Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels.

Literature DB >> 19427493

Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels.

Edward G Lakatta¹, Mingyi Wang, Samer S Najjar.

Abstract

The structure and function of arteries change throughout a lifetime. Age is the dominant risk factor for hypertension, coronary heart disease, congestive heart failure, and stroke. The cellular/molecular proinflammatory alterations that underlie arterial aging are novel putative candidates to be targeted by interventions aimed at attenuating arterial aging as a major risk factor for cardiovascular diseases. This review provides a landscape of central arterial aging and age-disease interactions, integrating perspectives that range from humans to molecules, with the goal that future therapies for cardiovascular diseases, such as hypertension, also will target the prevention or amelioration of unsuccessful arterial aging.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Angiotensin II

Year: 2009 PMID： 19427493 PMCID： PMC2943242 DOI： 10.1016/j.mcna.2009.02.008

Source DB: PubMed Journal: Med Clin North Am ISSN： 0025-7125 Impact factor: 5.456

71 in total

Review 1. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease.

Authors: Edward G Lakatta; Daniel Levy
Journal: Circulation Date: 2003-01-21 Impact factor: 29.690

Review 2. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging.

Authors: Edward G Lakatta
Journal: Circulation Date: 2003-01-28 Impact factor: 29.690

3. Prognostic significance of endothelial dysfunction in hypertensive patients.

Authors: F Perticone; R Ceravolo; A Pujia; G Ventura; S Iacopino; A Scozzafava; A Ferraro; M Chello; P Mastroroberto; P Verdecchia; G Schillaci
Journal: Circulation Date: 2001-07-10 Impact factor: 29.690

Review 4. Arterial stiffening: opposing effects of age- and hypertension-associated structural changes.

Authors: S Laurent; P Lacolley; X Girerd; P Boutouyrie; Y Bezie; M Safar
Journal: Can J Physiol Pharmacol Date: 1996-07 Impact factor: 2.273

5. Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats.

Authors: Mingyi Wang; Jing Zhang; Gaia Spinetti; Li-Qun Jiang; Robert Monticone; Di Zhao; Linda Cheng; Melissa Krawczyk; Mark Talan; Gianfranco Pintus; Edward G Lakatta
Journal: Am J Pathol Date: 2005-11 Impact factor: 4.307

6. Homeobox protein Hex induces SMemb/nonmuscle myosin heavy chain-B gene expression through the cAMP-responsive element.

Authors: K Sekiguchi; M Kurabayashi; Y Oyama; Y Aihara; T Tanaka; H Sakamoto; Y Hoshino; T Kanda; T Yokoyama; Y Shimomura; H Iijima; Y Ohyama; R Nagai
Journal: Circ Res Date: 2001-01-19 Impact factor: 17.367

Review 7. Advanced protein glycosylation in diabetes and aging.

Authors: M Brownlee
Journal: Annu Rev Med Date: 1995 Impact factor: 13.739

8. The salted artery and angiotensin II signaling: a deadly duo in arterial disease.

Authors: Mingyi Wang; Edward G Lakatta
Journal: J Hypertens Date: 2009-01 Impact factor: 4.844

9. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities.

Authors: R Virmani; A P Avolio; W J Mergner; M Robinowitz; E E Herderick; J F Cornhill; S Y Guo; T H Liu; D Y Ou; M O'Rourke
Journal: Am J Pathol Date: 1991-11 Impact factor: 4.307

Review 10. Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage.

Authors: Gary F Mitchell
Journal: J Appl Physiol (1985) Date: 2008-09-04

93 in total

Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels.

Review 1. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease.

Review 2. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging.

3. Prognostic significance of endothelial dysfunction in hypertensive patients.

Review 4. Arterial stiffening: opposing effects of age- and hypertension-associated structural changes.

5. Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats.

6. Homeobox protein Hex induces SMemb/nonmuscle myosin heavy chain-B gene expression through the cAMP-responsive element.

Review 7. Advanced protein glycosylation in diabetes and aging.

8. The salted artery and angiotensin II signaling: a deadly duo in arterial disease.

9. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities.

Review 10. Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage.

Review 1. Pluripotency of human embryonic and induced pluripotent stem cells for cardiac and vascular regeneration.

2. Time course of carotid artery growth and remodeling in response to altered pulsatility.

3. Association between human immunodeficiency virus infection and stiffness of the common carotid artery.

Review 4. Noninvasive Imaging of Flow and Vascular Function in Disease of the Aorta.

5. Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences.

6. Impaired activity of adherens junctions contributes to endothelial dilator dysfunction in ageing rat arteries.

Review 7. Proinflammatory Arterial Stiffness Syndrome: A Signature of Large Arterial Aging.

8. PKCδ Mediates Mineralocorticoid Receptor Activation by Angiotensin II to Modulate Smooth Muscle Cell Function.

9. Loss of Elastic Fiber Integrity Compromises Common Carotid Artery Function: Implications for Vascular Aging.

10. Quantification of regional differences in aortic stiffness in the aging human.