Literature DB >> 34462587

Compact RNA editors with small Cas13 proteins.

Soumya Kannan1,2,3,4,5, Han Altae-Tran1,2,3,4,5, Xin Jin1,2,3,4,5,6,7, Victoria J Madigan1,2,3,4,5, Rachel Oshiro1,2,3,4,5, Kira S Makarova8, Eugene V Koonin8, Feng Zhang9,10,11,12,13.   

Abstract

CRISPR-Cas13 systems have been developed for precise RNA editing, and can potentially be used therapeutically when temporary changes are desirable or when DNA editing is challenging. We have identified and characterized an ultrasmall family of Cas13b proteins-Cas13bt-that can mediate mammalian transcript knockdown. We have engineered compact variants of REPAIR and RESCUE RNA editors by functionalizing Cas13bt with adenosine and cytosine deaminase domains, and demonstrated packaging of the editors within a single adeno-associated virus.
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Year:  2021        PMID： 34462587      PMCID： PMC8929162          DOI： 10.1038/s41587-021-01030-2

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   68.164


  34 in total

1.  Quantitative analysis of the packaging capacity of recombinant adeno-associated virus.

Authors:  J Y Dong; P D Fan; R A Frizzell
Journal:  Hum Gene Ther       Date:  1996-11-10       Impact factor: 5.695

2.  FastTree 2--approximately maximum-likelihood trees for large alignments.

Authors:  Morgan N Price; Paramvir S Dehal; Adam P Arkin
Journal:  PLoS One       Date:  2010-03-10       Impact factor: 3.240

3.  Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28.

Authors:  Aaron A Smargon; David B T Cox; Neena K Pyzocha; Kaijie Zheng; Ian M Slaymaker; Jonathan S Gootenberg; Omar A Abudayyeh; Patrick Essletzbichler; Sergey Shmakov; Kira S Makarova; Eugene V Koonin; Feng Zhang
Journal:  Mol Cell       Date:  2017-01-05       Impact factor: 17.970

4.  A cytosine deaminase for programmable single-base RNA editing.

Authors:  Omar O Abudayyeh; Jonathan S Gootenberg; Brian Franklin; Jeremy Koob; Max J Kellner; Alim Ladha; Julia Joung; Paul Kirchgatterer; David B T Cox; Feng Zhang
Journal:  Science       Date:  2019-07-11       Impact factor: 47.728

5.  The IMG/M data management and analysis system v.6.0: new tools and advanced capabilities.

Authors:  I-Min A Chen; Ken Chu; Krishnaveni Palaniappan; Anna Ratner; Jinghua Huang; Marcel Huntemann; Patrick Hajek; Stephan Ritter; Neha Varghese; Rekha Seshadri; Simon Roux; Tanja Woyke; Emiley A Eloe-Fadrosh; Natalia N Ivanova; Nikos C Kyrpides
Journal:  Nucleic Acids Res       Date:  2021-01-08       Impact factor: 16.971

6.  MG-RAST, a Metagenomics Service for Analysis of Microbial Community Structure and Function.

Authors:  Kevin P Keegan; Elizabeth M Glass; Folker Meyer
Journal:  Methods Mol Biol       Date:  2016

7.  Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury.

Authors:  Udayan Apte; Sucha Singh; Gang Zeng; Benjamin Cieply; Mohamed A Virji; Tong Wu; Satdarshan P S Monga
Journal:  Am J Pathol       Date:  2009-08-13       Impact factor: 4.307

Review 8.  CRISPR-Based Technologies: Impact of RNA-Targeting Systems.

Authors:  Michael P Terns
Journal:  Mol Cell       Date:  2018-11-01       Impact factor: 17.970

9.  The genome portal of the Department of Energy Joint Genome Institute: 2014 updates.

Authors:  Henrik Nordberg; Michael Cantor; Serge Dusheyko; Susan Hua; Alexander Poliakov; Igor Shabalov; Tatyana Smirnova; Igor V Grigoriev; Inna Dubchak
Journal:  Nucleic Acids Res       Date:  2013-11-12       Impact factor: 16.971

Review 10.  Adeno-Associated Virus Gene Therapy for Liver Disease.

