| Literature DB >> 34511735 |
Adrian Elter1,2, Jan P Bogen1,3, Jan Habermann1, Harald Kolmar1,4.
Abstract
Due to the large evolutionary distance between birds (Aves) und humans, immunization of chickens with human proteins results in a strong response of the bird's adaptive immune system to proteins of mammalian origin. Additionally, chicken-derived antibodies display less undesired cross-reactivity in analytical setups than conventional rodent-derived antibodies. Due to these features as well as the facile amplification of antibody-coding genes, chicken-derived antibodies emerged as promising molecules for the immunotherapy and various biotechnological applications. © Die Autoren 2021.Entities:
Year: 2021 PMID: 34511735 PMCID: PMC8417631 DOI: 10.1007/s12268-021-1623-3
Source DB: PubMed Journal: Biospektrum (Heidelb) ISSN: 0947-0867