Jorge Velazquez-Roman1, Uriel A Angulo-Zamudio1, Nidia León-Sicairos2, Julio Medina-Serrano3, Nora DeLira-Bustillos4, Hugo Villamil-Ramírez5, Samuel Canizales-Quinteros5, Luis Macías-Kauffer5, Abraham Campos-Romero6, Jonathan Alcántar-Fernández6, Adrian Canizalez-Roman7. 1. School of Medicine, CIASaP, Autonomous University of Sinaloa, 80246 Culiacan, Sinaloa, Mexico. 2. School of Medicine, CIASaP, Autonomous University of Sinaloa, 80246 Culiacan, Sinaloa, Mexico; Pediatric Hospital of Sinaloa, 80200 Culiacan, Sinaloa, Mexico. 3. Programa de Maestría en Ciencias en Biomedicina Molecular, UAS, 80246 Culiacan, Sinaloa, Mexico; Coordinación de Planeación y Enlace Institucional, Órgano de Operación Administrativa Desconcentrada (OOAD) de Sinaloa, Instituto Mexicano del Seguro Social (IMSS), Culiacan Sinaloa, Mexico. 4. Programa de Maestría en Ciencias en Biomedicina Molecular, UAS, 80246 Culiacan, Sinaloa, Mexico. 5. Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/INMEGEN, Mexico City, Mexico. 6. Salud Digna A.C., 80000 Culiacán, Sinaloa, Mexico. 7. School of Medicine, CIASaP, Autonomous University of Sinaloa, 80246 Culiacan, Sinaloa, Mexico; The Women's Hospital, Secretariat of Health, 80020 Culiacan, Sinaloa, Mexico. Electronic address: canizalez@uas.edu.mx.
Abstract
AIM: To identify associations among allelic variants of the genes FTO, ABCA1, ADRB3, and PPARG with anthropometric and biochemical traits, metabolic diseases (obesity, T2D or metabolic syndrome) in an adult population from Northwest Mexico. METHODS: Blood samples were collected from 846 subjects including 266 normal weight subjects, 285 with obesity, and 295 with T2D. Of the 846 persons in the study, 365 presented metabolic syndrome diagnostic criteria. Anthropometric and biochemical traits were recorded and 4 single nucleotide polymorphisms (SNPs): FTO rs9939609 A-allele, ABCA1 rs9282541 A-allele, ADRB3 rs4994 G-allele, and PPARG rs1801282 G-allele were genotyped by real-time PCR. RESULTS: FTO rs9939609 A-allele was significantly associated with obesity (p: 8.3 × 10-4), and metabolic syndrome (p: 0.001), but no individual SNPs were significantly associated with T2D. Finally, the cumulative risk of the four SNPs was significantly associated with obesity (p: 1.95 × 10-4). CONCLUSION: Associations in FTO, ABCA, ADRB3, and PPARG SNPs presented in this study with obesity and metabolic syndrome could represent a risk for developing metabolic diseases in Northwest Mexican adult subjects.
AIM: To identify associations among allelic variants of the genes FTO, ABCA1, ADRB3, and PPARG with anthropometric and biochemical traits, metabolic diseases (obesity, T2D or metabolic syndrome) in an adult population from Northwest Mexico. METHODS: Blood samples were collected from 846 subjects including 266 normal weight subjects, 285 with obesity, and 295 with T2D. Of the 846 persons in the study, 365 presented metabolic syndrome diagnostic criteria. Anthropometric and biochemical traits were recorded and 4 single nucleotide polymorphisms (SNPs): FTO rs9939609 A-allele, ABCA1 rs9282541 A-allele, ADRB3 rs4994 G-allele, and PPARG rs1801282 G-allele were genotyped by real-time PCR. RESULTS: FTO rs9939609 A-allele was significantly associated with obesity (p: 8.3 × 10-4), and metabolic syndrome (p: 0.001), but no individual SNPs were significantly associated with T2D. Finally, the cumulative risk of the four SNPs was significantly associated with obesity (p: 1.95 × 10-4). CONCLUSION: Associations in FTO, ABCA, ADRB3, and PPARG SNPs presented in this study with obesity and metabolic syndrome could represent a risk for developing metabolic diseases in Northwest Mexican adult subjects.