Authors:  Lisa M Kattenhorn; Christopher H Tipper; Lorelei Stoica; Deborah S Geraghty; Teresa L Wright; K Reed Clark; Samuel C Wadsworth
Journal:  Hum Gene Ther       Date:  2016-12       Impact factor: 5.695
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  20 in total

Review 1.  Screening circular RNAs with functional potential using the RfxCas13d/BSJ-gRNA system.

Authors:  Siqi Li; Hao Wu; Ling-Ling Chen
Journal:  Nat Protoc       Date:  2022-07-13       Impact factor: 17.021

2.  Optimization of specific RNA knockdown in mammalian cells with CRISPR-Cas13.

Authors:  Brandon Joseph Davis Burris; Adrian Moises Molina Vargas; Brandon J Park; Mitchell R O'Connell
Journal:  Methods       Date:  2022-08-17       Impact factor: 4.647

3.  Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro.

Authors:  Leiping Zeng; Yanxia Liu; Xammy Huu Nguyenla; Timothy R Abbott; Mengting Han; Yanyu Zhu; Augustine Chemparathy; Xueqiu Lin; Xinyi Chen; Haifeng Wang; Draven A Rane; Jordan M Spatz; Saket Jain; Arjun Rustagi; Benjamin Pinsky; Adrianna E Zepeda; Anastasia P Kadina; John A Walker; Kevin Holden; Nigel Temperton; Jennifer R Cochran; Annelise E Barron; Michael D Connolly; Catherine A Blish; David B Lewis; Sarah A Stanley; Marie F La Russa; Lei S Qi
Journal:  Nat Commun       Date:  2022-05-19       Impact factor: 17.694

Review 4.  Cas-Based Systems for RNA Editing in Gene Therapy of Monogenic Diseases: In Vitro and in Vivo Application and Translational Potential.

Authors:  Vasiliy V Reshetnikov; Angelina V Chirinskaite; Julia V Sopova; Roman A Ivanov; Elena I Leonova
Journal:  Front Cell Dev Biol       Date:  2022-06-16

Review 5.  The use of new CRISPR tools in cardiovascular research and medicine.

Authors:  Masataka Nishiga; Chun Liu; Lei S Qi; Joseph C Wu
Journal:  Nat Rev Cardiol       Date:  2022-02-10       Impact factor: 49.421

6.  Structure and engineering of the minimal type VI CRISPR-Cas13bt3.

Authors:  Ryoya Nakagawa; Soumya Kannan; Han Altae-Tran; Satoru N Takeda; Atsuhiro Tomita; Hisato Hirano; Tsukasa Kusakizako; Tomohiro Nishizawa; Keitaro Yamashita; Feng Zhang; Hiroshi Nishimasu; Osamu Nureki
Journal:  Mol Cell       Date:  2022-08-25       Impact factor: 19.328

7.  CRISPR systems go mini.

Authors:  Linda Koch
Journal:  Nat Rev Genet       Date:  2021-11       Impact factor: 53.242

Review 8.  Drug delivery systems for RNA therapeutics.

Authors:  Kalina Paunovska; David Loughrey; James E Dahlman
Journal:  Nat Rev Genet       Date:  2022-01-04       Impact factor: 59.581

Review 9.  How to Find the Right RNA-Sensing CRISPR-Cas System for an In Vitro Application.

Authors:  Escarlet Díaz-Galicia; Raik Grünberg; Stefan T Arold
Journal:  Biosensors (Basel)       Date:  2022-01-19

Review 10.  Long RNA-Mediated Chromatin Regulation in Fission Yeast and Mammals.

Authors:  Matthew W Faber; Tommy V Vo
Journal:  Int J Mol Sci       Date:  2022-01-16       Impact factor: 5.923
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