Ruize Qu1, Yanpeng Ma1, Liyuan Tao2, Xiaoyuan Bao3, Xin Zhou1, Bingyan Wang1, Fei Li1, Siyi Lu1, Lin Tuo4, Siyan Zhan2, Zhipeng Zhang1, Wei Fu1. 1. Department of General Surgery, Peking University Third Hospital, Beijing 100191, China. 2. Clinical Epidemiology Research Center, Peking University Third Hospital, Beijing 100191, China. 3. Medical Information Center, Peking University Health Science Center, Beijing 100191, China. 4. Department of Hospital Management, Peking University Health Science Center, Beijing 100191, China.
Abstract
OBJECTIVE: The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer. However, for Chinese patients, there is limited information on the proportion of cases at each site and the related features. In this study, we explored the location, distribution and other features of colorectal cancers at each anatomic site in Chinese patients. METHODS: We conducted a hospital-based study using hospitalization summary reports from 10 Peking University-affiliated hospitals from 2014 to 2018; the reports covered a total of 2,097,347 hospitalizations. Incident cases were chosen as the study population, and their epidemiological features were further analyzed. RESULTS: A total of 20,739 colorectal cancer patients were identified. Rectum was the most common location (48.3%) of the cancer, whereas the proportions of patients with distal and proximal colon cancer were 24.5% and 18.6%, respectively. Patients with rectal cancer were predominantly male and were the youngest for all anatomical sites (each P<0.001). The highest proportion of emergency admissions, the longest hospital stays and the highest hospitalization costs were found in patients with proximal colon cancer (each P<0.001). The proximal colon cancer subgroup included the highest proportions of patients with medical histories of cholecystectomy, cholecystolithiasis and/or gallbladder polyps and appendectomy (P=0.009, P<0.001 and P<0.001, respectively). The distal colon cancer subgroup included the highest proportions of patients with medical histories of diabetes and hypertension (P<0.001, respectively). CONCLUSIONS: The patterns of colorectal cancer observed in this study differ from those reported for Western patients and show a significantly higher proportion of patients with rectal cancer. Different epidemiological features were also found based on anatomic sites. Further studies based on tumor location should be conducted to facilitate more accurate screening and treatment.
OBJECTIVE: The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer. However, for Chinese patients, there is limited information on the proportion of cases at each site and the related features. In this study, we explored the location, distribution and other features of colorectal cancers at each anatomic site in Chinese patients. METHODS: We conducted a hospital-based study using hospitalization summary reports from 10 Peking University-affiliated hospitals from 2014 to 2018; the reports covered a total of 2,097,347 hospitalizations. Incident cases were chosen as the study population, and their epidemiological features were further analyzed. RESULTS: A total of 20,739 colorectal cancer patients were identified. Rectum was the most common location (48.3%) of the cancer, whereas the proportions of patients with distal and proximal colon cancer were 24.5% and 18.6%, respectively. Patients with rectal cancer were predominantly male and were the youngest for all anatomical sites (each P<0.001). The highest proportion of emergency admissions, the longest hospital stays and the highest hospitalization costs were found in patients with proximal colon cancer (each P<0.001). The proximal colon cancer subgroup included the highest proportions of patients with medical histories of cholecystectomy, cholecystolithiasis and/or gallbladder polyps and appendectomy (P=0.009, P<0.001 and P<0.001, respectively). The distal colon cancer subgroup included the highest proportions of patients with medical histories of diabetes and hypertension (P<0.001, respectively). CONCLUSIONS: The patterns of colorectal cancer observed in this study differ from those reported for Western patients and show a significantly higher proportion of patients with rectal cancer. Different epidemiological features were also found based on anatomic sites. Further studies based on tumor location should be conducted to facilitate more accurate screening and treatment.
Authors: Janet S de Moor; Robin A Cohen; Jean A Shapiro; Marion R Nadel; Susan A Sabatino; K Robin Yabroff; Stacey Fedewa; Richard Lee; V Paul Doria-Rose; Cheryl Altice; Carrie N Klabunde Journal: Prev Med Date: 2018-05-03 Impact factor: 4.018
Authors: Rafael Cardoso; Feng Guo; Thomas Heisser; Monika Hackl; Petra Ihle; Harlinde De Schutter; Nancy Van Damme; Zdravka Valerianova; Trajan Atanasov; Ondřej Májek; Jan Mužík; Mef Christina Nilbert; Anne Julie Tybjerg; Kaire Innos; Margit Mägi; Nea Malila; Anne-Marie Bouvier; Véronique Bouvier; Guy Launoy; Anne-Sophie Woronoff; Mélanie Cariou; Michel Robaszkiewicz; Patricia Delafosse; Florence Poncet; Alexander Katalinic; Paul M Walsh; Carlo Senore; Stefano Rosso; Ieva Vincerževskienė; Valery E P P Lemmens; Marloes A G Elferink; Tom Børge Johannesen; Hartwig Kørner; Frank Pfeffer; Maria José Bento; Jessica Rodrigues; Filipa Alves da Costa; Ana Miranda; Vesna Zadnik; Tina Žagar; Arantza Lopez de Munain Marques; Rafael Marcos-Gragera; Montse Puigdemont; Jaume Galceran; Marià Carulla; María-Dolores Chirlaque; Monica Ballesta; Kristina Sundquist; Jan Sundquist; Marco Weber; Andrea Jordan; Christian Herrmann; Mohsen Mousavi; Anton Ryzhov; Michael Hoffmeister; Hermann Brenner Journal: Lancet Oncol Date: 2021-05-25 Impact factor: 54.433