| Literature DB >> 30388409 |
Abstract
DNA-targeting CRISPR-Cas systems, such as those employing the RNA-guided Cas9 or Cas12 endonucleases, have revolutionized our ability to predictably edit genomes and control gene expression. Here, I summarize information on RNA-targeting CRISPR-Cas systems and describe recent advances in converting them into powerful and programmable RNA-binding and cleavage tools with a wide range of novel and important biotechnological and biomedical applications.Entities:
Keywords: CRISPR; Cas10; Cas13; Cas9; RNA editing; RNA targeting; Type III CRISPR-Cas systems; Type VI CRISPR-Cas systems; gene editing
Mesh:
Substances:
Year: 2018 PMID: 30388409 PMCID: PMC6239212 DOI: 10.1016/j.molcel.2018.09.018
Source DB: PubMed Journal: Mol Cell ISSN: 1097-2765 Impact factor: 17.970