Literature DB >> 34541201

Uptake Assays to Monitor Anthracyclines Entry into Mammalian Cells.

Nicolas Brosseau1, Emil Andreev1, Dindial Ramotar1.   

Abstract

Anthracyclines, such as doxorubicin and daunorubicin, are DNA damaging agents that autofluoresce and can be readily detected in cells. Herein, we developed suitable assays to quantify and localize daunorubicin in mammalian cells. These assays can be exploited to identify components that are involved in the uptake of anthracyclines.
Copyright © 2017 The Authors; exclusive licensee Bio-protocol LLC.

Entities:  

Keywords:  Anthracyclines; Autofluorescent drugs; Epifluorescence microscopy; FACS analysis; Fluoroskan reader; Influx transporters

Year:  2017        PMID： 34541201      PMCID： PMC8413657          DOI： 10.21769/BioProtoc.2555

Source DB:  PubMed          Journal:  Bio Protoc        ISSN： 2331-8325


  13 in total

1.  The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4.

Authors:  Fanfan Zhou; Wen Xu; Mei Hong; Zui Pan; Patrick J Sinko; Jianjie Ma; Guofeng You
Journal:  Mol Pharmacol       Date:  2004-12-02       Impact factor: 4.436

Review 2.  Regulation of organic cation transport.

Authors:  Giuliano Ciarimboli; Eberhard Schlatter
Journal:  Pflugers Arch       Date:  2004-11-16       Impact factor: 3.657

3.  Functional influence of N-glycosylation in OCT2-mediated tetraethylammonium transport.

Authors:  Ryan M Pelis; Wendy M Suhre; Stephen H Wright
Journal:  Am J Physiol Renal Physiol       Date:  2005-12-20

4.  Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein.

Authors:  Chiara Riganti; Elena Gazzano; Giulia Rossana Gulino; Marco Volante; Dario Ghigo; Joanna Kopecka
Journal:  Cancer Lett       Date:  2015-02-11       Impact factor: 8.679

5.  Glycosylation of the OCTN2 carnitine transporter: study of natural mutations identified in patients with primary carnitine deficiency.

Authors:  Cristina Amat di San Filippo; Orly Ardon; Nicola Longo
Journal:  Biochim Biophys Acta       Date:  2010-11-29

Review 6.  Drug resistance mechanisms in acute leukemia.

Authors:  T R Chauncey
Journal:  Curr Opin Oncol       Date:  2001-01       Impact factor: 3.645

Review 7.  A Call for Systematic Research on Solute Carriers.

Authors:  Adrián César-Razquin; Berend Snijder; Tristan Frappier-Brinton; Ruth Isserlin; Gergely Gyimesi; Xiaoyun Bai; Reinhart A Reithmeier; David Hepworth; Matthias A Hediger; Aled M Edwards; Giulio Superti-Furga
Journal:  Cell       Date:  2015-07-30       Impact factor: 41.582

Review 8.  Anthracyclines potentiate anti-tumor immunity: A new opportunity for chemoimmunotherapy.

Authors:  Zhigang Zhang; Xiuyan Yu; Xiuyang Yu; Zhen Wang; Pin Wu; Jian Huang
Journal:  Cancer Lett       Date:  2015-10-11       Impact factor: 8.679

9.  The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.

Authors:  Mustapha Aouida; Richard Poulin; Dindial Ramotar
Journal:  J Biol Chem       Date:  2009-12-25       Impact factor: 5.157

10.  A phosphotyrosine switch regulates organic cation transporters.

Authors:  Jason A Sprowl; Su Sien Ong; Alice A Gibson; Shuiying Hu; Guoqing Du; Wenwei Lin; Lie Li; Shashank Bharill; Rachel A Ness; Adrian Stecula; Steven M Offer; Robert B Diasio; Anne T Nies; Matthias Schwab; Guido Cavaletti; Eberhard Schlatter; Giuliano Ciarimboli; Jan H M Schellens; Ehud Y Isacoff; Andrej Sali; Taosheng Chen; Sharyn D Baker; Alex Sparreboom; Navjotsingh Pabla
Journal:  Nat Commun       Date:  2016-03-16       Impact factor: 14.919
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