| Literature DB >> 3455845 |
I Jack, R Seshadri, M Garson, P Michael, D Callen, H Zola, A Morley.
Abstract
A cell line (RCH-ACV) was established from a bone marrow sample of a child with acute lymphoblastic leukemia (ALL). The cell line lacked Epstein-Barr virus nuclear antigen and exhibited a recently described nonrandom chromosome translocation, 1;19, thought to be associated with pre-B-ALL and poor prognosis. Banding studies confirm that the breakpoint of chromosome #19 occurs at p13.3. Cell surface marker analysis using a panel of monoclonal antibodies revealed markers consistent with common ALL phenotype. Although the cells did not show cytoplasmic immunoglobulin, studies of the immunoglobulin gene rearrangement confirmed the pre-B phenotype. This cell line could be of great value to studies of the role of the specific translocation 1;19 in the etiology of pre-B-ALL.Entities:
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Year: 1986 PMID： 3455845 DOI： 10.1016/0165-4608(86)90055-5
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608