Literature DB >> 34555162

Sex Differences in Recovery Across Multiple Domains Among Older Adults With Hip Fracture.

Denise L Orwig1, Danielle S Abraham2, Marc C Hochberg1, Ann Gruber-Baldini1, Jack M Guralnik1, Anne R Cappola2, Justine Golden1, Gregory E Hicks3, Ram R Miller4, Barbara Resnick5, Michelle Shardell1, Robert S Sterling6, Rashmita Bajracharya1, Jay Magaziner1.   

Abstract

BACKGROUND: Hip fractures are a public health problem among older adults, but most research on recovery after hip fracture has been limited to females. With growing numbers of hip fractures among males, it is important to determine how recovery outcomes may differ between the sexes.
METHODS: 168 males and 171 females were enrolled within 15 days of hospitalization with follow-up visits at 2, 6, and 12 months postadmission to assess changes in disability, physical performance, cognition, depressive symptoms, body composition, and strength, and all-cause mortality. Generalized estimating equations examined whether males and females followed identical outcome recovery assessed by the change in each outcome.
RESULTS: The mean age at fracture was similar for males (80.4) and females (81.4), and males had more comorbidities (2.5 vs 1.6) than females. Males were significantly more likely to die over 12 months (hazard ratio 2.89, 95% confidence interval: 1.56-5.34). Changes in outcomes were significantly different between males and females for disability, gait speed, and depressive symptoms (p < .05). Both sexes improved from baseline to 6 months for these measures, but only males continued to improve between 6 and 12 months. There were baseline differences for most body composition measures and strength; however, there were no significant differences in change by sex.
CONCLUSIONS: Findings confirm that males have higher mortality but suggest that male survivors have continued functional recovery over the 12 months compared to females. Research is needed to determine the underlying causes of these sex differences for developing future prognostic information and rehabilitative interventions.
© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Body composition; Function; Gait speed; Mortality

Mesh:

Year:  2022        PMID: 34555162      PMCID: PMC9255694          DOI: 10.1093/gerona/glab271

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN: 1079-5006            Impact factor:   6.591


  52 in total

1.  Predictors of functional recovery one year following hospital discharge for hip fracture: a prospective study.

Authors:  J Magaziner; E M Simonsick; T M Kashner; J R Hebel; J E Kenzora
Journal:  J Gerontol       Date:  1990-05

2.  Physical performance trajectories and mortality among nursing home residents: results of the SENIOR cohort.

Authors:  Alexia Charles; Johann Detilleux; Fanny Buckinx; Jean-Yves Reginster; Bastien Gruslin; Olivier Bruyère
Journal:  Age Ageing       Date:  2020-08-24       Impact factor: 10.668

3.  Semiparametric regression models for repeated measures of mortal cohorts with non-monotone missing outcomes and time-dependent covariates.

Authors:  Michelle Shardell; Gregory E Hicks; Ram R Miller; Jay Magaziner
Journal:  Stat Med       Date:  2010-09-30       Impact factor: 2.373

4.  The mobility gap between older men and women: the embodiment of gender.

Authors:  M V Zunzunegui; B E Alvarado; R Guerra; J F Gómez; A Ylli; J M Guralnik
Journal:  Arch Gerontol Geriatr       Date:  2015-06-17       Impact factor: 3.250

5.  Physical performance measures in the clinical setting.

Authors:  Stephanie Studenski; Subashan Perera; Dennis Wallace; Julie M Chandler; Pamela W Duncan; Earl Rooney; Michael Fox; Jack M Guralnik
Journal:  J Am Geriatr Soc       Date:  2003-03       Impact factor: 5.562

6.  Body composition explains sex differential in physical performance among older adults.

Authors:  Lisa A Tseng; Matthew J Delmonico; Marjolein Visser; Robert M Boudreau; Bret H Goodpaster; Ann V Schwartz; Eleanor M Simonsick; Suzanne Satterfield; Tamara Harris; Anne B Newman
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2013-05-16       Impact factor: 6.053

7.  The association of race, gender, and comorbidity with mortality and function after hip fracture.

Authors:  Joan D Penrod; Ann Litke; William G Hawkes; Jay Magaziner; John T Doucette; Kenneth J Koval; Stacey B Silberzweig; Kenneth A Egol; Albert L Siu
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2008-08       Impact factor: 6.053

8.  Differences in the trajectory of bone mineral density change measured at the total hip and femoral neck between men and women following hip fracture.

Authors:  Alan M Rathbun; Michelle Shardell; Denise Orwig; J Richard Hebel; Gregory E Hicks; Thomas Beck; Marc C Hochberg; Jay Magaziner
Journal:  Arch Osteoporos       Date:  2016-02-04       Impact factor: 2.617

9.  Influence of comorbidities on functional outcomes in patients with surgically treated fragility hip fractures: a retrospective cohort study.

Authors:  Soo Hoon Yoon; Bo Ryun Kim; Sang Yoon Lee; Jaewon Beom; Jun Hwan Choi; Jae-Young Lim
Journal:  BMC Geriatr       Date:  2021-04-28       Impact factor: 3.921

10.  Walking recovery after a hip fracture: a prospective follow-up study among community-dwelling over 60-year old men and women.

Authors:  Anu Salpakoski; Timo Törmäkangas; Johanna Edgren; Sanna Sihvonen; Mika Pekkonen; Ari Heinonen; Maija Pesola; Mauri Kallinen; Taina Rantanen; Sarianna Sipilä
Journal:  Biomed Res Int       Date:  2014-01-06       Impact factor: 3.411

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  1 in total

1.  Prognostic Factors for Mortality, Activity of Daily Living, and Quality of Life in Taiwanese Older Patients within 1 Year Following Hip Fracture Surgery.

Authors:  Ming-Hsiu Chiang; Yu-Yun Huang; Yi-Jie Kuo; Shu-Wei Huang; Yeu-Chai Jang; Fu-Ling Chu; Yu-Pin Chen
Journal:  J Pers Med       Date:  2022-01-13
  1 in total

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