Literature DB >> 3460063

Exogenous glutathione protects intestinal epithelial cells from oxidative injury.

L H Lash, T M Hagen, D P Jones.   

Abstract

Exogenous GSH provided rat small-intestinal epithelial cells with significant protection against injury induced by t-butyl hydroperoxide or menadione. This protection was found to be dependent upon uptake of intact GSH. Uptake of GSH occurred by a Na+-dependent electrogenic system found in the basolateral membrane. Thus, rat small-intestinal epithelial cells can utilize plasma GSH to support intracellular detoxication systems that function in protection against chemically induced injury.

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Year:  1986        PMID： 3460063      PMCID： PMC323797          DOI： 10.1073/pnas.83.13.4641

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

1.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

2.  The inhibition of gamma-glutamyl transpeptidase and glutathione metabolism of isolated rat kidney cells by L-(alpha S, 5S)-alpha-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).

Authors:  D J Reed; W W Ellis; R A Meck
Journal:  Biochem Biophys Res Commun       Date:  1980-06-30       Impact factor: 3.575

3.  A simple and fast method for the isolation of basolateral plasma membranes from rat small-intestinal epithelial cells.

Authors:  V Scalera; C Storelli; C Storelli-Joss; W Haase; H Murer
Journal:  Biochem J       Date:  1980-01-15       Impact factor: 3.857

4.  Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes.

Authors:  J R Babson; N S Abell; D J Reed
Journal:  Biochem Pharmacol       Date:  1981-08-15       Impact factor: 5.858

5.  Physiological significance of glutathione S-transferases.

Authors:  N Kaplowitz
Journal:  Am J Physiol       Date:  1980-12

6.  High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides.

Authors:  D J Reed; J R Babson; P W Beatty; A E Brodie; W W Ellis; D W Potter
Journal:  Anal Biochem       Date:  1980-07-15       Impact factor: 3.365

7.  Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

Authors:  O W Griffith; A Meister
Journal:  J Biol Chem       Date:  1979-08-25       Impact factor: 5.157

8.  Xenobiotic metabolism by isolated rat small intestinal cells.

Authors:  R Grafström; P Moldéus; B Andersson; S Orrenius
Journal:  Med Biol       Date:  1979-10

9.  Distribution of oxidized and reduced forms of glutathione and cysteine in rat plasma.

Authors:  L H Lash; D P Jones
Journal:  Arch Biochem Biophys       Date:  1985-08-01       Impact factor: 4.013

10.  Superoxide radicals in feline intestinal ischemia.

Authors:  D N Granger; G Rutili; J M McCord
Journal:  Gastroenterology       Date:  1981-07       Impact factor: 22.682
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  28 in total

Review 1.  Redox biology of the intestine.

Authors:  Magdalena L Circu; Tak Yee Aw
Journal:  Free Radic Res       Date:  2011-09-05

Review 2.  Human colonocyte detoxification.

Authors:  W E Roediger; W Babidge
Journal:  Gut       Date:  1997-12       Impact factor: 23.059

3.  Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats.

Authors:  Xian Fan; Pratibha C Joshi; Michael Koval; David M Guidot
Journal:  Alcohol Clin Exp Res       Date:  2011-05-13       Impact factor: 3.455

4.  Gamma-glutamyl transpeptidase, a glutathionase, is present in some cell culture grade bovine sera.

Authors:  M H Hanigan; J E Brown; W A Ricketts
Journal:  In Vitro Cell Dev Biol Anim       Date:  1993-11       Impact factor: 2.416

5.  Chronic exposure to subtoxic levels of peroxidized lipids suppresses mucosal cell turnover in rat small intestine and reversal by glutathione.

Authors:  Seiji Tsunada; Ryuichi Iwakiri; Takahiro Noda; Kazuma Fujimoto; John Fuseler; Carol A Rhoads; Tak Yee Aw
Journal:  Dig Dis Sci       Date:  2003-01       Impact factor: 3.199

6.  Glutathione-mediated detoxification of halobenzoquinone drinking water disinfection byproducts in T24 cells.

Authors:  Jinhua Li; Wei Wang; Hongquan Zhang; X Chris Le; Xing-Fang Li
Journal:  Toxicol Sci       Date:  2014-05-08       Impact factor: 4.849

7.  The effects of glutamine-enriched total parenteral nutrition on tumor growth and host tissues.

Authors:  T R Austgen; P S Dudrick; H Sitren; K I Bland; E Copeland; W W Souba
Journal:  Ann Surg       Date:  1992-02       Impact factor: 12.969

8.  Glutathione redox cycle is an important defense system of endothelial cells against chronic hyperoxia.

Authors:  N Suttorp; S Kästle; H Neuhof
Journal:  Lung       Date:  1991       Impact factor: 2.584

9.  Effects of ischemia and reperfusion on protein synthesis in livers with different glutathione levels.

Authors:  G Nordström; A Säljö; S J Li; P O Hasselgren
Journal:  Ann Surg       Date:  1990-01       Impact factor: 12.969

10.  Intestinal barrier function in response to abundant or depleted mucosal glutathione in Salmonella-infected rats.

Authors:  Marleen T J van Ampting; Arjan J Schonewille; Carolien Vink; Robert Jan M Brummer; Roelof van der Meer; Ingeborg M J Bovee-Oudenhoven
Journal:  BMC Physiol       Date:  2009-04-17
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