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Literature DB >> 34478502

Sexual Differentiation Specifies Cellular Responses to DNA Damage.

Abstract

Significant sex differences exist across cellular, tissue organization, and body system scales to serve the distinct sex-specific functions required for reproduction. They are present in all animals that reproduce sexually and have widespread impacts on normal development, aging, and disease. Observed from the moment of fertilization, sex differences are patterned by sexual differentiation, a lifelong process that involves mechanisms related to sex chromosome complement and the epigenetic and acute activational effects of sex hormones. In this mini-review, we examine evidence for sex differences in cellular responses to DNA damage, their underlying mechanisms, and how they might relate to sex differences in cancer incidence and response to DNA-damaging treatments.

Entities: Chemical

Keywords: DNA repair; radiation; senescence; sex differences; sexual differentiation

Mesh：

Substances：
Gonadal Steroid Hormones

Year: 2021 PMID： 34478502 PMCID： PMC8462381 DOI： 10.1210/endocr/bqab192

Source DB: PubMed Journal: Endocrinology ISSN： 0013-7227 Impact factor: 5.051

65 in total

1. Clinical Factors Associated with Urinary Tract Cancer in Individuals with Lynch Syndrome.

Authors: Jonathan W Wischhusen; Chinedu Ukaegbu; Tara G Dhingra; Hajime Uno; Fay Kastrinos; Sapna Syngal; Matthew B Yurgelun
Journal: Cancer Epidemiol Biomarkers Prev Date: 2019-10-15 Impact factor: 4.254

2. Sex determines the expression level of one third of the actively expressed genes in bovine blastocysts.

Authors: P Bermejo-Alvarez; D Rizos; D Rath; P Lonergan; A Gutierrez-Adan
Journal: Proc Natl Acad Sci U S A Date: 2010-02-04 Impact factor: 11.205

Review 3. Aging, cellular senescence, and cancer.

Authors: Judith Campisi
Journal: Annu Rev Physiol Date: 2012-11-08 Impact factor: 19.318

4. Differential expression of two genes located on the X chromosome between male and female in vitro-produced bovine embryos at the blastocyst stage.

Authors: A Gutiérrez-Adán; M Oter; B Martínez-Madrid; B Pintado; J De La Fuente
Journal: Mol Reprod Dev Date: 2000-02 Impact factor: 2.609

5. DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

Authors: Robert H te Poele; Andrei L Okorokov; Lesley Jardine; Jeffrey Cummings; Simon P Joel
Journal: Cancer Res Date: 2002-03-15 Impact factor: 12.701

Review 6. Revisiting tumor patterns and penetrance in germline TP53 mutation carriers: temporal phases of Li-Fraumeni syndrome.

Authors: Amina Amadou; Maria I W Achatz; Pierre Hainaut
Journal: Curr Opin Oncol Date: 2018-01 Impact factor: 3.645

2. All Damage Is Not Created Equal: Unraveling the Complexity of Sex Chromosomes and Hormones in the DNA Damage Response.

Authors: Monica Venere; Justin D Lathia
Journal: Endocrinology Date: 2021-12-01 Impact factor: 4.736

2 in total

Sexual Differentiation Specifies Cellular Responses to DNA Damage.

1. Clinical Factors Associated with Urinary Tract Cancer in Individuals with Lynch Syndrome.

2. Sex determines the expression level of one third of the actively expressed genes in bovine blastocysts.

Review 3. Aging, cellular senescence, and cancer.

4. Differential expression of two genes located on the X chromosome between male and female in vitro-produced bovine embryos at the blastocyst stage.

5. DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

Review 6. Revisiting tumor patterns and penetrance in germline TP53 mutation carriers: temporal phases of Li-Fraumeni syndrome.

7. Gender differences in chemical carcinogenesis in National Toxicology Program 2-year bioassays.

Review 8. Hallmarks of cancer: the next generation.

9. Analysis of cancer genomes reveals basic features of human aging and its role in cancer development.

10. Early X chromosome inactivation during human preimplantation development revealed by single-cell RNA-sequencing.

Review 1. The spectrum of sex differences in cancer.

2. All Damage Is Not Created Equal: Unraveling the Complexity of Sex Chromosomes and Hormones in the DNA Damage Response.