| Literature DB >> 34497375 |
Haeun Kwon1, Quynh Nhu Nguyen2, Myung Woo Na3, Ki Hyun Kim3, Yuanqiang Guo4, Joung Han Yim5, Sang Hee Shim6, Jae-Jin Kim7, Ki Sung Kang8, Dongho Lee9.
Abstract
A new α-pyrone analog, arthrifuranone A (1) was isolated from an EtOAc-extract of Arthrinium pseudosinense culture medium. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using MS and NMR spectroscopic techniques, and the absolute configuration was established by the Mosher's method and gauge-including atomic orbital NMR chemical shift calculations, followed by DP4 + analysis. The isolated compound was evaluated for its estrogenic activity using the MCF-7 estrogen responsive human breast cancer cells. Compound 1 showed estrogenic activity by increasing the proliferation of MCF-7 cells at the concentration of 3.125 μM via phosphorylation of estrogen receptor-α.Entities:
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Year: 2021 PMID： 34497375 DOI： 10.1038/s41429-021-00473-8
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649