Literature DB >> 34493870

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.

Ole A Andreassen1,2,3, Danielle Posthuma4,5, Douglas P Wightman6, Iris E Jansen6, Jeanne E Savage6, Alexey A Shadrin1,2, Shahram Bahrami1,2,3, Dominic Holland7, Arvid Rongve8,9, Sigrid Børte2,10,11, Bendik S Winsvold11,12,13, Ole Kristian Drange14,15, Amy E Martinsen2,11,12, Anne Heidi Skogholt11,16, Cristen Willer17, Geir Bråthen18,19,20, Ingunn Bosnes14,21, Jonas Bille Nielsen11,17,22, Lars G Fritsche23, Laurent F Thomas11,16, Linda M Pedersen12, Maiken E Gabrielsen11, Marianne Bakke Johnsen2,10,11, Tore Wergeland Meisingset18,19, Wei Zhou24,25, Petroula Proitsi26, Angela Hodges26, Richard Dobson27,28,29,30,31, Latha Velayudhan26, Karl Heilbron32, Adam Auton32, Julia M Sealock33,34, Lea K Davis33,34, Nancy L Pedersen35, Chandra A Reynolds36, Ida K Karlsson35,37, Sigurdur Magnusson38, Hreinn Stefansson38, Steinunn Thordardottir39, Palmi V Jonsson39,40, Jon Snaedal39, Anna Zettergren41, Ingmar Skoog41,42, Silke Kern41,42, Margda Waern41,43, Henrik Zetterberg44,45,46,47, Kaj Blennow46,47, Eystein Stordal14,21, Kristian Hveem11,48, John-Anker Zwart2,11,12, Lavinia Athanasiu1,3, Per Selnes49, Ingvild Saltvedt18,20, Sigrid B Sando18,19, Ingun Ulstein50, Srdjan Djurovic51,52, Tormod Fladby2,49, Dag Aarsland26,53, Geir Selbæk2,50,54, Stephan Ripke25,55,56, Kari Stefansson38.   

Abstract

Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts for 50-70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer's disease have been identified. Here we show that increased sample sizes allowed identification of seven previously unidentified genetic loci contributing to Alzheimer's disease. This study highlights microglia, immune cells and protein catabolism as relevant to late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest. We anticipate that these results can be included in larger meta-analyses of Alzheimer's disease to identify further genetic variants that contribute to Alzheimer's pathology.
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Year:  2021        PMID： 34493870     DOI： 10.1038/s41588-021-00921-z

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   41.307


  88 in total

1.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.

Authors:  Brendan K Bulik-Sullivan; Po-Ru Loh; Hilary K Finucane; Stephan Ripke; Jian Yang; Nick Patterson; Mark J Daly; Alkes L Price; Benjamin M Neale
Journal:  Nat Genet       Date:  2015-02-02       Impact factor: 38.330

2.  Heritability for Alzheimer's disease: the study of dementia in Swedish twins.

Authors:  M Gatz; N L Pedersen; S Berg; B Johansson; K Johansson; J A Mortimer; S F Posner; M Viitanen; B Winblad; A Ahlbom
Journal:  J Gerontol A Biol Sci Med Sci       Date:  1997-03       Impact factor: 6.053

Review 3.  Defeating Alzheimer's disease and other dementias: a priority for European science and society.

Authors:  Bengt Winblad; Philippe Amouyel; Sandrine Andrieu; Clive Ballard; Carol Brayne; Henry Brodaty; Angel Cedazo-Minguez; Bruno Dubois; David Edvardsson; Howard Feldman; Laura Fratiglioni; Giovanni B Frisoni; Serge Gauthier; Jean Georges; Caroline Graff; Khalid Iqbal; Frank Jessen; Gunilla Johansson; Linus Jönsson; Miia Kivipelto; Martin Knapp; Francesca Mangialasche; René Melis; Agneta Nordberg; Marcel Olde Rikkert; Chengxuan Qiu; Thomas P Sakmar; Philip Scheltens; Lon S Schneider; Reisa Sperling; Lars O Tjernberg; Gunhild Waldemar; Anders Wimo; Henrik Zetterberg
Journal:  Lancet Neurol       Date:  2016-04       Impact factor: 44.182

4.  Role of genes and environments for explaining Alzheimer disease.

Authors:  Margaret Gatz; Chandra A Reynolds; Laura Fratiglioni; Boo Johansson; James A Mortimer; Stig Berg; Amy Fiske; Nancy L Pedersen
Journal:  Arch Gen Psychiatry       Date:  2006-02

5.  Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.

