Literature DB >> 34514509

Dynamics of the Cellular and Humoral Immune Response After BNT162b2 Messenger Ribonucleic Acid Coronavirus Disease 2019 (COVID-19) Vaccination in COVID-19-Naive Nursing Home Residents.

Jens T Van Praet1,2, Stefaan Vandecasteele1, Anneleen De Roo3, Matthijs Vynck4, An S De Vriese1,2, Marijke Reynders5.   

Abstract

Short-term humoral and cellular immune responses are diminished after BNT162b2 messenger ribonucleic acid coronavirus disease 2019 (COVID-19) vaccination in COVID-19-naive nursing home residents, a population particularly vulnerable to the disease. We found both responses to decline after 4 weeks and remain lower than those of healthcare workers after 24 weeks, with an estimated half-life of the antibody response of 47 days. At 4 weeks, older age was significantly associated with a decreased humoral response, and diabetes mellitus and active malignancy were associated with a decreased cellular response. Our results imply that COVID-19-naive nursing home residents are a target group for booster vaccination trials.
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  19; 19 vaccine; 2; BNT162b2 mRNA COVID; COVID; CoV; SARS; nursing home residents

Mesh：

Substances：

Year:  2021        PMID： 34514509     DOI： 10.1093/infdis/jiab458

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   7.759


  16 in total

1.  Association of Receipt of the Fourth BNT162b2 Dose With Omicron Infection and COVID-19 Hospitalizations Among Residents of Long-term Care Facilities.

Authors:  Khitam Muhsen; Nimrod Maimon; Amiel Yaron Mizrahi; Boris Boltyansky; Omri Bodenheimer; Zafrira Hillel Diamant; Lea Gaon; Dani Cohen; Ron Dagan
Journal:  JAMA Intern Med       Date:  2022-08-01       Impact factor: 44.409

2.  Reduced humoral response 3 months following BNT162b2 vaccination in SARS-CoV-2 uninfected residents of long-term care facilities.

Authors:  Macedonia Trigueros; Edwards Pradenas; Dolors Palacín; Francisco Muñoz-López; Carlos Ávila-Nieto; Benjamin Trinité; Josep Maria Bonet-Simó; Mar Isnard; Nemesio Moreno; Silvia Marfil; Carla Rovirosa; Teresa Puig; Eulàlia Grau; Anna Chamorro; Ana Martinez; Ruth Toledo; Marta Font; Jordi Ara; Jorge Carrillo; Lourdes Mateu; Julià Blanco; Bonaventura Clotet; Nuria Prat; Marta Massanella
Journal:  Age Ageing       Date:  2022-05-01       Impact factor: 12.782

3.  Association of Impaired Fasting Glucose and Diabetes with SARS-CoV-2 Spike Antibody Titers after the BNT162b2 Vaccine among Health Care Workers in a Tertiary Hospital in Japan.

Authors:  Zobida Islam; Shohei Yamamoto; Tetsuya Mizoue; Akihito Tanaka; Yusuke Oshiro; Natsumi Inamura; Maki Konishi; Mitsuru Ozeki; Wataru Sugiura; Norio Ohmagari
Journal:  Vaccines (Basel)       Date:  2022-05-13

4.  Effects of Loigolactobacillus coryniformis K8 CECT 5711 on the Immune Response of Elderly Subjects to COVID-19 Vaccination: A Randomized Controlled Trial.

Authors:  Anxo Fernández-Ferreiro; Francisco J Formigo-Couceiro; Roi Veiga-Gutierrez; Jose A Maldonado-Lobón; Ana M Hermida-Cao; Carlos Rodriguez; Oscar Bañuelos; Mónica Olivares; Ruth Blanco-Rojo
Journal:  Nutrients       Date:  2022-01-05       Impact factor: 5.717

5.  Performance comparison of a flow cytometry immunoassay for intracellular cytokine staining and the QuantiFERON® SARS-CoV-2 test for detection and quantification of SARS-CoV-2-Spike-reactive-IFN-γ-producing T cells after COVID-19 vaccination.

Authors:  Nuria Tormo; Estela Giménez; María Martínez-Navarro; Eliseo Albert; David Navalpotro; Ignacio Torres; Concepción Gimeno; David Navarro
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2022-02-15       Impact factor: 5.103

6.  SARS-CoV-2 adaptive immunity in nursing home residents up to eight months after two doses of the Comirnaty® COVID-19 vaccine.

Authors:  Estela Giménez; Eliseo Albert; Javier S Burgos; Salvador Peiró; Dolores Salas; Hermelinda Vanaclocha; Ramón Limón; María Jesús Alcaraz; José Sánchez-Payá; Javier Díez-Domingo; Iñaki Comas; Fernando Gonzáles-Candelas
Journal:  J Infect       Date:  2022-03-02       Impact factor: 38.637

7.  Third dose of COVID-19 vaccine in diabetes: Relevance of good metabolic control to improve its efficacy.

Authors:  Silvia Pieralice; Luca D'Onofrio; Paolo Pozzilli; Raffaella Buzzetti
Journal:  Diabetes Metab Res Rev       Date:  2022-04-30       Impact factor: 8.128

8.  Association of BNT162b2 Vaccine Third Dose Receipt With Incidence of SARS-CoV-2 Infection, COVID-19-Related Hospitalization, and Death Among Residents of Long-term Care Facilities, August to October 2021.

Authors:  Khitam Muhsen; Nimrod Maimon; Amiel Yaron Mizrahi; Baruch Varticovschi; Omri Bodenheimer; Dani Cohen; Ron Dagan
Journal:  JAMA Netw Open       Date:  2022-07-01

Review 9.  The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection.

Authors:  Esther Moga; Elionor Lynton-Pons; Pere Domingo
Journal:  Front Immunol       Date:  2022-06-27       Impact factor: 8.786

10.  Humoral and Cellular Response after mRNA Vaccination in Nursing Homes: Influence of Age and of History of COVID-19.

Authors:  Jesús San Román; Francisco Javier Candel; Juan Carlos Sanz; Paloma López; Rocío Menéndez-Colino; Pablo Barreiro; María Del Mar Carretero; Marta Pérez-Abeledo; José Manuel Viñuela-Prieto; Belén Ramos; Jesús Canora; Raquel Barba; Antonio Zapatero-Gaviria; Franciso Javier Martínez-Peromingo
Journal:  Vaccines (Basel)       Date:  2022-03-02
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