; Eric Raymond
Journal:  Nat Rev Drug Discov       Date:  2006-08       Impact factor: 84.694

4.  The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.

Authors:  David Shahbazian; Philippe P Roux; Virginie Mieulet; Michael S Cohen; Brian Raught; Jack Taunton; John W B Hershey; John Blenis; Mario Pende; Nahum Sonenberg
Journal:  EMBO J       Date:  2006-06-08       Impact factor: 11.598

5.  Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.

Authors:  A J Waskiewicz; J C Johnson; B Penn; M Mahalingam; S R Kimball; J A Cooper
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

6.  Role of eIF3 p170 in controlling synthesis of ribonucleotide reductase M2 and cell growth.

Authors:  Zizheng Dong; Lisa H Liu; Baoguang Han; Roxana Pincheira; Jian-Ting Zhang
Journal:  Oncogene       Date:  2004-05-06       Impact factor: 9.867

7.  An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Authors:  Carson C Thoreen; Seong A Kang; Jae Won Chang; Qingsong Liu; Jianming Zhang; Yi Gao; Laurie J Reichling; Taebo Sim; David M Sabatini; Nathanael S Gray
Journal:  J Biol Chem       Date:  2009-01-15       Impact factor: 5.157

8.  Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis.

Authors:  Aurelia Noske; Juliane Lena Lindenberg; Silvia Darb-Esfahani; Wilko Weichert; Ann-Christin Buckendahl; Annika Röske; Jalid Sehouli; Manfred Dietel; Carsten Denkert
Journal:  Oncol Rep       Date:  2008-12       Impact factor: 3.906

9.  Identification of a 170-kDa protein over-expressed in lung cancers.

Authors:  R Pincheira; Q Chen; J T Zhang
Journal:  Br J Cancer       Date:  2001-06-01       Impact factor: 7.640

10.  Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

Authors:  Y L Yang; L F Reis; J Pavlovic; A Aguzzi; R Schäfer; A Kumar; B R Williams; M Aguet; C Weissmann
Journal:  EMBO J       Date:  1995-12-15       Impact factor: 11.598
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  404 in total

1.  Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies.

Authors:  Christina M Rodrigo; Regina Cencic; Stéphane P Roche; Jerry Pelletier; John A Porco
Journal:  J Med Chem       Date:  2011-12-19       Impact factor: 7.446

2.  Emerging therapeutics targeting mRNA translation.

Authors:  Abba Malina; John R Mills; Jerry Pelletier
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-04-01       Impact factor: 10.005

Review 3.  Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping.

Authors:  Sunghoon Kim; Sungyong You; Daehee Hwang
Journal:  Nat Rev Cancer       Date:  2011-09-23       Impact factor: 60.716

Review 4.  Cytoplasmic RNA-binding proteins and the control of complex brain function.

Authors:  Jennifer C Darnell; Joel D Richter
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-08-01       Impact factor: 10.005

5.  Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway.

Authors:  Zineb Mounir; Jothi Latha Krishnamoorthy; Shuo Wang; Barbara Papadopoulou; Shirley Campbell; William J Muller; Maria Hatzoglou; Antonis E Koromilas
Journal:  Sci Signal       Date:  2011-09-27       Impact factor: 8.192

6.  The soy isoflavone equol may increase cancer malignancy via up-regulation of eukaryotic protein synthesis initiation factor eIF4G.

Authors:  Columba de la Parra; Elisa Otero-Franqui; Michelle Martinez-Montemayor; Suranganie Dharmawardhane
Journal:  J Biol Chem       Date:  2012-10-24       Impact factor: 5.157

7.  LINCS gene expression signature analysis revealed bosutinib as a radiosensitizer of breast cancer cells by targeting eIF4G1.

Authors:  Sai Hu; Dafei Xie; Pingkun Zhou; Xiaodan Liu; Xiaoyao Yin; Bo Huang; Hua Guan
Journal:  Int J Mol Med       Date:  2021-03-11       Impact factor: 4.101

8.  Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors.

Authors:  Morgan L Shannon; Ryann M Fame; Kevin F Chau; Neil Dani; Monica L Calicchio; Gwenaelle S Géléoc; Hart G W Lidov; Sanda Alexandrescu; Maria K Lehtinen
Journal:  Am J Pathol       Date:  2018-03-13       Impact factor: 4.307

Review 9.  Metabolic control of autophagy.

Authors:  Lorenzo Galluzzi; Federico Pietrocola; Beth Levine; Guido Kroemer
Journal:  Cell       Date:  2014-12-04       Impact factor: 41.582

10.  Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.

Authors:  Yubao Wang; Michael Begley; Qing Li; Hai-Tsang Huang; Ana Lako; Michael J Eck; Nathanael S Gray; Timothy J Mitchison; Lewis C Cantley; Jean J Zhao
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-15       Impact factor: 11.205
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