Juan Mario Solis Paredes1, Otilia Perichart Perera2, Araceli Montoya Estrada3, Enrique Reyes Muñoz3, Salvador Espino Y Sosa4, Veronica Ortega Castillo5, Diana Medina Bastidas6, Maricruz Tolentino Dolores2, Maribel Sanchez Martinez7, Sonia Nava Salazar7, Guadalupe Estrada Gutierrez8. 1. Department of Human Genetics and Genomics, Instituto Nacional de Perinatologia, Mexico City, Mexico. 2. Instituto Nacional de Perinatologia, Nutrition and Bioprogramming Coordination, Mexico City, Mexico. 3. Instituto Nacional de Perinatologia, Coordination of Gynecological and Perinatal Endocrinology, Mexico City, Mexico. 4. Instituto Nacional de Perinatologia, Clinical Research Branch, Mexico City, Mexico. 5. Department of Obstetrics, Instituto Nacional de Perinatologia, Mexico City, Mexico. 6. Instituto Nacional de Perinatologia- Facultad de Quimica-UNAM, Unidad de Investigación en Reproducción Humana, Mexico City, Mexico. 7. Department of Inmunobiochemistry, Instituto Nacional de Perinatologia, Mexico City, Mexico. 8. Research Division, Instituto Nacional de Perinatologia, Mexico City, Mexico.
Abstract
INTRODUCTION AND OBJECTIVE: The weight gained during pregnancy could determine the immediate and future health of the mother-child dyad. Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational diabetes, macrosomia, obesity, and hypertension further in life. Dysregulation of adipokine, AT dysfunction, and an imbalance in the prooxidant-antioxidant systems are critical features in altered AT accumulation. This study was aimed to investigate the association between adipokines and oxidative stress markers in pregnant women and the influence of the GWG on this association. METHODS: Maternal blood samples were obtained in the third trimester of pregnancy (n = 74) and serum adipokines (adiponectin, leptin, and resistin), oxidative damage markers: 8-oxo-2'-deoxyguanosine (8-oxodG), lipohydroperoxides (LOOH), malondialdehyde (MDA), and carbonylated proteins (CP), and glucose a metabolic marker were measured. RESULTS: Women with EGWG had low adiponectin levels than women with adequate weight gain (AWG) or insufficient weight gain (IWG). Multiple linear regression models revealed a positive association between adiponectin and 8-oxodG in women with AWG (B = 1.09, 95% CI: 164-222, p = 0.027) and IWG (B = 0.860, 95% CI: 0.199-1.52, p = 0.013) but not in women with EGWG. In women with EGWG, leptin was positively associated with LOOH (p = 0.018), MDA (p = 0.005), and CP (p = 0.010) oxidative markers. CONCLUSION: Our findings suggest that concurrent mechanisms regulate adipokine production and oxidative stress in pregnant women and that this regulation is influenced by GWG, probably due to an excessive AT accumulation.
INTRODUCTION AND OBJECTIVE: The weight gained during pregnancy could determine the immediate and future health of the mother-child dyad. Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational diabetes, macrosomia, obesity, and hypertension further in life. Dysregulation of adipokine, AT dysfunction, and an imbalance in the prooxidant-antioxidant systems are critical features in altered AT accumulation. This study was aimed to investigate the association between adipokines and oxidative stress markers in pregnant women and the influence of the GWG on this association. METHODS: Maternal blood samples were obtained in the third trimester of pregnancy (n = 74) and serum adipokines (adiponectin, leptin, and resistin), oxidative damage markers: 8-oxo-2'-deoxyguanosine (8-oxodG), lipohydroperoxides (LOOH), malondialdehyde (MDA), and carbonylated proteins (CP), and glucose a metabolic marker were measured. RESULTS: Women with EGWG had low adiponectin levels than women with adequate weight gain (AWG) or insufficient weight gain (IWG). Multiple linear regression models revealed a positive association between adiponectin and 8-oxodG in women with AWG (B = 1.09, 95% CI: 164-222, p = 0.027) and IWG (B = 0.860, 95% CI: 0.199-1.52, p = 0.013) but not in women with EGWG. In women with EGWG, leptin was positively associated with LOOH (p = 0.018), MDA (p = 0.005), and CP (p = 0.010) oxidative markers. CONCLUSION: Our findings suggest that concurrent mechanisms regulate adipokine production and oxidative stress in pregnant women and that this regulation is influenced by GWG, probably due to an excessive AT accumulation.
Authors: Christos Chatzakis; Alexandros Sotiriadis; Ioannis G Fatouros; Athanasios Z Jamurtas; Chariklia K Deli; Maria Papagianni; Konstantinos Dinas; George Mastorakos Journal: Diagnostics (Basel) Date: 2022-07-16