Authors:  Iris E Jansen; Jeanne E Savage; Stephan Ripke; Ole A Andreassen; Danielle Posthuma; Kyoko Watanabe; Julien Bryois; Dylan M Williams; Stacy Steinberg; Julia Sealock; Ida K Karlsson; Sara Hägg; Lavinia Athanasiu; Nicola Voyle; Petroula Proitsi; Aree Witoelar; Sven Stringer; Dag Aarsland; Ina S Almdahl; Fred Andersen; Sverre Bergh; Francesco Bettella; Sigurbjorn Bjornsson; Anne Brækhus; Geir Bråthen; Christiaan de Leeuw; Rahul S Desikan; Srdjan Djurovic; Logan Dumitrescu; Tormod Fladby; Timothy J Hohman; Palmi V Jonsson; Steven J Kiddle; Arvid Rongve; Ingvild Saltvedt; Sigrid B Sando; Geir Selbæk; Maryam Shoai; Nathan G Skene; Jon Snaedal; Eystein Stordal; Ingun D Ulstein; Yunpeng Wang; Linda R White; John Hardy; Jens Hjerling-Leffler; Patrick F Sullivan; Wiesje M van der Flier; Richard Dobson; Lea K Davis; Hreinn Stefansson; Kari Stefansson; Nancy L Pedersen
Journal:  Nat Genet       Date:  2019-01-07       Impact factor: 38.330

6.  The genetic architecture of human complex phenotypes is modulated by linkage disequilibrium and heterozygosity.

Authors:  Dominic Holland; Oleksandr Frei; Rahul Desikan; Chun-Chieh Fan; Alexey A Shadrin; Olav B Smeland; Ole A Andreassen; Anders M Dale
Journal:  Genetics       Date:  2021-03-31       Impact factor: 4.562

7.  A Systematic Review and Meta-Analysis on the Prevalence of Dementia in Europe: Estimates from the Highest-Quality Studies Adopting the DSM IV Diagnostic Criteria.

Authors:  Ilaria Bacigalupo; Flavia Mayer; Eleonora Lacorte; Alessandra Di Pucchio; Fabrizio Marzolini; Marco Canevelli; Teresa Di Fiandra; Nicola Vanacore
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

