Literature DB >> 34470575

LC3A-mediated autophagy regulates lung cancer cell plasticity.

Chia-Cheng Miao1,2, Wen Hwang1,2, Ling-Yi Chu1, Li-Hao Yang1, Cam-Thu Ha1, Pei-Yu Chen1, Ming-Han Kuo1, Sheng-Chieh Lin1,3, Ya-Yu Yang4, Shuang-En Chuang4, Chia-Cherng Yu5, Shien-Tung Pan6, Mou-Chieh Kao7, Chuang-Rung Chang1, Yu-Ting Chou1.   

Abstract

ABBREVIATIONS: ATG14: autophagy related 14; CDH2: cadherin 2; ChIP-qPCR: chromatin immunoprecipitation quantitative polymerase chain reaction; CQ: chloroquine; ECAR: extracellular acidification rate; EMT: epithelial-mesenchymal transition; EPCAM: epithelial cell adhesion molecule; MAP1LC3A/LC3A: microtubule associated protein 1 light chain 3 alpha; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAP1LC3C/LC3C: microtubule associated protein 1 light chain 3 gamma; NDUFV2: NADH:ubiquinone oxidoreductase core subunit V2; OCR: oxygen consumption rate; ROS: reactive oxygen species; RT-qPCR: reverse-transcriptase quantitative polymerase chain reaction; SC: scrambled control; shRNA: short hairpin RNA; SNAI2: snail family transcriptional repressor 2; SOX2: SRY-box transcription factor 2; SQSTM1/p62: sequestosome 1; TGFB/TGF-β: transforming growth factor beta; TOMM20: translocase of outer mitochondrial membrane 20; ZEB1: zinc finger E-box binding homeobox 1.

Entities:  

Keywords:  Autophagy; LC3A; SOX2; cancer cell plasticity; lung cancer; mitochondria dynamics

Mesh：

Substances：

Year:  2021        PMID： 34470575      PMCID： PMC9037431          DOI： 10.1080/15548627.2021.1964224

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   13.391


  54 in total

1.  A critical role for autophagy in pancreatic cancer.

Authors:  Shenghong Yang; Alec C Kimmelman
Journal:  Autophagy       Date:  2011-08-01       Impact factor: 16.016

Review 2.  Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.

Authors:  Carl-Henrik Heldin; Maréne Landström; Aristidis Moustakas
Journal:  Curr Opin Cell Biol       Date:  2009-02-23       Impact factor: 8.382

Review 3.  Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

Authors:  Simran S Sabharwal; Paul T Schumacker
Journal:  Nat Rev Cancer       Date:  2014-11       Impact factor: 60.716

4.  Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.

Authors:  Jennifer A Kashatus; Aldo Nascimento; Lindsey J Myers; Annie Sher; Frances L Byrne; Kyle L Hoehn; Christopher M Counter; David F Kashatus
Journal:  Mol Cell       Date:  2015-02-05       Impact factor: 17.970

5.  Autophagy is required for glucose homeostasis and lung tumor maintenance.

Authors:  Gizem Karsli-Uzunbas; Jessie Yanxiang Guo; Sandy Price; Xin Teng; Saurabh V Laddha; Sinan Khor; Nada Y Kalaany; Tyler Jacks; Chang S Chan; Joshua D Rabinowitz; Eileen White
Journal:  Cancer Discov       Date:  2014-05-29       Impact factor: 39.397

6.  Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.

Authors:  Charles M Rudin; Steffen Durinck; Eric W Stawiski; John T Poirier; Zora Modrusan; David S Shames; Emily A Bergbower; Yinghui Guan; James Shin; Joseph Guillory; Celina Sanchez Rivers; Catherine K Foo; Deepali Bhatt; Jeremy Stinson; Florian Gnad; Peter M Haverty; Robert Gentleman; Subhra Chaudhuri; Vasantharajan Janakiraman; Bijay S Jaiswal; Chaitali Parikh; Wenlin Yuan; Zemin Zhang; Hartmut Koeppen; Thomas D Wu; Howard M Stern; Robert L Yauch; Kenneth E Huffman; Diego D Paskulin; Peter B Illei; Marileila Varella-Garcia; Adi F Gazdar; Frederic J de Sauvage; Richard Bourgon; John D Minna; Malcolm V Brock; Somasekar Seshagiri
Journal:  Nat Genet       Date:  2012-09-02       Impact factor: 38.330

7.  The emerging role of SOX2 in cell proliferation and survival and its crosstalk with oncogenic signaling in lung cancer.

Authors:  Yu-Ting Chou; Chih-Chan Lee; Shih-Hsin Hsiao; Sey-En Lin; Sheng-Chieh Lin; Chih-Hung Chung; Chi-Hsiu Chung; Yu-Rong Kao; Yuan-Hung Wang; Chien-Tsun Chen; Yau-Huei Wei; Cheng-Wen Wu
Journal:  Stem Cells       Date:  2013-12       Impact factor: 6.277

8.  Reactive oxygen species: role in the development of cancer and various chronic conditions.

Authors:  Gulam Waris; Haseeb Ahsan
Journal:  J Carcinog       Date:  2006-05-11

Review 9.  The Roles of Autophagy in Cancer.

Authors:  Chul Won Yun; Sang Hun Lee
Journal:  Int J Mol Sci       Date:  2018-11-05       Impact factor: 5.923

Review 10.  Mitophagy in Cancer: A Tale of Adaptation.

Authors:  Monica Vara-Perez; Blanca Felipe-Abrio; Patrizia Agostinis
Journal:  Cells       Date:  2019-05-22       Impact factor: 6.600
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  1 in total

1.  Ferroptosis-related gene signatures in neuroblastoma associated with prognosis.

Authors:  Yiru Chen; Zihao Li; Qingtai Cao; Haoyu Guan; Longfei Mao; Mingyi Zhao
Journal:  Front Cell Dev Biol       Date:  2022-09-06
  1 in total

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