Literature DB >> 34546528

The Prevailing Role of Topoisomerase 2 Beta and its Associated Genes in Neurons.

Pankaj Singh Dholaniya1.   

Abstract

Topoisomerase 2 beta (TOP2β) is an enzyme that alters the topological states of DNA by making a transient double-strand break during the transcription process. The direct interaction of TOP2β with DNA strand results in transcriptional regulation of certain genes and some studies have suggested that a particular set of genes are regulated by TOP2β, which have a prominent role in various stages of neuron from development to degeneration. In this review, we discuss the role of TOP2β in various phases of the neuron's life. Based on the existing reports, we have compiled the list of genes, which are directly regulated by the enzyme, from different studies and performed their functional classification. We discuss the role of these genes in neurogenesis, neuron migration, fate determination, differentiation and maturation, generation of neural circuits, and senescence.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Degeneration; Development; Neuron; Senescence; Top2b; Topoisomerases

Mesh：

Substances：

Year:  2021        PMID： 34546528     DOI： 10.1007/s12035-021-02561-0

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  138 in total

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Journal:  Nat Rev Mol Cell Biol       Date:  2002-06       Impact factor: 94.444

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Journal:  Q Rev Biophys       Date:  2008-02       Impact factor: 5.318

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5.  Is DNA topoisomerase II beta a nucleolar protein?

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Journal:  J Cell Biochem       Date:  1996-11-01       Impact factor: 4.429

6.  Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state.

Authors:  Vijay K Tiwari; Lukas Burger; Vassiliki Nikoletopoulou; Ruben Deogracias; Sudhir Thakurela; Christiane Wirbelauer; Johannes Kaut; Remi Terranova; Leslie Hoerner; Christian Mielke; Fritz Boege; Rabih Murr; Antoine H F M Peters; Yves-Alain Barde; Dirk Schübeler
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-02       Impact factor: 11.205

7.  Role of topoisomerase IIbeta in the expression of developmentally regulated genes.

Authors:  Yi Lisa Lyu; Chao-Po Lin; Anna M Azarova; Li Cai; James C Wang; Leroy F Liu
Journal:  Mol Cell Biol       Date:  2006-08-21       Impact factor: 4.272

8.  Hundreds of variants clustered in genomic loci and biological pathways affect human height.

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Journal:  Nature       Date:  2010-09-29       Impact factor: 49.962

9.  Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.

Authors:  Morten O Christensen; Morten K Larsen; Hans Ullrich Barthelmes; Robert Hock; Claus L Andersen; Eigil Kjeldsen; Birgitta R Knudsen; Ole Westergaard; Fritz Boege; Christian Mielke
Journal:  J Cell Biol       Date:  2002-04-01       Impact factor: 10.539

10.  Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain.

Authors:  Akihisa Onoda; Osamu Hosoya; Kuniaki Sano; Kazuko Kiyama; Hiroshi Kimura; Shinji Kawano; Ryohei Furuta; Mary Miyaji; Ken Tsutsui; Kimiko M Tsutsui
Journal:  Nucleic Acids Res       Date:  2014-07-17       Impact factor: 16.971
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