| Literature DB >> 26232220 |
Adrián César-Razquin1, Berend Snijder1, Tristan Frappier-Brinton2, Ruth Isserlin3, Gergely Gyimesi4, Xiaoyun Bai5, Reinhart A Reithmeier5, David Hepworth6, Matthias A Hediger7, Aled M Edwards8, Giulio Superti-Furga9.
Abstract
Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of similar stature, SLCs are relatively understudied. The time is right for a systematic attack on SLC structure, specificity, and function, taking into account kinship and expression, as well as the dependencies that arise from the common metabolic space.Entities:
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Year: 2015 PMID： 26232220 DOI： 10.1016/j.cell.2015.07.022
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582