Literature DB >> 34541064

Imaging the Pharynx to Measure the Uptake of Doxorubicin in Caenorhabditis elegans.

Sivathevy Amirthagunabalasingam1, Arturo Papaluca2, Taramatti Harihar1, Dindial Ramotar1.   

Abstract

Caenorhabditis elegans offers an array of advantages to investigate the roles of uptake transporters. Herein, an epifluorescent microscopy approach was developed to monitor the uptake of the autofluorescent anticancer drug, doxorubicin, into the pharynx of C. elegans by organic cation transporters.
Copyright © 2017 The Authors; exclusive licensee Bio-protocol LLC.

Entities:  

Keywords:  Autofluorescent drug; C. elegans; Doxorubicin; Drug uptake; Epifluorescent microscopy; Organic cation uptake transporters; RNAi feeding bacteria

Year:  2017        PMID： 34541064      PMCID： PMC8410275          DOI： 10.21769/BioProtoc.2291

Source DB:  PubMed          Journal:  Bio Protoc        ISSN： 2331-8325


  6 in total

Review 1.  C. elegans in high-throughput drug discovery.

Authors:  Linda P O'Reilly; Cliff J Luke; David H Perlmutter; Gary A Silverman; Stephen C Pak
Journal:  Adv Drug Deliv Rev       Date:  2013-12-12       Impact factor: 15.470

2.  Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter.

Authors:  X Wu; Y J Fei; W Huang; C Chancy; F H Leibach; V Ganapathy
Journal:  Biochim Biophys Acta       Date:  1999-04-14

3.  Knockout of a putative ergothioneine transporter in Caenorhabditis elegans decreases lifespan and increases susceptibility to oxidative damage.

Authors:  I K Cheah; R L S Ong; J Gruber; T S K Yew; L F Ng; C B Chen; B Halliwell
Journal:  Free Radic Res       Date:  2013-10-24

4.  A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

Authors:  Andrew R Burns; Iain M Wallace; Jan Wildenhain; Mike Tyers; Guri Giaever; Gary D Bader; Corey Nislow; Sean R Cutler; Peter J Roy
Journal:  Nat Chem Biol       Date:  2010-05-30       Impact factor: 15.040

Review 5.  A Call for Systematic Research on Solute Carriers.

Authors:  Adrián César-Razquin; Berend Snijder; Tristan Frappier-Brinton; Ruth Isserlin; Gergely Gyimesi; Xiaoyun Bai; Reinhart A Reithmeier; David Hepworth; Matthias A Hediger; Aled M Edwards; Giulio Superti-Furga
Journal:  Cell       Date:  2015-07-30       Impact factor: 41.582

6.  A novel approach using C. elegans DNA damage-induced apoptosis to characterize the dynamics of uptake transporters for therapeutic drug discoveries.

Authors:  Arturo Papaluca; Dindial Ramotar
Journal:  Sci Rep       Date:  2016-10-27       Impact factor: 4.379
  6 in total

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