8.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

Authors:  J C Lambert; C A Ibrahim-Verbaas; D Harold; A C Naj; R Sims; C Bellenguez; A L DeStafano; J C Bis; G W Beecham; B Grenier-Boley; G Russo; T A Thorton-Wells; N Jones; A V Smith; V Chouraki; C Thomas; M A Ikram; D Zelenika; B N Vardarajan; Y Kamatani; C F Lin; A Gerrish; H Schmidt; B Kunkle; M L Dunstan; A Ruiz; M T Bihoreau; S H Choi; C Reitz; F Pasquier; C Cruchaga; D Craig; N Amin; C Berr; O L Lopez; P L De Jager; V Deramecourt; J A Johnston; D Evans; S Lovestone; L Letenneur; F J Morón; D C Rubinsztein; G Eiriksdottir; K Sleegers; A M Goate; N Fiévet; M W Huentelman; M Gill; K Brown; M I Kamboh; L Keller; P Barberger-Gateau; B McGuiness; E B Larson; R Green; A J Myers; C Dufouil; S Todd; D Wallon; S Love; E Rogaeva; J Gallacher; P St George-Hyslop; J Clarimon; A Lleo; A Bayer; D W Tsuang; L Yu; M Tsolaki; P Bossù; G Spalletta; P Proitsi; J Collinge; S Sorbi; F Sanchez-Garcia; N C Fox; J Hardy; M C Deniz Naranjo; P Bosco; R Clarke; C Brayne; D Galimberti; M Mancuso; F Matthews; S Moebus; P Mecocci; M Del Zompo; W Maier; H Hampel; A Pilotto; M Bullido; F Panza; P Caffarra; B Nacmias; J R Gilbert; M Mayhaus; L Lannefelt; H Hakonarson; S Pichler; M M Carrasquillo; M Ingelsson; D Beekly; V Alvarez; F Zou; O Valladares; S G Younkin; E Coto; K L Hamilton-Nelson; W Gu; C Razquin; P Pastor; I Mateo; M J Owen; K M Faber; P V Jonsson; O Combarros; M C O'Donovan; L B Cantwell; H Soininen; D Blacker; S Mead; T H Mosley; D A Bennett; T B Harris; L Fratiglioni; C Holmes; R F de Bruijn; P Passmore; T J Montine; K Bettens; J I Rotter; A Brice; K Morgan; T M Foroud; W A Kukull; D Hannequin; J F Powell; M A Nalls; K Ritchie; K L Lunetta; J S Kauwe; E Boerwinkle; M Riemenschneider; M Boada; M Hiltuenen; E R Martin; R Schmidt; D Rujescu; L S Wang; J F Dartigues; R Mayeux; C Tzourio; A Hofman; M M Nöthen; C Graff; B M Psaty; L Jones; J L Haines; P A Holmans; M Lathrop; M A Pericak-Vance; L J Launer; L A Farrer; C M van Duijn; C Van Broeckhoven; V Moskvina; S Seshadri; J Williams; G D Schellenberg; P Amouyel
Journal:  Nat Genet       Date:  2013-10-27       Impact factor: 38.330

Review 9.  The neuropathological diagnosis of Alzheimer's disease.

Authors:  Michael A DeTure; Dennis W Dickson
Journal:  Mol Neurodegener       Date:  2019-08-02       Impact factor: 14.195

10.  Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture.

Authors:  Qian Zhang; Julia Sidorenko; Baptiste Couvy-Duchesne; Riccardo E Marioni; Margaret J Wright; Alison M Goate; Edoardo Marcora; Kuan-Lin Huang; Tenielle Porter; Simon M Laws; Perminder S Sachdev; Karen A Mather; Nicola J Armstrong; Anbupalam Thalamuthu; Henry Brodaty; Loic Yengo; Jian Yang; Naomi R Wray; Allan F McRae; Peter M Visscher
Journal:  Nat Commun       Date:  2020-09-23       Impact factor: 14.919
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  58 in total

Review 1.  Genetics of Alzheimer's disease: an East Asian perspective.

Authors:  Akinori Miyashita; Masataka Kikuchi; Norikazu Hara; Takeshi Ikeuchi
Journal:  J Hum Genet       Date:  2022-06-01       Impact factor: 3.172

Review 2.  Role of Pharmacogenomics in Individualizing Treatment for Alzheimer's Disease.

Authors:  Natalie Argueta; Emily Notari; Kinga Szigeti
Journal:  CNS Drugs       Date:  2022-03-30       Impact factor: 5.749

3.  Cognitive performance protects against Alzheimer's disease independently of educational attainment and intelligence.

Authors:  Yang Hu; Yan Zhang; Haihua Zhang; Shan Gao; Longcai Wang; Tao Wang; Zhifa Han; Bao-Liang Sun; Guiyou Liu
Journal:  Mol Psychiatry       Date:  2022-07-15       Impact factor: 13.437

4.  GRN Mutations Are Associated with Lewy Body Dementia.

Authors:  Paolo Reho; Shunsuke Koga; Zalak Shah; Ruth Chia; Rosa Rademakers; Clifton L Dalgard; Bradley F Boeve; Thomas G Beach; Dennis W Dickson; Owen A Ross; Sonja W Scholz
Journal:  Mov Disord       Date:  2022-07-10       Impact factor: 9.698

5.  Polygenic Scores of Alzheimer's Disease Risk Genes Add Only Modestly to APOE in Explaining Variation in Amyloid PET Burden.

