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Literature DB >> 34550529

ImmunoPET: harnessing antibodies for imaging immune cells.

Anna M Wu^1,2, Neeta Pandit-Taskar^3,4,5.

Abstract

Dramatic, but uneven, progress in the development of immunotherapies for cancer has created a need for better diagnostic technologies including innovative non-invasive imaging approaches. This review discusses challenges and opportunities for molecular imaging in immuno-oncology and focuses on the unique role that antibodies can fill. ImmunoPET has been implemented for detection of immune cell subsets, activation and inhibitory biomarkers, tracking adoptively transferred cellular therapeutics, and many additional applications in preclinical models. Parallel progress in radionuclide availability and infrastructure supporting biopharmaceutical manufacturing has accelerated clinical translation. ImmunoPET is poised to provide key information on prognosis, patient selection, and monitoring immune responses to therapy in cancer and beyond.

Entities: Chemical

Keywords: Antibodies; CD8; Cancer; ImmunoPET; Immunotherapy; T cells

Mesh：

Substances：
Antibodies
Radioisotopes

Year: 2021 PMID： 34550529 DOI： 10.1007/s11307-021-01652-7

Source DB: PubMed Journal: Mol Imaging Biol ISSN： 1536-1632 Impact factor: 3.488

96 in total

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Authors: Efthymia Papalexi; Rahul Satija
Journal: Nat Rev Immunol Date: 2017-08-07 Impact factor: 53.106

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Journal: Mol Imaging Biol Date: 2011-10 Impact factor: 3.488

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8. [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.

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4 in total

Review 1. Cardiac imaging techniques for the assessment of immune checkpoint inhibitor-induced cardiotoxicity and their potential clinical applications.

Authors: Yi Li; Pei-Jun Liu; Zhuo-Li Zhang; Yi-Ning Wang
Journal: Am J Cancer Res Date: 2022-08-15 Impact factor: 5.942