| Literature DB >> 34508697 |
Dushani L Palliyaguru1, Eric J Shiroma2, John K Nam1, Eleonora Duregon1, Camila Vieira Ligo Teixeira1, Nathan L Price3, Michel Bernier1, Simonetta Camandola1, Kelli L Vaughan1, Ricki J Colman4, Andrew Deighan5, Ron Korstanje5, Luanne L Peters5, Stephanie L Dickinson6, Keisuke Ejima6, Eleanor M Simonsick1, Lenore J Launer2, Chee W Chia7, Josephine Egan7, David B Allison6, Gary A Churchill5, Rozalyn M Anderson8, Luigi Ferrucci1, Julie A Mattison1, Rafael de Cabo9.
Abstract
Aging leads to profound changes in glucose homeostasis, weight, and adiposity, which are considered good predictors of health and survival in humans. Direct evidence that these age-associated metabolic alterations are recapitulated in animal models is lacking, impeding progress to develop and test interventions that delay the onset of metabolic dysfunction and promote healthy aging and longevity. We compared longitudinal trajectories, rates of change, and mortality risks of fasting blood glucose, body weight, and fat mass in mice, nonhuman primates, and humans throughout their lifespans and found similar trajectories of body weight and fat in the three species. In contrast, fasting blood glucose decreased late in life in mice but increased over the lifespan of nonhuman primates and humans. Higher glucose was associated with lower mortality in mice but higher mortality in nonhuman primates and humans, providing a cautionary tale for translating age-associated metabolic changes from mice to humans. Published by Elsevier Inc.Entities:
Keywords: fasting blood glucose; humans; metabolism; mice; mortality; nonhuman primates; predictors
Mesh：
Substances：
Year: 2021 PMID： 34508697 PMCID： PMC9115768 DOI： 10.1016/j.cmet.2021.08.013
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 31.373