Authors:  Vijay K Ramanan; Michael G Heckman; Scott A Przybelski; Timothy G Lesnick; Val J Lowe; Jonathan Graff-Radford; M Mielke; Clifford R Jack; David S Knopman; Ronald C Petersen; Owen A Ross; Prashanthi Vemuri
Journal:  J Alzheimers Dis       Date:  2022       Impact factor: 4.160

Review 6.  Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics.

Authors:  Lucia Migliore; Fabio Coppedè
Journal:  Nat Rev Neurol       Date:  2022-09-30       Impact factor: 44.711

Review 7.  Limbic-Predominant Age-Related TDP-43 Encephalopathy: LATE-Breaking Updates in Clinicopathologic Features and Biomarkers.

Authors:  Michael Tran Duong; David A Wolk
Journal:  Curr Neurol Neurosci Rep       Date:  2022-10-03       Impact factor: 6.030

8.  Identifying candidate genes and drug targets for Alzheimer's disease by an integrative network approach using genetic and brain region-specific proteomic data.

Authors:  Andi Liu; Astrid M Manuel; Yulin Dai; Brisa S Fernandes; Nitesh Enduru; Peilin Jia; Zhongming Zhao
Journal:  Hum Mol Genet       Date:  2022-09-29       Impact factor: 5.121

