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Literature DB >> 35190302

The spectrum of sex differences in cancer.

Abstract

Sex differences in cellular and systems biology have been evolutionarily selected to optimize reproductive success in all species with little (sperm) and big (ova) gamete producers. They are evident from the time of fertilization and accrue throughout development through genetic, epigenetic, and circulating sex hormone-dependent mechanisms. Among other effects, they significantly impact on chromatin organization, metabolism, cell cycle regulation, immunity, longevity, and cancer risk and survival. Sex differences in cancer should be expected and accounted for in basic, translational, and clinical oncology research.

Entities: Chemical

Keywords: DNA repair; X chromosome; cancer; immunity; sex differences; tumor suppressor

Mesh：

Year: 2022 PMID： 35190302 PMCID： PMC8930612 DOI： 10.1016/j.trecan.2022.01.013

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

111 in total

1. X-chromosome-located microRNAs in immunity: might they explain male/female differences? The X chromosome-genomic context may affect X-located miRNAs and downstream signaling, thereby contributing to the enhanced immune response of females.

Authors: Iris Pinheiro; Lien Dejager; Claude Libert
Journal: Bioessays Date: 2011-09-28 Impact factor: 4.345

2. Type I IFN contributes to NK cell homeostasis, activation, and antitumor function.

Authors: Jeremy B Swann; Yoshihiro Hayakawa; Nadeen Zerafa; Kathleen C F Sheehan; Bernadette Scott; Robert D Schreiber; Paul Hertzog; Mark J Smyth
Journal: J Immunol Date: 2007-06-15 Impact factor: 5.422

3. Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women.

Authors: Morgane Griesbeck; Susanne Ziegler; Sophie Laffont; Nikaïa Smith; Lise Chauveau; Phillip Tomezsko; Armon Sharei; Georgio Kourjian; Filippos Porichis; Meghan Hart; Christine D Palmer; Michael Sirignano; Claudia Beisel; Heike Hildebrandt; Claire Cénac; Alexandra-Chloé Villani; Thomas J Diefenbach; Sylvie Le Gall; Olivier Schwartz; Jean-Philippe Herbeuval; Brigitte Autran; Jean-Charles Guéry; J Judy Chang; Marcus Altfeld
Journal: J Immunol Date: 2015-10-30 Impact factor: 5.422

4. Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolites.

Authors: Stephanie T Page; Stephen R Plymate; William J Bremner; Alvin M Matsumoto; David L Hess; Daniel W Lin; John K Amory; Peter S Nelson; Jennifer D Wu
Journal: Am J Physiol Endocrinol Metab Date: 2005-12-13 Impact factor: 4.310

5. Peripheral blood mitochondrial DNA copy number, length heteroplasmy and breast cancer risk: a replication study.

Authors: Jie Shen; Jie Wan; Renduo Song; Hua Zhao
Journal: Carcinogenesis Date: 2015-09-10 Impact factor: 4.944

6. Gender differences in chemical carcinogenesis in National Toxicology Program 2-year bioassays.

Authors: Sandeep Kadekar; Shyamal Peddada; Ilona Silins; John E French; Johan Högberg; Ulla Stenius
Journal: Toxicol Pathol Date: 2012-05-14 Impact factor: 1.902

7. Why does Jack, and not Jill, break his crown? Sex disparity in brain tumors.

Authors: Tao Sun; Nicole M Warrington; Joshua B Rubin
Journal: Biol Sex Differ Date: 2012-01-25 Impact factor: 5.027

8. Sex- and mutation-specific p53 gain-of-function activity in gliomagenesis.

Authors: Nathan C Rockwell; Wei Yang; Nicole M Warrington; Max V Staller; Malachi Griffith; Obi L Griffith; Christina A Gurnett; Barak A Cohen; Dustin Baldridge; Joshua B Rubin
Journal: Cancer Res Commun Date: 2021-12

Review 9. Assigning evidence to actionability: An introduction to variant interpretation in precision cancer medicine.

Authors: Peter Horak; Jonas Leichsenring; Hannah Goldschmid; Simon Kreutzfeldt; Daniel Kazdal; Veronica Teleanu; Volker Endris; Laura Gieldon; Michael Allgäuer; Anna-Lena Volckmar; Nicola Dikow; Marcus Renner; Martina Kirchner; Roland Penzel; Carolin Ploeger; Regine Brandt; Huriye Seker-Cin; Jan Budczies; Christoph E Heilig; Olaf Neumann; Christian P Schaaf; Peter Schirmacher; Stefan Fröhling; Albrecht Stenzinger
Journal: Genes Chromosomes Cancer Date: 2021-08-09 Impact factor: 5.006

Review 10. The X-files in immunity: sex-based differences predispose immune responses.

Authors: Eleanor N Fish
Journal: Nat Rev Immunol Date: 2008-09 Impact factor: 53.106

3 in total

1. Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array.

Authors: Olivia A Grant; Yucheng Wang; Meena Kumari; Nicolae Radu Zabet; Leonard Schalkwyk
Journal: Clin Epigenetics Date: 2022-05-14 Impact factor: 7.259

Review 2. High Risk-Human Papillomavirus in HNSCC: Present and Future Challenges for Epigenetic Therapies.

Authors: Lavinia Ghiani; Susanna Chiocca
Journal: Int J Mol Sci Date: 2022-03-23 Impact factor: 5.923

3. The immune microenvironment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma: a multiparametric quantitative and spatial analysis unveils a rationale to target treatment-naïve tumors with immune checkpoint inhibitors.

Authors: Anna Tosi; Beatrice Parisatto; Paolo Boscolo-Rizzo; Antonio Rosato; Anna Menegaldo; Giacomo Spinato; Maria Guido; Annarosa Del Mistro; Rossana Bussani; Fabrizio Zanconati; Margherita Tofanelli; Giancarlo Tirelli
Journal: J Exp Clin Cancer Res Date: 2022-09-20

3 in total