| Literature DB >> 34522049 |
John P DeLong1, Maitham A Al-Sammak2,3, Zeina T Al-Ameeli3,4, David D Dunigan3,5, Kyle F Edwards6, Jeffry J Fuhrmann7,8, Jason P Gleghorn8,9, Hanqun Li8,10, Kona Haramoto7,10, Amelia O Harrison7,10, Marcia F Marston11, Ryan M Moore10,12, Shawn W Polson7,8,10,12, Barbra D Ferrell10,12, Miranda E Salsbery13, Christopher R Schvarcz6, Jasmine Shirazi9, Grieg F Steward6, James L Van Etten3,5, K Eric Wommack14,15,16.
Abstract
Understanding how phenotypes emerge from genotypes is a foundational goal in biology. As challenging as this task is when considering cellular life, it is further complicated in the case of viruses. During replication, a virus as a discrete entity (the virion) disappears and manifests itself as a metabolic amalgam between the virus and the host (the virocell). Identifying traits that unambiguously constitute a virus's phenotype is straightforward for the virion, less so for the virocell. Here, we present a framework for categorizing virus phenotypes that encompasses both virion and virocell stages and considers functional and performance traits of viruses in the context of fitness. Such an integrated view of virus phenotype is necessary for comprehensive interpretation of viral genome sequences and will advance our understanding of viral evolution and ecology.Entities:
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Year: 2021 PMID： 34522049 DOI： 10.1038/s41579-021-00612-w
Source DB: PubMed Journal: Nat Rev Microbiol ISSN： 1740-1526 Impact factor: 60.633