Literature DB >> 34487294

Seeing the forest and the tree: TILs and PD-L1 as immune biomarkers.

Peter Savas1,2, Roberto Salgado1,3, Sherene Loi4,5.   

Abstract

Here we will provide an immune-focussed overview of biomarkers in early and advanced stage breast cancer. It should be noted from the outset that all the biomarkers under discussion here have not been tested in prospective clinical trials to determine their predictive performance. Such trials require very large sample sizes due to the statistical burden of testing an interaction between a treatment and a biomarker, which is compounded by the heterogeneous biology of breast cancer (Polley et al. in J Natl Cancer Inst 105:1677-1683 2013 [1]). For a detailed discussion of the immunobiology of breast cancer, analytical aspects of these biomarkers, emerging biomarkers such as tumour mutation burden and detailed immunotherapy clinical trial data, see other articles in this issue.
© 2021. Crown.

Entities:  

Keywords:  Biomarkers; Breast cancer; Immunotherapy; PD-L1; Tumour-infiltrating lymphocytes

Mesh：

Substances：

Year:  2021        PMID： 34487294     DOI： 10.1007/s10549-021-06287-4

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN： 0167-6806            Impact factor:   4.872


  56 in total

1.  Statistical and practical considerations for clinical evaluation of predictive biomarkers.

Authors:  Mei-Yin C Polley; Boris Freidlin; Edward L Korn; Barbara A Conley; Jeffrey S Abrams; Lisa M McShane
Journal:  J Natl Cancer Inst       Date:  2013-10-17       Impact factor: 13.506

2.  LIFE EXPECTANCY FOLLOWING RADICAL AMPUTATION FOR CARCINOMA OF THE BREAST: A CLINICAL AND PATHOLOGIC STUDY OF 218 CASES.

Authors:  W E Sistrunk; W C Maccarty
Journal:  Ann Surg       Date:  1922-01       Impact factor: 12.969

3.  A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging.

Authors:  Leeat Keren; Marc Bosse; Diana Marquez; Roshan Angoshtari; Samir Jain; Sushama Varma; Soo-Ryum Yang; Allison Kurian; David Van Valen; Robert West; Sean C Bendall; Michael Angelo
Journal:  Cell       Date:  2018-09-06       Impact factor: 41.582

4.  The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.

Authors:  R Salgado; C Denkert; S Demaria; N Sirtaine; F Klauschen; G Pruneri; S Wienert; G Van den Eynden; F L Baehner; F Penault-Llorca; E A Perez; E A Thompson; W F Symmans; A L Richardson; J Brock; C Criscitiello; H Bailey; M Ignatiadis; G Floris; J Sparano; Z Kos; T Nielsen; D L Rimm; K H Allison; J S Reis-Filho; S Loibl; C Sotiriou; G Viale; S Badve; S Adams; K Willard-Gallo; S Loi
Journal:  Ann Oncol       Date:  2014-09-11       Impact factor: 32.976

5.  Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis.

Authors:  Peter Savas; Balaji Virassamy; Chengzhong Ye; Agus Salim; Christopher P Mintoff; Franco Caramia; Roberto Salgado; David J Byrne; Zhi L Teo; Sathana Dushyanthen; Ann Byrne; Lironne Wein; Stephen J Luen; Catherine Poliness; Sophie S Nightingale; Anita S Skandarajah; David E Gyorki; Chantel M Thornton; Paul A Beavis; Stephen B Fox; Phillip K Darcy; Terence P Speed; Laura K Mackay; Paul J Neeson; Sherene Loi
Journal:  Nat Med       Date:  2018-06-25       Impact factor: 53.440

6.  Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group.

Authors:  Carsten Denkert; Stephan Wienert; Audrey Poterie; Sibylle Loibl; Jan Budczies; Sunil Badve; Zsuzsanna Bago-Horvath; Anita Bane; Shahinaz Bedri; Jane Brock; Ewa Chmielik; Matthias Christgen; Cecile Colpaert; Sandra Demaria; Gert Van den Eynden; Giuseppe Floris; Stephen B Fox; Dongxia Gao; Barbara Ingold Heppner; S Rim Kim; Zuzana Kos; Hans H Kreipe; Sunil R Lakhani; Frederique Penault-Llorca; Giancarlo Pruneri; Nina Radosevic-Robin; David L Rimm; Stuart J Schnitt; Bruno V Sinn; Peter Sinn; Nicolas Sirtaine; Sandra A O'Toole; Giuseppe Viale; Koen Van de Vijver; Roland de Wind; Gunter von Minckwitz; Frederick Klauschen; Michael Untch; Peter A Fasching; Toralf Reimer; Karen Willard-Gallo; Stefan Michiels; Sherene Loi; Roberto Salgado
Journal:  Mod Pathol       Date:  2016-07-01       Impact factor: 7.842

7.  Leukocyte composition of human breast cancer.

Authors:  Brian Ruffell; Alfred Au; Hope S Rugo; Laura J Esserman; E Shelley Hwang; Lisa M Coussens
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-08       Impact factor: 11.205

8.  Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.