9.  New insights into the genetic etiology of Alzheimer's disease and related dementias.

Authors:  Céline Bellenguez; Fahri Küçükali; Iris E Jansen; Luca Kleineidam; Sonia Moreno-Grau; Najaf Amin; Adam C Naj; Rafael Campos-Martin; Mikko Hiltunen; Kristel Sleegers; Gerard D Schellenberg; Cornelia M van Duijn; Rebecca Sims; Wiesje M van der Flier; Agustín Ruiz; Alfredo Ramirez; Jean-Charles Lambert; Benjamin Grenier-Boley; Victor Andrade; Peter A Holmans; Anne Boland; Vincent Damotte; Sven J van der Lee; Marcos R Costa; Teemu Kuulasmaa; Qiong Yang; Itziar de Rojas; Joshua C Bis; Amber Yaqub; Ivana Prokic; Julien Chapuis; Shahzad Ahmad; Vilmantas Giedraitis; Dag Aarsland; Pablo Garcia-Gonzalez; Carla Abdelnour; Emilio Alarcón-Martín; Daniel Alcolea; Montserrat Alegret; Ignacio Alvarez; Victoria Álvarez; Nicola J Armstrong; Anthoula Tsolaki; Carmen Antúnez; Ildebrando Appollonio; Marina Arcaro; Silvana Archetti; Alfonso Arias Pastor; Beatrice Arosio; Lavinia Athanasiu; Henri Bailly; Nerisa Banaj; Miquel Baquero; Sandra Barral; Alexa Beiser; Ana Belén Pastor; Jennifer E Below; Penelope Benchek; Luisa Benussi; Claudine Berr; Céline Besse; Valentina Bessi; Giuliano Binetti; Alessandra Bizarro; Rafael Blesa; Mercè Boada; Eric Boerwinkle; Barbara Borroni; Silvia Boschi; Paola Bossù; Geir Bråthen; Jan Bressler; Catherine Bresner; Henry Brodaty; Keeley J Brookes; Luis Ignacio Brusco; Dolores Buiza-Rueda; Katharina Bûrger; Vanessa Burholt; William S Bush; Miguel Calero; Laura B Cantwell; Geneviève Chene; Jaeyoon Chung; Michael L Cuccaro; Ángel Carracedo; Roberta Cecchetti; Laura Cervera-Carles; Camille Charbonnier; Hung-Hsin Chen; Caterina Chillotti; Simona Ciccone; Jurgen A H R Claassen; Christopher Clark; Elisa Conti; Anaïs Corma-Gómez; Emanuele Costantini; Carlo Custodero; Delphine Daian; Maria Carolina Dalmasso; Antonio Daniele; Efthimios Dardiotis; Jean-François Dartigues; Peter Paul de Deyn; Katia de Paiva Lopes; Lot D de Witte; Stéphanie Debette; Jürgen Deckert; Teodoro Del Ser; Nicola Denning; Anita DeStefano; Martin Dichgans; Janine Diehl-Schmid; Mónica Diez-Fairen; Paolo Dionigi Rossi; Srdjan Djurovic; Emmanuelle Duron; Emrah Düzel; Carole Dufouil; Gudny Eiriksdottir; Sebastiaan Engelborghs; Valentina Escott-Price; Ana Espinosa; Michael Ewers; Kelley M Faber; Tagliavini Fabrizio; Sune Fallgaard Nielsen; David W Fardo; Lucia Farotti; Chiara Fenoglio; Marta Fernández-Fuertes; Raffaele Ferrari; Catarina B Ferreira; Evelyn Ferri; Bertrand Fin; Peter Fischer; Tormod Fladby; Klaus Fließbach; Bernard Fongang; Myriam Fornage; Juan Fortea; Tatiana M Foroud; Silvia Fostinelli; Nick C Fox; Emlio Franco-Macías; María J Bullido; Ana Frank-García; Lutz Froelich; Brian Fulton-Howard; Daniela Galimberti; Jose Maria García-Alberca; Pablo García-González; Sebastian Garcia-Madrona; Guillermo Garcia-Ribas; Roberta Ghidoni; Ina Giegling; Giaccone Giorgio; Alison M Goate; Oliver Goldhardt; Duber Gomez-Fonseca; Antonio González-Pérez; Caroline Graff; Giulia Grande; Emma Green; Timo Grimmer; Edna Grünblatt; Michelle Grunin; Vilmundur Gudnason; Tamar Guetta-Baranes; Annakaisa Haapasalo; Georgios Hadjigeorgiou; Jonathan L Haines; Kara L Hamilton-Nelson; Harald Hampel; Olivier Hanon; John Hardy; Annette M Hartmann; Lucrezia Hausner; Janet Harwood; Stefanie Heilmann-Heimbach; Seppo Helisalmi; Michael T Heneka; Isabel Hernández; Martin J Herrmann; Per Hoffmann; Clive Holmes; Henne Holstege; Raquel Huerto Vilas; Marc Hulsman; Jack Humphrey; Geert Jan Biessels; Xueqiu Jian; Charlotte Johansson; Gyungah R Jun; Yuriko Kastumata; John Kauwe; Patrick G Kehoe; Lena Kilander; Anne Kinhult Ståhlbom; Miia Kivipelto; Anne Koivisto; Johannes Kornhuber; Mary H Kosmidis; Walter A Kukull; Pavel P Kuksa; Brian W