| Literature DB >> 34612605 |
Mindy K Ross1, Alexander P Demos1, John Zulueta1, Andrea Piscitello1, Scott A Langenecker1, Melvin McInnis2, Olusola Ajilore1, Peter C Nelson1, Kelly A Ryan2, Alex Leow1.
Abstract
OBJECTIVE: The increase in smartphone usage has enabled the possibility of more accessible ways to conduct neuropsychological evaluations. The objective of this study was to determine the feasibility of using smartphone typing dynamics with mood scores to supplement cognitive assessment through trail making tests.Entities:
Keywords: bipolar disorder; cognition; mHealth; trail making tests; typing dynamics
Mesh:
Year: 2021 PMID: 34612605 PMCID: PMC8613429 DOI: 10.1002/brb3.2363
Source DB: PubMed Journal: Brain Behav Impact factor: 2.708
Descriptive statistics of participants in the study
| Control | Bipolar Disorder |
| |
|---|---|---|---|
|
| 8 | 11 | |
| Age (mean (SD)) | 46.12 (10.72) | 47.09 (10.57) | .847 |
| # dTMT‐Bs (mean (SD)) | 32.00 (16.05) | 30.64 (17.11) | .862 |
| HDRS‐17 (mean SD)) | 1.02 (1.49) | 12.68 (7.80) | .001 |
| YMRS | – | 6.00 (3.80) | – |
| Gender (% Male) | 3 (37.5) | 3 (27.3) | 1.000 |
Abbreviations: dTMT‐B: digital trail making test part B; HDRS‐17: Hamilton Depression Rating Scale 17‐item; YMRS: Young Mania Rating Scale; SD: standard deviation.
aYMRS is not rated in nonbipolar individuals.
FIGURE 1An example digital trail making test part B layout (one out of a total of 12 variations) deployed in this study
FIGURE 2Schematic outlining how keypresses were assigned to each digital trail making test part B (dTMT‐B) to account for missing data
Intraclass correlations (ICC) between the first and last pTMT‐Bs and dTMT‐Bs
| TMT‐B | ICC | Confidence interval |
|---|---|---|
| Cross modality | ||
| First pTMT‐B and First dTMT‐B | 0.74 | 0.32‐0.9 |
| Last pTMT‐B and Last dTMT‐B | 0.14 | ‐1.38‐0.69 |
| Within modality | ||
| First and Last pTMT‐B | 0.72 | 0.36‐0.89 |
| First and Last dTMT‐B | 0.68 | 0.29‐0.87 |
Abbreviations: TMT‐B: trail making test part B; dTMT‐B: digital trail making test part B; pTMT‐B: pencil‐and‐paper trail making test part B.
Model fits and significance of successive fits for the hierarchical models for all participants
| Deviance | Chi square (change in degree of freedom) |
| |
|---|---|---|---|
| Model 1 | 92.63 | ||
| Model 2 | 76.61 | 16.02 (3) | .001 |
| Model 3 | 47.05 | 29.57 (2) | < .001 |
Note:
Model 1: Age + log(# wrong moves) + Time of day administered + log(Day from start of each period) + Study period + log(Day from start of each period) : Study period.
Model 2: Model 1 + Diagnosis + HDRS‐17 (grand mean centered) + HDRS‐17 (subject centered).
Model 3: Model 2 + Median typing speed (grand mean centered) + Median typing speed (subject centered).
HDRS‐17: Hamilton Depression Rating Scale 17‐item; df: degrees of freedom.
Summary of hierarchical longitudinal models for all participants showing the estimates and p‐values for the predictors of digital trail making test part B time
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
| Predictors | Estimates |
| Estimates |
| Estimates |
|
| Intercept | 2.909 |
| 2.914 |
| 2.898 |
|
| Age | 0.113 |
| 0.095 | 0.054 | 0.008 | .784 |
| log(# wrong moves) | 0.222 |
| 0.221 |
| 0.220 |
|
| Time of day administered | 0.015 | .146 | 0.016 | 0.111 | 0.013 | .186 |
| log(Day from start of each period) | −0.077 |
| −0.076 |
| −0.069 |
|
| Study period | −0.055 |
| −0.049 |
| −0.039 |
|
| log(Day from start of each period) : Study period | 0.032 | .084 | 0.042 |
| 0.041 |
|
| Diagnosis | −0.036 | 0.604 | −0.180 |
| ||
| HDRS‐17 score (grand mean centered) | 0.109 | 0.127 | 0.189 |
| ||
| HDRS‐17 score (subject centered) | 0.048 |
| 0.038 |
| ||
| Median typing speed (grand mean centered) | 0.189 |
| ||||
| Median typing speed (subject centered) | 0.032 |
| ||||
| Random effects (variance) | ||||||
| Residual | 0.060 | .058 | 0.058 | |||
| Intercept | Subject | 0.049 | .039 | 0.010 | |||
| Day since start of period | Subject | 0.001 | 7.32e−10 | 0.0003 | |||
| Study period | Subject | 0.001 | .003 | 0.002 | |||
| Days since * Study period | Subject | 0.001 | .003 | 0.002 | |||
| Model fit | ||||||
| Marginal | 0.389 / 0.663 | .461 / .679 | 0.624 / 0.682 | |||
| log‐Likelihood | −46.317 | −38.307 | −23.523 | |||
HDRS‐17: Hamilton Depression Rating Scale 17‐item.
The bold values highlighted the p‐values that were significant.
FIGURE 3Digital trail making test part B (dTMT‐B) time as a function of practice in days since the start of the study period generated by Model 3 with ribbons showing the 95th confidence interval
FIGURE 4Digital trail making test part B (dTMT‐B) time as a function of grand mean centered (a) and subject centered (b) Hamilton Depression Rating Scale 17‐item (HDRS‐17) score generated by Model 3 with ribbons showing the 95th confidence interval
FIGURE 5Digital trail making test part B (dTMT‐B) time as a function of grand mean centered (a) and subject centered (b) typing speed generated by Model 3 with ribbons showing the 95th confidence interval