Jerome M Siegel1,2. 1. Neuropsychiatric Institute and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. 2. Neurobiology Research, Veterans Administration Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills, CA 91343, USA.
Abstract
PURPOSE OF REVIEW: I review the current status of the hypothesis that sleep is critically involved in memory consolidation and conclude that there are major methodological problems with the studies used to support this hypothesis. RECENT FINDINGS: Memory consolidation is similar in quiet waking and sleep (Humiston GB, Tucker MA, Summer T, Wamsley EJ. Sci Rep 18;9(1):19345, 2019), and suppression of REM sleep for long periods is compatible with learning and highly adaptive behavior (Lyamin OI, Korneva SM, Obukhova ED, Mukhametov LM, Siegel JM. Dokl Biol Sci 463:211-4, 2015; Lyamin OI, Kosenko PO, Korneva SM, Vyssotski AL, Mukhametov LM, Siegel JM. Current Biology 28(12):2000-5, 2018); despite their considerable abilities to navigate and remember, African elephants have very small amount of sleep, and learning interference effects have not been adequately controlled for in studies purporting to show sleep-dependent memory consolidation (Sosic-Vasic Z, Hille K, Kroner J, Spitzer M, Kornmeier J. Frontiers in psychology 9:82, 2018; Yonelinas AP, Ranganath C, Ekstrom AD, Wiltgen BJ. Nat Rev Neurosci 20(6):364-75, 2019). SUMMARY: Memory consolidation clearly occurs in both sleep and waking. Whether, and the extent to which, consolidation might differ in these two states has not been conclusively determined.
PURPOSE OF REVIEW: I review the current status of the hypothesis that sleep is critically involved in memory consolidation and conclude that there are major methodological problems with the studies used to support this hypothesis. RECENT FINDINGS: Memory consolidation is similar in quiet waking and sleep (Humiston GB, Tucker MA, Summer T, Wamsley EJ. Sci Rep 18;9(1):19345, 2019), and suppression of REM sleep for long periods is compatible with learning and highly adaptive behavior (Lyamin OI, Korneva SM, Obukhova ED, Mukhametov LM, Siegel JM. Dokl Biol Sci 463:211-4, 2015; Lyamin OI, Kosenko PO, Korneva SM, Vyssotski AL, Mukhametov LM, Siegel JM. Current Biology 28(12):2000-5, 2018); despite their considerable abilities to navigate and remember, African elephants have very small amount of sleep, and learning interference effects have not been adequately controlled for in studies purporting to show sleep-dependent memory consolidation (Sosic-Vasic Z, Hille K, Kroner J, Spitzer M, Kornmeier J. Frontiers in psychology 9:82, 2018; Yonelinas AP, Ranganath C, Ekstrom AD, Wiltgen BJ. Nat Rev Neurosci 20(6):364-75, 2019). SUMMARY: Memory consolidation clearly occurs in both sleep and waking. Whether, and the extent to which, consolidation might differ in these two states has not been conclusively determined.
Entities:
Keywords:
Consolidation; Learning; Memory; REM sleep; Sleep; Waking
Authors: Nadine Gravett; Adhil Bhagwandin; Robert Sutcliffe; Kelly Landen; Michael J Chase; Oleg I Lyamin; Jerome M Siegel; Paul R Manger Journal: PLoS One Date: 2017-03-01 Impact factor: 3.240
Authors: Rubén V Rial; Francesca Canellas; Mourad Akaârir; José A Rubiño; Pere Barceló; Aida Martín; Antoni Gamundí; M Cristina Nicolau Journal: Biology (Basel) Date: 2022-05-11