Literature DB >> 34532714

Detecting context-dependent gene regulation.

Eric R Gamazon1.   

Abstract

Detection of molecular quantitative trait loci (QTL) facilitates mechanistic insights into disease-associated genetic variants. A new study describes BaseQTL, which exploits allele-specific expression to map molecular QTL from sequencing reads even without paired genotype data.

Entities:  

Year:  2021        PMID： 34532714      PMCID： PMC8439414          DOI： 10.1038/s43588-021-00092-1

Source DB:  PubMed          Journal:  Nat Comput Sci        ISSN： 2662-8457


  8 in total

1.  A statistical framework for eQTL mapping using RNA-seq data.

Authors:  Wei Sun
Journal:  Biometrics       Date:  2011-08-12       Impact factor: 2.571

2.  The GTEx Consortium atlas of genetic regulatory effects across human tissues.

Authors: 
Journal:  Science       Date:  2020-09-11       Impact factor: 47.728

3.  Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.

Authors:  Helena Kilpinen; Sebastian M Waszak; Andreas R Gschwind; Sunil K Raghav; Robert M Witwicki; Andrea Orioli; Eugenia Migliavacca; Michaël Wiederkehr; Maria Gutierrez-Arcelus; Nikolaos I Panousis; Alisa Yurovsky; Tuuli Lappalainen; Luciana Romano-Palumbo; Alexandra Planchon; Deborah Bielser; Julien Bryois; Ismael Padioleau; Gilles Udin; Sarah Thurnheer; David Hacker; Leighton J Core; John T Lis; Nouria Hernandez; Alexandre Reymond; Bart Deplancke; Emmanouil T Dermitzakis
Journal:  Science       Date:  2013-10-17       Impact factor: 47.728

4.  Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans.

Authors: 
Journal:  Science       Date:  2015-05-07       Impact factor: 47.728

5.  Dynamic genetic regulation of gene expression during cellular differentiation.

Authors:  B J Strober; R Elorbany; K Rhodes; N Krishnan; K Tayeb; A Battle; Y Gilad
Journal:  Science       Date:  2019-06-28       Impact factor: 63.714

6.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.

Authors:  Michael I Love; Wolfgang Huber; Simon Anders
Journal:  Genome Biol       Date:  2014       Impact factor: 13.583

7.  Allele-specific expression reveals interactions between genetic variation and environment.

Authors:  David A Knowles; Joe R Davis; Hilary Edgington; Anil Raj; Marie-Julie Favé; Xiaowei Zhu; James B Potash; Myrna M Weissman; Jianxin Shi; Douglas F Levinson; Philip Awadalla; Sara Mostafavi; Stephen B Montgomery; Alexis Battle
Journal:  Nat Methods       Date:  2017-05-22       Impact factor: 28.547

8.  Fine-mapping cellular QTLs with RASQUAL and ATAC-seq.

Authors:  Natsuhiko Kumasaka; Andrew J Knights; Daniel J Gaffney
Journal:  Nat Genet       Date:  2015-12-14       Impact factor: 38.330
  8 in total

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