Numerical study of the effect of LVAD inflow cannula positioning on thrombosis risk.

Left ventricular assist devices (LVADs) have been increasingly used as a therapy for patients with end-stage heart failure. However, a growing number of clinical observations have shown that LVADs are associated with thromboembolic events, which are potentially related to the changes in intraventricular flow. Particularly, the flow fields around the inflow cannula (IC) of the LVAD. In this study, a fluid structure interaction (FSI) simulation was conducted to evaluate the hemodynamics of a patient specific left ventricle (LV) with varying LVAD IC orientations. The LV model was obtained from computed tomography scans and modeled to have contraction and relaxation during cardiac cycles following available experimental data of LV volume changes. The LV of the patient was assumed to have an end systolic volume of 223.7 mL and a stroke volume of 46.4 mL. Four different IC positions were considered: towards the (1) septum; (2) aortic valve (AV); (3) mitral valve (MV) and (4) inferior wall (IW). The potential thrombus growth around the IC was assumed to be caused by blood stagnation regions with low velocity (<5 mm/s) and low shear rate (<60/s) flow. Mean velocity magnitudes and low blood velocity regions around the IC were numerically obtained. To quantitatively compare the thrombosis risks of the four simulation cases, the time-averaged volumes of the low-velocity regions and the low shear rate regions were calculated. The intraventricular volumes of low velocity zones based on IC orientation are 1.42 mL toward the septum, 1.14 mL toward the AV, 0.93 mL toward the MV, and 1.24 mL toward the IW. The intraventricular volumes of low shear regions based on IC orientation are 11.54 mL toward the septum, 11.15 mL toward the AV, 9.24 mL toward the MV, and 10.7 mL toward the IW. IC orientation toward the MV results in lower volumetric regions of low flow and low shear within the ventricle, which consequently may lead to a reduced risk of thrombus formation.