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Literature DB >> 34582060

AMPK CA(R)Sts a new light on amino acid sensing.

Abstract

AMP-activated protein kinase (AMPK) is recognized as a critical regulator of cellular energy metabolism impacted by AMP/ATP and ADP/ATP ratios, or glucose- and fatty acid-derived metabolites. However, its ability to sense alterations in amino acid levels is poorly understood. Recent work by Yuan et al (2021) identifies a novel mechanism of AMPK regulation responsive to changes in availability of the sulfur-containing amino acid cysteine.

Entities: Chemical

Mesh：

Substances：

Year: 2021 PMID： 34582060 PMCID： PMC8561628 DOI： 10.15252/embj.2021109575

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

8 in total

Review 1. Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping.

Authors: Sunghoon Kim; Sungyong You; Daehee Hwang
Journal: Nat Rev Cancer Date: 2011-09-23 Impact factor: 60.716

Review 2. Nutrient-sensing mechanisms and pathways.

Authors: Alejo Efeyan; William C Comb; David M Sabatini
Journal: Nature Date: 2015-01-15 Impact factor: 49.962

3. Cysteine depletion induces pancreatic tumor ferroptosis in mice.

Authors: Michael A Badgley; Daniel M Kremer; H Carlo Maurer; Kathleen E DelGiorno; Ho-Joon Lee; Vinee Purohit; Irina R Sagalovskiy; Alice Ma; Jonathan Kapilian; Christina E M Firl; Amanda R Decker; Steve A Sastra; Carmine F Palermo; Leonardo R Andrade; Peter Sajjakulnukit; Li Zhang; Zachary P Tolstyka; Tal Hirschhorn; Candice Lamb; Tong Liu; Wei Gu; E Scott Seeley; Everett Stone; George Georgiou; Uri Manor; Alina Iuga; Geoffrey M Wahl; Brent R Stockwell; Costas A Lyssiotis; Kenneth P Olive
Journal: Science Date: 2020-04-03 Impact factor: 47.728

1 in total

1. AMPK CA(R)Sts a new light on amino acid sensing.

Authors: Kristin K Brown
Journal: EMBO J Date: 2021-09-28 Impact factor: 11.598

1 in total

AMPK CA(R)Sts a new light on amino acid sensing.

Review 1. Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping.

Review 2. Nutrient-sensing mechanisms and pathways.

3. Cysteine depletion induces pancreatic tumor ferroptosis in mice.

4. Sestrin2 is a leucine sensor for the mTORC1 pathway.

5. Understanding the role of cysteine in ferroptosis: progress & paradoxes.

6. AMPK CA(R)Sts a new light on amino acid sensing.

7. CARS senses cysteine deprivation to activate AMPK for cell survival.

Review 8. The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival.

1. AMPK CA(R)Sts a new light on amino acid sensing.