| Literature DB >> 34446331 |
Leela Goel1, Huaiyu Wu2, Bohua Zhang2, Jinwook Kim3, Paul A Dayton3, Zhen Xu4, Xiaoning Jiang5.
Abstract
Recent in vitro work has revealed that a forward-viewing intravascular (FVI) transducer has sonothrombolysis applications. However, the safety of this device has yet to be evaluated. In this study, we evaluated the safety of this device in terms of tissue heating, vessel damage and particle debris size during sonothrombolysis using microbubbles or nanodroplets with tissue plasminogen activator, in both retracted and unretracted blood clots. The in vitro and ex vivo sonothrombolysis tests using FVI transducers revealed a temperature rise of less than 1°C, no vessel damage as assessed by histology and no downstream clot particles >500 µm. These in vitro and ex vivo results indicate that the FVI transducer poses minimal risk for sonothrombolysis applications and should be further evaluated in animal models.Entities:
Keywords: Intravascular sonothrombolysis; Microbubbles; Nanodroplets; Retracted clots; Safety; Tissue plasminogen activator; Ultrasound-assisted thrombolysis
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Year: 2021 PMID： 34446331 PMCID： PMC8487993 DOI： 10.1016/j.ultrasmedbio.2021.07.018
Source DB: PubMed Journal: Ultrasound Med Biol ISSN： 0301-5629 Impact factor: 2.998