Literature DB >> 19237272

Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.

Carl-Henrik Heldin1, Maréne Landström, Aristidis Moustakas.   

Abstract

Members of the transforming growth factor-beta (TGF-beta) family have important roles during embryogenesis, as well as in the control of tissue homeostasis in the adult. They exert their cellular effects via binding to serine/threonine kinase receptors. Members of the Smad family of transcription factors are important intracellular messengers, and recent studies have shown that the ubiquitin ligase TRAF6 mediates other specific signals. TGF-beta signaling is tightly controlled by post-translational modifications, which regulate the activity, stability, and subcellular localization of the signaling components. The aim of this review is to summarize some of the recent findings on the mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.

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Year:  2009        PMID： 19237272     DOI： 10.1016/j.ceb.2009.01.021

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  283 in total

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Authors:  Fangyan Dai; Tao Shen; Zhaoyong Li; Xia Lin; Xin-Hua Feng
Journal:  EMBO Rep       Date:  2011-10-28       Impact factor: 8.807

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Journal:  J Biol Chem       Date:  2012-06-15       Impact factor: 5.157

6.  Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.

Authors:  Yuto Kamiya; Kohei Miyazono; Keiji Miyazawa
Journal:  J Biol Chem       Date:  2010-07-27       Impact factor: 5.157

Review 7.  Immunological Consequences of Epithelial-Mesenchymal Transition in Tumor Progression.

Authors:  Peter J Chockley; Venkateshwar G Keshamouni
Journal:  J Immunol       Date:  2016-08-01       Impact factor: 5.422

8.  Loss of ACVRIB leads to increased squamous cell carcinoma aggressiveness through alterations in cell-cell and cell-matrix adhesion proteins.

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Journal:  Am J Cancer Res       Date:  2017-12-01       Impact factor: 6.166

Review 9.  Transforming growth factor beta (TGF-beta) and inflammation in cancer.

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Journal:  Cytokine Growth Factor Rev       Date:  2009-12-16       Impact factor: 7.638

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Authors:  Wei-Lei Yang; Ching-Yuan Wu; Juan Wu; Hui-Kuan Lin
Journal:  Cell Cycle       Date:  2010-02-01       Impact factor: 4.534
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