Cheng Hean Lo1, Jason N Brown2, Eric J G Dantzer3, Peter K M Maitz4, John G Vandervord5, Marcus J D Wagstaff6, Timothy M Barker7, Heather Cleland8. 1. Victorian Adult Burns Service, The Alfred, 55 Commercial Rd, Melbourne, VIC 3004, Australia; Department of Surgery, Central Clinical School, Monash University, 99 Commercial Rd, Melbourne, VIC 3004, Australia. Electronic address: c.lo@alfred.org.au. 2. Professor Stuart Pegg Adult Burns Centre, Royal Brisbane and Women's Hospital, Butterfield St, Herston, QLD 4029, Australia. Electronic address: Jason.brown@health.qld.gov.au. 3. Centre des Brûlés, Hôpital d'Instruction des Armées Sainte-Anne, 2 Boulevard Sainte-Anne, 83000, Toulon, France. Electronic address: eric.dantzer@wanadoo.fr. 4. Burns Unit, Concord Repatriation General Hospital, Hospital Road, Concord, NSW 2139, Australia. Electronic address: peter.maitz@sydney.edu.au. 5. Department of Burns, Reconstructive and Plastic Surgery, Royal North Shore Hospital, Reserve Road, St. Leonards, NSW 2065, Australia. Electronic address: johnvandervord@bigpond.com. 6. Adult Burns Service and Department of Plastic and Reconstructive Surgery, Royal Adelaide Hospital, Port Rd, Adelaide, SA 5000, Australia. Electronic address: m.wagstaff@doctors.org.uk. 7. PolyNovo Biomaterials Pty Ltd., 2/320 Lorimer Street, Port Melbourne, VIC 3207, Australia. Electronic address: tim.b@polynovo.com. 8. Victorian Adult Burns Service, The Alfred, 55 Commercial Rd, Melbourne, VIC 3004, Australia; Department of Surgery, Central Clinical School, Monash University, 99 Commercial Rd, Melbourne, VIC 3004, Australia. Electronic address: h.cleland@alfred.org.au.
Abstract
INTRODUCTION: For extensive burns, autologous donor skin may be insufficient for early debridement and grafting in a single stage. A novel, synthetic polyurethane dermal template (NovoSorb® Biodegradable Temporising Matrix, BTM) was developed to address this need. The aim of this study was to evaluate use of BTM for primary dermal repair after deep burn injury. METHODS: A multicentre, prospective, clinical study was conducted from September 2015 to May 2018. The primary endpoint was % split skin graft take over applied BTM at 7-10 days after grafting. Secondary endpoints included % BTM take, incidence of infection and adverse events, and scar quality to 12 months after BTM application. RESULTS: Thirty patients were treated with BTM and delayed split skin grafting. The % graft take had a mean of 81.9% and % BTM take had a mean of 88.6%, demonstrating effective integration of BTM. When managed appropriately, it was possible for BTM to integrate successfully despite findings suggestive of infection. Scar quality improved over time. DISCUSSION: These results provide additional clinical evidence on the safety and performance of BTM as an effective dermal substitute in the treatment of patients with deep burn injuries.
INTRODUCTION: For extensive burns, autologous donor skin may be insufficient for early debridement and grafting in a single stage. A novel, synthetic polyurethane dermal template (NovoSorb® Biodegradable Temporising Matrix, BTM) was developed to address this need. The aim of this study was to evaluate use of BTM for primary dermal repair after deep burn injury. METHODS: A multicentre, prospective, clinical study was conducted from September 2015 to May 2018. The primary endpoint was % split skin graft take over applied BTM at 7-10 days after grafting. Secondary endpoints included % BTM take, incidence of infection and adverse events, and scar quality to 12 months after BTM application. RESULTS: Thirty patients were treated with BTM and delayed split skin grafting. The % graft take had a mean of 81.9% and % BTM take had a mean of 88.6%, demonstrating effective integration of BTM. When managed appropriately, it was possible for BTM to integrate successfully despite findings suggestive of infection. Scar quality improved over time. DISCUSSION: These results provide additional clinical evidence on the safety and performance of BTM as an effective dermal substitute in the treatment of patients with deep burn injuries.
Authors: Alen Palackic; Robert P Duggan; Matthew S Campbell; Elliot Walters; Ludwik K Branski; Amina El Ayadi; Steven E Wolf Journal: Semin Plast Surg Date: 2022-04-12 Impact factor: 2.195