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Literature DB >> 34542920

A killer metamorphosis: catching BAK in action at the membrane.

Adedolapo M Ojoawo^1,2, Tudor Moldoveanu^1,2.

Abstract

Permeabilization of the outer mitochondrial membrane initiates apoptotic cell death. B-cell lymphoma 2 (BCL-2) antagonist killer (BAK) and BCL-2-associated X (BAX) mediate mitochondrial poration, but how this process unfolds remains poorly defined. Two studies in this issue investigate the transition of dormant, inactive BAK monomer to a highly dynamic membrane-associated, pore-forming oligomer.

Entities: Chemical

Mesh：

Substances：

Year: 2021 PMID： 34542920 PMCID： PMC8521302 DOI： 10.15252/embj.2021109529

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 14.012

10 in total

1. Structure of detergent-activated BAK dimers derived from the inert monomer.

Authors: Richard W Birkinshaw; Sweta Iyer; Daisy Lio; Cindy S Luo; Jason M Brouwer; Michelle S Miller; Adeline Y Robin; Rachel T Uren; Grant Dewson; Ruth M Kluck; Peter M Colman; Peter E Czabotar
Journal: Mol Cell Date: 2021-03-31 Impact factor: 17.970

2. BAK core dimers bind lipids and can be bridged by them.

Authors: Angus D Cowan; Nicholas A Smith; Jarrod J Sandow; Eugene A Kapp; Yepy H Rustam; James M Murphy; Jason M Brouwer; Jonathan P Bernardini; Michael J Roy; Ahmad Z Wardak; Iris K Tan; Andrew I Webb; Jacqueline M Gulbis; Brian J Smith; Gavin E Reid; Grant Dewson; Peter M Colman; Peter E Czabotar
Journal: Nat Struct Mol Biol Date: 2020-09-14 Impact factor: 15.369

Review 3. Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins.

Authors: Rumani Singh; Anthony Letai; Kristopher Sarosiek
Journal: Nat Rev Mol Cell Biol Date: 2019-03 Impact factor: 94.444

4. A killer metamorphosis: catching BAK in action at the membrane.

Authors: Adedolapo M Ojoawo; Tudor Moldoveanu
Journal: EMBO J Date: 2021-09-20 Impact factor: 14.012

Review 5. BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins.

Authors: Tudor Moldoveanu; Peter E Czabotar
Journal: Cold Spring Harb Perspect Biol Date: 2020-04-01 Impact factor: 10.005

6. An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣membrane.

Authors: Fujiao Lv; Fei Qi; Zhi Zhang; Maorong Wen; Justin Kale; Alessandro Piai; Lingyu Du; Shuqing Wang; Liujuan Zhou; Yaqing Yang; Bin Wu; Zhijun Liu; Juan Del Rosario; Justin Pogmore; James J Chou; David W Andrews; Jialing Lin; Bo OuYang
Journal: EMBO J Date: 2021-06-08 Impact factor: 11.598

7. Dynamic reconfiguration of pro-apoptotic BAK on membranes.

Authors: Jarrod J Sandow; Iris Kl Tan; Alan S Huang; Shashank Masaldan; Jonathan P Bernardini; Ahmad Z Wardak; Richard W Birkinshaw; Robert L Ninnis; Ziyan Liu; Destiny Dalseno; Daisy Lio; Giuseppi Infusini; Peter E Czabotar; Andrew I Webb; Grant Dewson
Journal: EMBO J Date: 2021-09-15 Impact factor: 14.012

1 in total

1. A killer metamorphosis: catching BAK in action at the membrane.