Literature DB >> 34514871

The Mechanobiology of Vascular Remodeling in the Aging Lung.

Paul B Dieffenbach1, Aja Aravamudhan2, Laura E Fredenburgh1, Daniel J Tschumperlin2.   

Abstract

Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how interacting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.

Entities:  

Keywords:  matrix; pulmonary; senescence; stiffness; vessel

Mesh：

Year:  2021        PMID： 34514871      PMCID： PMC8742727          DOI： 10.1152/physiol.00019.2021

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  158 in total

1.  Prognostic relevance of pulmonary arterial compliance in patients with chronic heart failure.

Authors:  Paolo Pellegrini; Andrea Rossi; Michele Pasotti; Claudia Raineri; Mariantonietta Cicoira; Stefano Bonapace; Frank Lloyd Dini; Pier Luigi Temporelli; Corrado Vassanelli; Rebecca Vanderpool; Robert Naeije; Stefano Ghio
Journal:  Chest       Date:  2014-05       Impact factor: 9.410

2.  Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study.

Authors:  Pierre Boutouyrie; Anne Isabelle Tropeano; Roland Asmar; Isabelle Gautier; Athanase Benetos; Patrick Lacolley; Stéphane Laurent
Journal:  Hypertension       Date:  2002-01       Impact factor: 10.190

Review 3.  Oxidative stress and vascular inflammation in aging.

Authors:  Mariam El Assar; Javier Angulo; Leocadio Rodríguez-Mañas
Journal:  Free Radic Biol Med       Date:  2013-07-10       Impact factor: 7.376

4.  Impact of residual stretch and remodeling on collagen engagement in healthy and pulmonary hypertensive calf pulmonary arteries at physiological pressures.

Authors:  Lian Tian; Steven R Lammers; Philip H Kao; Joseph A Albietz; Kurt R Stenmark; H Jerry Qi; Robin Shandas; Kendall S Hunter
Journal:  Ann Biomed Eng       Date:  2012-01-12       Impact factor: 3.934

5.  Oxidative stress and endothelial dysfunction in pulmonary arteries of aged rats.

Authors:  Andrej Podlutsky; Praveen Ballabh; Anna Csiszar
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-12-04       Impact factor: 4.733

Review 6.  Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels.

Authors:  Edward G Lakatta; Mingyi Wang; Samer S Najjar
Journal:  Med Clin North Am       Date:  2009-05       Impact factor: 5.456

7.  Single-Cell RNA Sequencing Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells.

Authors:  David T Paik; Lei Tian; Ian M Williams; Siyeon Rhee; Hao Zhang; Chun Liu; Ridhima Mishra; Sean M Wu; Kristy Red-Horse; Joseph C Wu
Journal:  Circulation       Date:  2020-09-15       Impact factor: 29.690

8.  Age-associated increases in pulmonary artery systolic pressure in the general population.

Authors:  Carolyn S P Lam; Barry A Borlaug; Garvan C Kane; Felicity T Enders; Richard J Rodeheffer; Margaret M Redfield
Journal:  Circulation       Date:  2009-05-11       Impact factor: 29.690

Review 9.  Pulmonary vascular mechanics: important contributors to the increased right ventricular afterload of pulmonary hypertension.

Authors:  Zhijie Wang; Naomi C Chesler
Journal:  Exp Physiol       Date:  2013-05-10       Impact factor: 2.969

10.  In vivo measurement of proximal pulmonary artery elastic modulus in the neonatal calf model of pulmonary hypertension: development and ex vivo validation.

Authors:  Kendall S Hunter; Joseph A Albietz; Po-Feng Lee; Craig J Lanning; Steven R Lammers; Stephen H Hofmeister; Philip H Kao; H Jerry Qi; Kurt R Stenmark; Robin Shandas
Journal:  J Appl Physiol (1985)       Date:  2010-01-21
View more
  1 in total

1.  Single-cell transcriptome atlas of the human corpus cavernosum.

Authors:  LiangYu Zhao; Sha Han; HengChuan Su; JianYing Li; ErLei Zhi; Peng Li; ChenCheng Yao; RuHui Tian; HuiXing Chen; HuiRong Chen; JiaQiang Luo; ChenKun Shi; ZhiYong Ji; JianLin Hu; Gang Wu; WeiDong Zhou; YuXin Tang; YuZhuo Chen; GuiTing Lin; Tom F Lue; DengLong Wu; Zheng Li
Journal:  Nat Commun       Date:  2022-07-25       Impact factor: 17.694
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.