Literature DB >> 34565562

Ode to Salt: Commentary on "Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity".

Theodora M Mauro1.   

Abstract

"Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity" (Maifeld et al., 2021) showed that skin sodium ion (Na+) is increased in patients with a PASI > 5. Na+ concentration as well as its content were increased in these patients, supporting the proposed mechanism that increased Na+ concentrations enhance IL-17 expression from CD4+ cells. These data initially were generated using a noninvasive technique, sodium (23Na) magnetic resonance imaging, and then were verified using 23Na spectroscopy and atomic absorption spectrometry in ashed-skin biopsies in humans and also using mouse models of psoriasis. These findings suggest a novel pathologic mechanism for psoriasis development and target for treatment.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2021        PMID： 34565562      PMCID： PMC8740904          DOI： 10.1016/j.jid.2021.08.401

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   7.590


  22 in total

1.  Skin Sodium Concentration Correlates with Left Ventricular Hypertrophy in CKD.

Authors:  Markus P Schneider; Ulrike Raff; Christoph Kopp; Johannes B Scheppach; Sebastian Toncar; Christoph Wanner; Georg Schlieper; Turgay Saritas; Jürgen Floege; Matthias Schmid; Anna Birukov; Anke Dahlmann; Peter Linz; Rolf Janka; Michael Uder; Roland E Schmieder; Jens M Titze; Kai-Uwe Eckardt
Journal:  J Am Soc Nephrol       Date:  2017-02-02       Impact factor: 10.121

2.  Ion channels are linked to differentiation in keratinocytes.

Authors:  T M Mauro; R R Isseroff; R Lasarow; P A Pappone
Journal:  J Membr Biol       Date:  1993-03       Impact factor: 1.843

3.  The ENaC channel is required for normal epidermal differentiation.

Authors:  T Mauro; M Guitard; M Behne; Y Oda; D Crumrine; L Komuves; U Rassner; P M Elias; E Hummler
Journal:  J Invest Dermatol       Date:  2002-04       Impact factor: 8.551

4.  Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment.

Authors:  Julia Matthias; Julia Maul; Rebecca Noster; Hanna Meinl; Ying-Yin Chao; Heiko Gerstenberg; Florian Jeschke; Gilles Gasparoni; Anna Welle; Jörn Walter; Karl Nordström; Klaus Eberhardt; Dennis Renisch; Sainitin Donakonda; Percy Knolle; Dominik Soll; Stephan Grabbe; Natalie Garzorz-Stark; Kilian Eyerich; Tilo Biedermann; Dirk Baumjohann; Christina E Zielinski
Journal:  Sci Transl Med       Date:  2019-02-20       Impact factor: 17.956

5.  Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected by 23Na magnetic resonance imaging.

Authors:  Christoph Kopp; Peter Linz; Carolin Maier; Peter Wabel; Matthias Hammon; Armin M Nagel; Daniela Rosenhauer; Stephan Horn; Michael Uder; Friedrich C Luft; Jens Titze; Anke Dahlmann
Journal:  Kidney Int       Date:  2018-02-15       Impact factor: 10.612

6.  Epithelial sodium channel in human epidermal keratinocytes: expression of its subunits and relation to sodium transport and differentiation.

Authors:  M Brouard; M Casado; S Djelidi; Y Barrandon; N Farman
Journal:  J Cell Sci       Date:  1999-10       Impact factor: 5.285

Review 7.  Skin Sodium and Hypertension: a Paradigm Shift?

Authors:  Viknesh Selvarajah; Kathleen Connolly; Carmel McEniery; Ian Wilkinson
Journal:  Curr Hypertens Rep       Date:  2018-09-13       Impact factor: 5.369

Review 8.  Physiological mechanisms determining eccrine sweat composition.

Authors:  Lindsay B Baker; Anthony S Wolfe
Journal:  Eur J Appl Physiol       Date:  2020-03-02       Impact factor: 3.078

9.  Magnetic resonance-determined sodium removal from tissue stores in hemodialysis patients.

Authors:  Anke Dahlmann; Kathrin Dörfelt; Florian Eicher; Peter Linz; Christoph Kopp; Irina Mössinger; Stephan Horn; Beatrix Büschges-Seraphin; Peter Wabel; Matthias Hammon; Alexander Cavallaro; Kai-Uwe Eckardt; Peter Kotanko; Nathan W Levin; Bernd Johannes; Michael Uder; Friedrich C Luft; Dominik N Müller; Jens M Titze
Journal:  Kidney Int       Date:  2014-08-06       Impact factor: 10.612
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  1 in total

Review 1.  Oxidative Stress Induced by High Salt Diet-Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris.

Authors:  Ivana Krajina; Ana Stupin; Marija Šola; Martina Mihalj
Journal:  Antioxidants (Basel)       Date:  2022-06-27
  1 in total

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