Literature DB >> 34436714

Cost and Cost-Effectiveness of Incentives for Viral Suppression in People Living with HIV.

Laura J Dunlap1, Stephen Orme2,3, Gary A Zarkin1, David R Holtgrave4, Catherine Maulsby5, Andrew M Rodewald6, August F Holtyn6, Kenneth Silverman6.   

Abstract

Only 63% of people living with HIV in the United States are achieving viral suppression. Structural and social barriers limit adherence to antiretroviral therapy which furthers the HIV epidemic while increasing health care costs. This study calculated the cost and cost-effectiveness of a contingency management intervention with cash incentives. People with HIV and detectable viral loads were randomized to usual care or an incentive group. Individuals could earn up to $3650 per year if they achieved and maintained an undetectable viral load. The average 1-year intervention cost, including incentives, was $4105 per patient. The average health care costs were $27,189 per patient in usual care and $35,853 per patient in the incentive group. We estimated a cost of $28,888 per quality-adjusted life-year (QALY) gained, which is well below accepted cost-per-QALY thresholds. Contingency management with cash incentives is a cost-effective intervention for significantly increasing viral suppression.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Antiretroviral medication adherence; Cost-effectiveness; HIV; Incentives; QALYs

Mesh:

Year:  2021        PMID: 34436714     DOI: 10.1007/s10461-021-03439-x

Source DB:  PubMed          Journal:  AIDS Behav        ISSN: 1090-7165


  25 in total

Review 1.  Cost-effectiveness of adherence-enhancing interventions: a systematic review.

Authors:  Tzahit Simon-Tuval; Peter J Neumann; Dan Greenberg
Journal:  Expert Rev Pharmacoecon Outcomes Res       Date:  2016-02-03       Impact factor: 2.217

Review 2.  Cost-effectiveness of adherence interventions for highly active antiretroviral therapy: a systematic review.

Authors:  Tim Mathes; Dawid Pieper; Sunya-Lee Antoine; Michaela Eikermann
Journal:  Int J Technol Assess Health Care       Date:  2013-06-12       Impact factor: 2.188

3.  Effect of Patient Navigation With or Without Financial Incentives on Viral Suppression Among Hospitalized Patients With HIV Infection and Substance Use: A Randomized Clinical Trial.

Authors:  Lisa R Metsch; Daniel J Feaster; Lauren Gooden; Tim Matheson; Maxine Stitzer; Moupali Das; Mamta K Jain; Allan E Rodriguez; Wendy S Armstrong; Gregory M Lucas; Ank E Nijhawan; Mari-Lynn Drainoni; Patricia Herrera; Pamela Vergara-Rodriguez; Jeffrey M Jacobson; Michael J Mugavero; Meg Sullivan; Eric S Daar; Deborah K McMahon; David C Ferris; Robert Lindblad; Paul VanVeldhuisen; Neal Oden; Pedro C Castellón; Susan Tross; Louise F Haynes; Antoine Douaihy; James L Sorensen; David S Metzger; Raul N Mandler; Grant N Colfax; Carlos del Rio
Journal:  JAMA       Date:  2016-07-12       Impact factor: 56.272

4.  The cost effectiveness of combination antiretroviral therapy for HIV disease.

Authors:  K A Freedberg; E Losina; M C Weinstein; A D Paltiel; C J Cohen; G R Seage; D E Craven; H Zhang; A D Kimmel; S J Goldie
Journal:  N Engl J Med       Date:  2001-03-15       Impact factor: 91.245

5.  Updating cost-effectiveness--the curious resilience of the $50,000-per-QALY threshold.

Authors:  Peter J Neumann; Joshua T Cohen; Milton C Weinstein
Journal:  N Engl J Med       Date:  2014-08-28       Impact factor: 91.245

6.  Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infection.

Authors:  Sue J Goldie; A David Paltiel; Milton C Weinstein; Elena Losina; George R Seage; April D Kimmel; Rochelle P Walensky; Paul E Sax; Kenneth A Freedberg
Journal:  Am J Med       Date:  2003-12-01       Impact factor: 4.965

7.  The cost-effectiveness of counseling strategies to improve adherence to highly active antiretroviral therapy among men who have sex with men.

Authors:  Gregory S Zaric; Ahmed M Bayoumi; Margaret L Brandeau; Douglas K Owens
Journal:  Med Decis Making       Date:  2008-03-18       Impact factor: 2.583

Review 8.  On what basis are medical cost-effectiveness thresholds set? Clashing opinions and an absence of data: a systematic review.

Authors:  David Cameron; Jasper Ubels; Fredrik Norström
Journal:  Glob Health Action       Date:  2018       Impact factor: 2.640

9.  Financial Incentives for Linkage to Care and Viral Suppression Among HIV-Positive Patients: A Randomized Clinical Trial (HPTN 065).

Authors:  Wafaa M El-Sadr; Deborah Donnell; Geetha Beauchamp; H Irene Hall; Lucia V Torian; Barry Zingman; Garret Lum; Michael Kharfen; Richard Elion; Jason Leider; Fred M Gordin; Vanessa Elharrar; David Burns; Allison Zerbe; Theresa Gamble; Bernard Branson
Journal:  JAMA Intern Med       Date:  2017-08-01       Impact factor: 21.873

10.  Adherence to antiretroviral therapy among HIV/ AIDS patients in the context of early treatment initiation in Vietnam.

Authors:  Hue Thi Mai; Giang Minh Le; Bach Xuan Tran; Ha Ngoc Do; Carl A Latkin; Luong Thanh Nguyen; Thao Phuong Thi Thai; Huong Thi Le; Anh Toan Ngo; Cuong Tat Nguyen; Cyrus Sh Ho; Roger Cm Ho
Journal:  Patient Prefer Adherence       Date:  2018-10-11       Impact factor: 2.711

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