Kunkle; Amanda B Kuzma; Carmen Lage; Erika J Laukka; Lenore Launer; Alessandra Lauria; Chien-Yueh Lee; Jenni Lehtisalo; Ondrej Lerch; Alberto Lleó; William Longstreth; Oscar Lopez; Adolfo Lopez de Munain; Seth Love; Malin Löwemark; Lauren Luckcuck; Kathryn L Lunetta; Yiyi Ma; Juan Macías; Catherine A MacLeod; Wolfgang Maier; Francesca Mangialasche; Marco Spallazzi; Marta Marquié; Rachel Marshall; Eden R Martin; Angel Martín Montes; Carmen Martínez Rodríguez; Carlo Masullo; Richard Mayeux; Simon Mead; Patrizia Mecocci; Miguel Medina; Alun Meggy; Shima Mehrabian; Silvia Mendoza; Manuel Menéndez-González; Pablo Mir; Susanne Moebus; Merel Mol; Laura Molina-Porcel; Laura Montrreal; Laura Morelli; Fermin Moreno; Kevin Morgan; Thomas Mosley; Markus M Nöthen; Carolina Muchnik; Shubhabrata Mukherjee; Benedetta Nacmias; Tiia Ngandu; Gael Nicolas; Børge G Nordestgaard; Robert Olaso; Adelina Orellana; Michela Orsini; Gemma Ortega; Alessandro Padovani; Caffarra Paolo; Goran Papenberg; Lucilla Parnetti; Florence Pasquier; Pau Pastor; Gina Peloso; Alba Pérez-Cordón; Jordi Pérez-Tur; Pierre Pericard; Oliver Peters; Yolande A L Pijnenburg; Juan A Pineda; Gerard Piñol-Ripoll; Claudia Pisanu; Thomas Polak; Julius Popp; Danielle Posthuma; Josef Priller; Raquel Puerta; Olivier Quenez; Inés Quintela; Jesper Qvist Thomassen; Alberto Rábano; Innocenzo Rainero; Farid Rajabli; Inez Ramakers; Luis M Real; Marcel J T Reinders; Christiane Reitz; Dolly Reyes-Dumeyer; Perry Ridge; Steffi Riedel-Heller; Peter Riederer; Natalia Roberto; Eloy Rodriguez-Rodriguez; Arvid Rongve; Irene Rosas Allende; Maitée Rosende-Roca; Jose Luis Royo; Elisa Rubino; Dan Rujescu; María Eugenia Sáez; Paraskevi Sakka; Ingvild Saltvedt; Ángela Sanabria; María Bernal Sánchez-Arjona; Florentino Sanchez-Garcia; Pascual Sánchez Juan; Raquel Sánchez-Valle; Sigrid B Sando; Chloé Sarnowski; Claudia L Satizabal; Michela Scamosci; Nikolaos Scarmeas; Elio Scarpini; Philip Scheltens; Norbert Scherbaum; Martin Scherer; Matthias Schmid; Anja Schneider; Jonathan M Schott; Geir Selbæk; Davide Seripa; Manuel Serrano; Jin Sha; Alexey A Shadrin; Olivia Skrobot; Susan Slifer; Gijsje J L Snijders; Hilkka Soininen; Vincenzo Solfrizzi; Alina Solomon; Yeunjoo Song; Sandro Sorbi; Oscar Sotolongo-Grau; Gianfranco Spalletta; Annika Spottke; Alessio Squassina; Eystein Stordal; Juan Pablo Tartan; Lluís Tárraga; Niccolo Tesí; Anbupalam Thalamuthu; Tegos Thomas; Giuseppe Tosto; Latchezar Traykov; Lucio Tremolizzo; Anne Tybjærg-Hansen; Andre Uitterlinden; Abbe Ullgren; Ingun Ulstein; Sergi Valero; Otto Valladares; Christine Van Broeckhoven; Jeffery Vance; Badri N Vardarajan; Aad van der Lugt; Jasper Van Dongen; Jeroen van Rooij; John van Swieten; Rik Vandenberghe; Frans Verhey; Jean-Sébastien Vidal; Jonathan Vogelgsang; Martin Vyhnalek; Michael Wagner; David Wallon; Li-San Wang; Ruiqi Wang; Leonie Weinhold; Jens Wiltfang; Gill Windle; Bob Woods; Mary Yannakoulia; Habil Zare; Yi Zhao; Xiaoling Zhang; Congcong Zhu; Miren Zulaica; Lindsay A Farrer; Bruce M Psaty; Mohsen Ghanbari; Towfique Raj; Perminder Sachdev; Karen Mather; Frank Jessen; M Arfan Ikram; Alexandre de Mendonça; Jakub Hort; Magda Tsolaki; Margaret A Pericak-Vance; Philippe Amouyel; Julie Williams; Ruth Frikke-Schmidt; Jordi Clarimon; Jean-François Deleuze; Giacomina Rossi; Sudha Seshadri; Ole A Andreassen; Martin Ingelsson
Journal:  Nat Genet       Date:  2022-04-04       Impact factor: 41.307

10.  Genome-Wide Association Study of Potential Meat Quality Trait Loci in Ducks.

Authors:  Qixin Guo; Lan Huang; Hao Bai; Zhixiu Wang; Yulin Bi; Guohong Chen; Yong Jiang; Guobin Chang
Journal:  Genes (Basel)       Date:  2022-05-31       Impact factor: 4.141
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