Authors:  Elham Azizi; Ambrose J Carr; George Plitas; Andrew E Cornish; Catherine Konopacki; Sandhya Prabhakaran; Juozas Nainys; Kenmin Wu; Vaidotas Kiseliovas; Manu Setty; Kristy Choi; Rachel M Fromme; Phuong Dao; Peter T McKenney; Ruby C Wasti; Krishna Kadaveru; Linas Mazutis; Alexander Y Rudensky; Dana Pe'er
Journal:  Cell       Date:  2018-06-28       Impact factor: 41.582

9.  Tumor-infiltrating lymphocyte composition, organization and PD-1/ PD-L1 expression are linked in breast cancer.

Authors:  Laurence Buisseret; Soizic Garaud; Alexandre de Wind; Gert Van den Eynden; Anais Boisson; Cinzia Solinas; Chunyan Gu-Trantien; Céline Naveaux; Jean-Nicolas Lodewyckx; Hugues Duvillier; Ligia Craciun; Isabelle Veys; Denis Larsimont; Martine Piccart-Gebhart; John Stagg; Christos Sotiriou; Karen Willard-Gallo
Journal:  Oncoimmunology       Date:  2016-12-14       Impact factor: 8.110

10.  Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer.

Authors:  Zuzana Kos; Elvire Roblin; Rim S Kim; Stefan Michiels; Brandon D Gallas; Weijie Chen; Koen K van de Vijver; Shom Goel; Sylvia Adams; Sandra Demaria; Giuseppe Viale; Torsten O Nielsen; Sunil S Badve; W Fraser Symmans; Christos Sotiriou; David L Rimm; Stephen Hewitt; Carsten Denkert; Sibylle Loibl; Stephen J Luen; John M S Bartlett; Peter Savas; Giancarlo Pruneri; Deborah A Dillon; Maggie Chon U Cheang; Andrew Tutt; Jacqueline A Hall; Marleen Kok; Hugo M Horlings; Anant Madabhushi; Jeroen van der Laak; Francesco Ciompi; Anne-Vibeke Laenkholm; Enrique Bellolio; Tina Gruosso; Stephen B Fox; Juan Carlos Araya; Giuseppe Floris; Jan Hudeček; Leonie Voorwerk; Andrew H Beck; Jen Kerner; Denis Larsimont; Sabine Declercq; Gert Van den Eynden; Lajos Pusztai; Anna Ehinger; Wentao Yang; Khalid AbdulJabbar; Yinyin Yuan; Rajendra Singh; Crispin Hiley; Maise Al Bakir; Alexander J Lazar; Stephen Naber; Stephan Wienert; Miluska Castillo; Giuseppe Curigliano; Maria-Vittoria Dieci; Fabrice André; Charles Swanton; Jorge Reis-Filho; Joseph Sparano; Eva Balslev; I-Chun Chen; Elisabeth Ida Specht Stovgaard; Katherine Pogue-Geile; Kim R M Blenman; Frédérique Penault-Llorca; Stuart Schnitt; Sunil R Lakhani; Anne Vincent-Salomon; Federico Rojo; Jeremy P Braybrooke; Matthew G Hanna; M Teresa Soler-Monsó; Daniel Bethmann; Carlos A Castaneda; Karen Willard-Gallo; Ashish Sharma; Huang-Chun Lien; Susan Fineberg; Jeppe Thagaard; Laura Comerma; Paula Gonzalez-Ericsson; Edi Brogi; Sherene Loi; Joel Saltz; Frederick Klaushen; Lee Cooper; Mohamed Amgad; David A Moore; Roberto Salgado
Journal:  NPJ Breast Cancer       Date:  2020-05-12
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  3 in total

Review 1.  Incorporation of TILs in daily breast cancer care: how much evidence can we bear?

Authors:  Anne-Vibeke Laenkholm; Grace Callagy; Marcelo Balancin; John M S Bartlett; Christos Sotiriou; Caterina Marchio; Marleen Kok; Carlos Henrique Dos Anjos; Roberto Salgado
Journal:  Virchows Arch       Date:  2022-01-19       Impact factor: 4.535

2.  Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes.

Authors:  Nofar Erlichman; Tamir Baram; Tsipi Meshel; Dina Morein; Benny Da'adoosh; Adit Ben-Baruch
Journal:  Cancers (Basel)       Date:  2022-02-18       Impact factor: 6.575

3.  Clinicopathological characteristics and prognostic analysis of tumor-infiltrating lymphocytes (TILs) in ductal carcinoma in situ (DCIS) and DCIS with microinvasion (DCIS-Mi) of the breast.

Authors:  Huiqing Jia; Peng Zhao; Zhaoxu Chen; Guanqun Wang; Xianning Dong; Xiaoming Xing; Xiaohua Tan; Chengqin Wang
Journal:  Breast Cancer Res Treat       Date:  2022-03-08       Impact factor: 4.872
  3 in total

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